CAS No.129-20-4,OXYPHENYL BUTAZONE Suppliers

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Basic Information

Molecular Structure:
CAS No.:	129-20-4
Name:	OXYPHENYL BUTAZONE
Article Data:	5

Formula:	C19H20 N2 O3
Molecular Weight:	324.379
Synonyms:	3,5-Pyrazolidinedione,4-butyl-1-(p-hydroxyphenyl)-2-phenyl- (6CI,7CI,8CI); 1-(p-Hydroxyphenyl)-2-phenyl-4-butyl-3,5-pyrazolidinedione;1-Phenyl-2-(p-hydroxyphenyl)-3,5-dioxo-4-butylpyrazolidine;1-Phenyl-2-(p-hydroxyphenyl)-3,5-dioxo-4-n-butylpyrazolidine;1-p-Hydroxyphenyl-2-phenyl-3,5-dioxo-4-n-butylpyrazolidine;4-Butyl-2-(4-hydroxyphenyl)-1-phenyl-3,5-dioxopyrazolidine;4-Butyl-2-(p-hydroxyphenyl)-1-phenyl-3,4-pyrazolidinedione;4-Butyl-2-(p-hydroxyphenyl)-1-phenyl-3,5-pyrazolidinedione; Butapirone;Californit; Crovaril; Flamaril; Floghene; Flogitolo; Flogoril; Frabel; G 27202;Metabolite I; NSC 526053; Neo-Farmadol; Offitril; Oxalid; Oxazolidin;Oxyphenbutazone; Oxyphenobutazone; Oxyphenylbutazone; Rapostan; Ro 04-4410;Romaxin; Suganril; Tandacote; Tandearil; Tanderil; Telidal; Tendearil;Visubutina; p-Hydroxyphenylbutazone; p-Oxyphenylbutazone
EINECS:	204-936-2
Density:	1.241g/cm³
Melting Point:	109-111°C
Boiling Point:	485.6°Cat760mmHg
Flash Point:	247.5°C
Solubility:	20mg/L(room temperature)
Hazard Symbols:	Xn,N
Risk Codes:	22-50
Safety:	A poison by ingestion, intraperitoneal, and intravenous routes. Moderately toxic to humans by ingestion. Human systemic effects: agranulocytosis, dermatitis, diarrhea, fever, hemorrhage, hepatitis, hypermotility, nausea or vomiting, salivary gland changes, thrombocytopenia. Experimental reproductive effects. Questionable carcinogen. Mutation data reported. Used as an anti-inflammatory agent. When heated to decomposition it emits toxic fumes of NO_x.
PSA:	60.85000
LogP:	3.62340

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Chemistry

Product Name: Oxyphenbutazone (CAS NO.129-20-4)

Molecular Formula: C₁₉H₂₀N₂O₃
Molecular Weight: 324.37g/mol
Mol File: 129-20-4.mol
Einecs: 204-936-2
Boiling point: 485.6 °C at 760 mmHg
Flash Point: 247.5 °C
Density: 1.241 g/cm³
Surface Tension: 52.9 dyne/cm
Enthalpy of Vaporization: 77.97 kJ/mol
Vapour Pressure: 4.7E-10 mmHg at 25°C
XLogP3-AA: 2.7
H-Bond Donor: 1
H-Bond Acceptor: 3
Structure Descriptors of Oxyphenbutazone (CAS NO.129-20-4):
IUPAC Name: 4-butyl-1-(4-hydroxyphenyl)-2-phenylpyrazolidine-3,5-dione
Canonical SMILES: CCCCC1C(=O)N(N(C1=O)C2=CC=C(C=C2)O)C3=CC=CC=C3
InChI: InChI=1S/C19H20N2O3/c1-2-3-9-17-18(23)20(14-7-5-4-6-8-14)21(19(17)24)15-10-12-16(22)13-11-15/h4-8,10-13,17,22H,2-3,9H2,1H3
InChIKey: HFHZKZSRXITVMK-UHFFFAOYSA-N
Product Categories: Active Pharmaceutical Ingredients; Aromatics; Heterocycles; Intermediates & Fine Chemicals; Pharmaceuticals

Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
child	LDLo	oral	420mg/kg/4W-I (420mg/kg)	LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), DIFFUSE" BLOOD: AGRANULOCYTOSIS BLOOD: THROMBOCYTOPENIA	British Medical Journal. Vol. 2, Pg. 1517, 1962.
dog	LD50	intravenous	178mg/kg (178mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Archives Internationales de Pharmacodynamie et de Therapie. Vol. 149, Pg. 571, 1964.
guinea pig	LD50	oral	1165mg/kg (1165mg/kg)		Pharmacology: International Journal of Experimental and Clinical Pharmacology. Vol. 11, Pg. 220, 1974.
hamster	LD50	oral	1180mg/kg (1180mg/kg)		Archives of Toxicology, Supplement. Vol. 7, Pg. 365, 1984.
man	TDLo	oral	27mg/kg/14D (27mg/kg)	GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" GASTROINTESTINAL: NAUSEA OR VOMITING BLOOD: HEMORRHAGE	Laekartidningen. Medical News. Vol. 63, Pg. 53, 1966.
mouse	LD50	intraperitoneal	100mg/kg (100mg/kg)		National Technical Information Service. Vol. AD414-344,
mouse	LD50	intravenous	52mg/kg (52mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Arzneimittel-Forschung. Drug Research. Vol. 10, Pg. 129, 1960.
mouse	LD50	oral	330mg/kg (330mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 63, Pg. 43, 1967.
rabbit	LD50	intravenous	104mg/kg (104mg/kg)	BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS BEHAVIORAL: EXCITEMENT LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION	Annals of the New York Academy of Sciences. Vol. 86, Pg. 263, 1960.
rat	LD50	intraperitoneal	145mg/kg (145mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 63, Pg. 43, 1967.
rat	LD50	intravenous	68mg/kg (68mg/kg)		Medicina Experimentalis. Vol. 6, Pg. 88, 1962.
rat	LD50	oral	329mg/kg (329mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 63, Pg. 43, 1967.
women	TDLo	oral	24mg/kg/4D (24mg/kg)	GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS ENDOCRINE: OTHER CHANGES	JAMA, Journal of the American Medical Association. Vol. 238, Pg. 1399, 1977.
women	TDLo	oral	50mg/kg/7D (50mg/kg)	SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"	Laekartidningen. Medical News. Vol. 63, Pg. 53, 1966.

Consensus Reports

IARC Cancer Review: Group 3 IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 , 1987,p. 56.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 13 , 1977,p. 183.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) .

Safety Profile

A poison by ingestion, intraperitoneal, and intravenous routes. Moderately toxic to humans by ingestion. Human systemic effects: agranulocytosis, dermatitis, diarrhea, fever, hemorrhage, hepatitis, hypermotility, nausea or vomiting, salivary gland changes, thrombocytopenia. Experimental reproductive effects. Questionable carcinogen. Mutation data reported. Used as an anti-inflammatory agent. When heated to decomposition it emits toxic fumes of NO_x.

Specification

Oxyphenbutazone ,its CAS NO. is 129-20-4,the synonyms is 1-(p-Hydroxyphenyl)-2-phenyl-4-butyl-3,5-pyrazolidinedione ; 1-Phenyl-2-(p-hydroxyphenyl)-3,5-dioxo-4-butylpyrazolidine ; 1-p-Hydroxyphenyl-2-phenyl-3,5-dioxo-4-N-butylpyrazolidine ; 3,5-Dioxo-1-phenyl-2-(p-hydroxyphenyl)-4-N-butylpyrazolidene ; 3,5-Pyrazolidinedione, 4-butyl-1-(4-hydroxyphenyl)-2-phenyl ; 4-Butyl-1-(4-hydroxyphenyl)-2-phenyl-3,5-pyrazolidinedione ; Aradinum ; Artroflog ; Butapirone ; Californit ; Etrozolidina ; Flamaril ; Flegmostam ; Hydroxyphenylbutazon ; Idrobutazina ; Metabolite I ; Oxyphenbutazone anhydrous ; Oxyphenbutazonum ; p-Hydroxyphenylbutazone ; p-Oxyphenylbutazone .