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CAS No.: | 1263-89-4 |
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Name: | PAROMOMYCIN SULFATE |
Molecular Structure: | |
Formula: | C23H45N5O14•H2O4S |
Molecular Weight: | 713.81 |
Synonyms: | Aminosidine Sulphate;Paromomycin sulfate salt;Humatin (TN);Paromomycin sulfate (JAN/USP);Prestwick_1023;D-Streptamine,O-2-amino-2-deoxy-R-Dglucopyranosyl-( 1f4)-O-[O-2,6-diamino-2,- 6-dideoxy-a-L-idopyranosyl-(1f3)-a-Dribofuranosyl-( 1f5)]-2-deoxy-,sulfate (salt);Paromomycin sulfate;Gabbroral;Humatin;5-amino-6-[4,6-diamino-2-[(3S,4S,5R)-4-[3-amino-6-(aminomethyl)-4,5-dihydroxy-oxan-2-yl]oxy-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-3-hydroxy-cyclohexyl]oxy-2-(hydroxymethyl)oxane-3,4-diol; sulfuric acid;(2R,3S,4R,5R,6S)-5-amino-6-[(1R,2S,3S,4R,6S)-4,6-diamino-2-[(2S,3R,4R,5R)-4-[(2R,3R,4R,5R,6S)-3-amino-6-(aminomethyl)-4,5-dihydroxy-oxan-2-yl]oxy-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-3-hydroxy-cyclohexyl]oxy-2-(hydroxymethyl)oxane-3,4-diol; sulfuric acid; |
EINECS: | 215-031-7 |
Melting Point: | >200oC |
Boiling Point: | 939.8 °C at 760 mmHg |
Flash Point: | 522.2 °C |
Solubility: | water: 50 mg/mL |
Appearance: | powder |
Hazard Symbols: | Xi |
Risk Codes: | 23/24/25-61-36/37/38 |
Safety: | 26-36/37-45-38-36 |
PSA: | 430.30000 |
LogP: | -4.93220 |
This chemical is called Paromomycin sulphates, and it's also named as D-Streptamine, O-2-amino-2-deoxy-alpha-D-glucopyranosyl-(1-4)-O-(O-2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl-(1-3)-beta-D-ribofuranosyl-(1-5))-2-deoxy-, sulfate (salt). With the classification codes Anthelmintic; Anti-amebic; Drug / Therapeutic Agent; Mutation data, its product categories are Antibiotics A to; A ntibiotics by Application; Chemical Structure Class; Genetic Marker Selection Antibiotics; Interferes with Protein Synthesis Spectrum of Activity; Mechanism of Action. The CAS registry number of this chemical is 1263-89-4. Additionally, it should be stored at 0-6°C where the room is dry and ventilated. Keep the Paromomycin sulphates away from the oxidants.
Other characteristics of the Paromomycin sulphates can be summarised as followings: (1)ACD/LogP: -3.27; (2)# of Rule of 5 Violations: 3; (3)ACD/LogD (pH 5.5): -10.06; (4)ACD/LogD (pH 7.4): -8.33; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 1; (8)ACD/KOC (pH 7.4): 1; (9)#H bond acceptors: 19; (10)#H bond donors: 18; (11)#Freely Rotating Bonds: 22; (12)Polar Surface Area: 145.42 Å2; (13)Flash Point: 522.2 °C; (14)Enthalpy of Vaporization: 155.13 kJ/mol; (15)Boiling Point: 939.8 °C at 760 mmHg; (16)Vapour Pressure: 0 mmHg at 25°C.
Uses of this chemical: The Paromomycin sulphates is an oligosaccharide antibiotic produced by various streptomyces. It's aminoglycoside antibiotics. Generally, this chemical is used on the treatment of bacillary dysentery and other gastrointestinal infections. It can also cure amoebic dysentery. Moreover, you can find that it used on fire extinguishing agents, dry powder, foam, sand, carbon dioxide and water spray.
When you are using this chemical, please be cautious about it as the following: This chemical is irritating to eyes, respiratory system and skin. It may cause harm to the unborn child. You should wear suitable protective clothing if you use it. In case of contacting with eyes, rinse immediately with plenty of water and seek medical advice.
You can still convert the following datas into molecular structure:
1.InChI: InChI=1/C23H45N5O14.H2O4S/c24-2-7-13(32)15(34)10(27)21(37-7)41-19-9(4-30)39-23(17(19)36)42-20-12(31)5(25)1-6(26)18(20)40-22-11(28)16(35)14(33)8(3-29)38-22;1-5(2,3)4/h5-23,29-36H,1-4,24-28H2;(H2,1,2,3,4)/t5-,6+,7+,8-,9-,10-,11-,12+,13-,14-,15-,16-,17-,18?,19-,20-,21-,22-,23?;/m1./s1
2.Smiles:O1[C@H](O[C@H]2[C@@H](O)[C@@H](O[C@H]3[C@@H](O[C@@H]4[C@H](N)[C@H]([C@@H]([C@H](O4)CO)O)O)[C@@H](N)C[C@H](N)[C@@H]3O)O[C@@H]2CO)[C@H](N)[C@@H](O)[C@@H]([C@@H]1CN)O.OS(=O)(O)=O
The toxicity data is as follows:
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
guinea pig | LD50 | subcutaneous | 1700mg/kg (1700mg/kg) | Chemotherapy Vol. 16, Pg. 105, 1968. | |
monkey | LDLo | intravenous | 93mg/kg (93mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Antibiotics and Chemotherapy Vol. 9, Pg. 730, 1959. |
mouse | LD50 | intracrebral | 22300ug/kg (22.3mg/kg) | SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) SKIN AND APPENDAGES (SKIN): HAIR: OTHER | Chemotherapy Vol. 16, Pg. 114, 1968. |
mouse | LD50 | intramuscular | 438mg/kg (438mg/kg) | Japanese Journal of Antibiotics. Vol. 36, Pg. 644, 1983. | |
mouse | LD50 | intraperitoneal | 750mg/kg (750mg/kg) | SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD SKIN AND APPENDAGES (SKIN): HAIR: OTHER | Chemotherapy Vol. 16, Pg. 114, 1968. |
mouse | LD50 | intravenous | 90mg/kg (90mg/kg) | Therapie. Vol. 16, Pg. 184, 1961. | |
mouse | LD50 | oral | 23500mg/kg (23500mg/kg) | Japanese Journal of Antibiotics. Vol. 36, Pg. 644, 1983. | |
mouse | LD50 | subcutaneous | 123mg/kg (123mg/kg) | Therapie. Vol. 16, Pg. 184, 1961. | |
rat | LD50 | intramuscular | 1200mg/kg (1200mg/kg) | Drugs in Japan Vol. 6, Pg. 595, 1982. | |
rat | LD50 | intravenous | 181mg/kg (181mg/kg) | Antibiotics and Chemotherapy Vol. 9, Pg. 730, 1959. | |
rat | LD50 | oral | 21620mg/kg (21620mg/kg) | Drugs in Japan Vol. 6, Pg. 595, 1982. | |
rat | LD50 | subcutaneous | 870mg/kg (870mg/kg) | PERIPHERAL NERVE AND SENSATION: SENSORY CHANGE INVOLVING PERIPHERAL NERVE SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE | Chemotherapy Vol. 16, Pg. 114, 1968. |