CAS No.127-48-0,3,5,5-TRIMETHYLOXAZOLIDINE-2,4-DIONE Suppliers

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Basic Information

Molecular Structure:
CAS No.:	127-48-0
Name:	3,5,5-TRIMETHYLOXAZOLIDINE-2,4-DIONE
Article Data:	14

Formula:	C6H9 N O3
Molecular Weight:	143.142
Synonyms:	3,3,5-Trimethyl-2,4-diketooxazolidine;3,5,5-Trimethyl-2,4-oxazolidinedione; Absentol; Edion; Epidione; Epixal;Minoaleviatin; NSC 15799; NSC 169503; Petidion; Petidon; Petilep; Pitmal;Ptimal; Tridion; Tridione; Tridone; Trimedal; Trimetadione; Trimethadion;Trimethadione; Trimethin; Trimetin; Trioxanona; Troxidone
Density:	1.171g/cm³
Melting Point:	45-46°C
Boiling Point:	78-80°C 5mm
Flash Point:	48°C
Solubility:	Soluble in water 50 g/L.
Hazard Symbols:	May have adverse side effects; toxic in overdose.
Risk Codes:	61-20/21/22
Safety:	Human poison by unspecified routes. Moderately toxic experimentally by ingestion, subcutaneous, intraperitoneal, and intravenous routes. An experimental teratogen. Human reproductive effects by ingestion: effects on newborn, including physical and other postnatal measures or effects. Human teratogenic effects by ingestion: developmental abnormalities of the craniofacial, musculoskeletal, cardiovascular, and urogenital systems. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NO_x. See also KETONES.
PSA:	46.61000
LogP:	0.31150

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Chemistry

The IUPAC name of Trimethadione (CAS NO.127-48-0): 3,5,5-Trimethyl-1,3-oxazolidine-2,4-dione
Synonyms: 2,4-Oxazolidinedione, 3,5,5-trimethyl- ; 3,3,5-Trimethyl-2,4-diketooxazolidine ; 3,5,5-Trimethyl-2,4-oxazolidinedione ; 3,5,5-Trojmetylooksazolidyno-2,4-dion ; 3,5,5-Trojmetylooksazolidyno-2,4-dion [Polish] ; 4-27-00-03237 (Beilstein Handbook Reference) ; Absentol ; Absetil ; Convenixa ; Convexina ; Edion ; Epidione ; Epixal ; Minoaleviatin ; Petidion ; Petidon ; Tioxanona ; Tridilona ; Trimethin ; Trimethinum ; Trimetin ; Trioksal ; Trioxanona
CAS: 127-48-0
EINECS: 204-845-8
Molecular Formula: C₆H₉NO₃
Formula Weight: 143.14 g/mol
Molecular Structure:

Index of Refraction: 1.408
Density: 0.724 g/cm³
Melting point: 45-46°C
Flash Point: 32.8 °C
Boiling Point: 147.3 °C at 760 mmHg

Toxicity Data With Reference

The toxicity of Trimethadione (CAS NO.127-48-0):

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
cat	LDLo	intraperitoneal	2gm/kg (2000mg/kg)	BEHAVIORAL: SLEEP	Journal of Laboratory and Clinical Medicine. Vol. 31, Pg. 1330, 1946.
man	LDLo	unreported	88mg/kg (88mg/kg)		"Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970Vol. 2, Pg. 73, 1970.
mouse	LD₅₀	intraperitoneal	2gm/kg (2000mg/kg)		Journal of Pharmacology and Experimental Therapeutics. Vol. 134, Pg. 60, 1961.
mouse	LD₅₀	intravenous	2gm/kg (2000mg/kg)		Journal of Laboratory and Clinical Medicine. Vol. 31, Pg. 1330, 1946.
mouse	LD₅₀	oral	2100mg/kg (2100mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 23, Pg. 377, 1973.
mouse	LD₅₀	subcutaneous	> 1gm/kg (1000mg/kg)		British Journal of Pharmacology and Chemotherapy. Vol. 11, Pg. 141, 1956.
mouse	LD₅₀	unreported	2170mg/kg (2170mg/kg)		United States Patent Document. Vol. #4056540,
rabbit	LD₅₀	intraperitoneal	1500mg/kg (1500mg/kg)		Journal of Laboratory and Clinical Medicine. Vol. 31, Pg. 1330, 1946.
rabbit	LD₅₀	intravenous	1500mg/kg (1500mg/kg)		Journal of Laboratory and Clinical Medicine. Vol. 31, Pg. 1330, 1946.
rat	LD₅₀	intraperitoneal	280mg/kg (280mg/kg)		Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 9, Pg. 759, 1967.
rat	LD₅₀	intravenous	160mg/kg (160mg/kg)		Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 9, Pg. 759, 1967.
rat	LD₅₀	oral	2140mg/kg (2140mg/kg)		Journal of Pharmacology and Experimental Therapeutics. Vol. 138, Pg. 224, 1962.
rat	LD₅₀	subcutaneous	2gm/kg (2000mg/kg)		"Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 312, 1972.

Safety Profile

The Hazard Codes of Trimethadione (CAS NO.127-48-0): Toxic T
Risk Statements: R61:May cause harm to the unborn child. R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
Safety Statements: S53:Avoid exposure - obtain special instructions before use. S22:Do not breathe dust. S36/37/39:Wear suitable protective clothing, gloves and eye/face protection. S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
WGK Germany: 3
RTECS: RQ2100000
Human poison by unspecified routes. Moderately toxic experimentally by ingestion, subcutaneous, intraperitoneal, and intravenous routes. An experimental teratogen. Human reproductive effects by ingestion: effects on newborn, including physical and other postnatal measures or effects. Human teratogenic effects by ingestion: developmental abnormalities of the craniofacial, musculoskeletal, cardiovascular, and urogenital systems. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NO_x. See also KETONES.