CAS No.133343-34-7,LACTACYSTIN Suppliers,MSDS download

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Basic Information

Molecular Structure:
CAS No.:	133343-34-7
Name:	LACTACYSTIN
Article Data:	17

Formula:	C₁₅H₂₄N₂O₇S
Molecular Weight:	376.431
Synonyms:	LACTACYSTIN; Lactacystin; (+)-Lactacystin;
EINECS:	200-258-5
Density:	1.367 g/cm³
Melting Point:	233-235 ºC
Boiling Point:	714.875 °C at 760 mmHg
Flash Point:	386.143 °C
Appearance:	White powder
PSA:	178.33000
LogP:	-0.56230

Total:27 Page 1 of 1 1

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Specification

The L-Cysteine,N-acetyl-S-[(3S,4R)-3-hydroxy-2-[(1S)-1-hydroxy-2-methylpropyl]-4-methyl-5-oxo-D-prolyl]-, with the CAS registry number 133343-34-7, is also known as L-Cysteine, N-acetyl-,3-hydroxy-2-(1-hydroxy-2-methylpropyl)-4-methyl-5-oxo-2-pyrrolidinecarboxylate(ester), [2R-[2a,2(S*),3a,4a]]-. It belongs to the product categories of All Inhibitors; Inhibitors; Metabolites; Calpain and Proteasome Inhibitors Proteasome, Calpain and Lysosomal Proteases; Inhibitors Protease Inhibitors; Intracellular Protein Degradation; Nitric Oxide and Cell Stress; P to; Protease Inhibitor Specificity Index; Proteasome Inhibitor; Proteasome Inhibitor Enzyme Inhibitors by Enzyme; Proteasomes and Protease. This chemical's molecular formula is C₁₅H₂₄N₂O₇S and molecular weight is 376.43. What's more, both its IUPAC name and systematic name are the same which is called (2R)-2-Acetamido-3-[(2R,3S,4R)-3-hydroxy-2-[(1S)-1-hydroxy-2-methyl-propyl]-4-methyl-5-oxo-pyrrolidine-2-carbonyl]sulfanyl-propanoic acid. It is an organic compound naturally synthesized by bacteria of the genus Streptomyces first described in 1991. The molecule is a lactam, or cyclic amide. A number of syntheses of this molecule have been published. L-Cysteine,N-acetyl-S-[(3S,4R)-3-hydroxy-2-[(1S)-1-hydroxy-2-methylpropyl]-4-methyl-5-oxo-D-prolyl]- is white Powder and can be used a selective and potent inhibitor of proteasome-mediated degradation of ubiquitin-tagged proteins and a Streptomyces metabolite that acts as a highly specific inhibitor of the 20S proteasome. In addition, the classification codes are Anti-Bacterial Agents; Anti-Infective Agents; Cysteine Proteinase Inhibitors; Enzyme Inhibitors and Protease Inhibitors.

Physical properties about L-Cysteine,N-acetyl-S-[(3S,4R)-3-hydroxy-2-[(1S)-1-hydroxy-2-methylpropyl]-4-methyl-5-oxo-D-prolyl]- are: (1) ACD/LogP: 0.09; (2) # of Rule of 5 Violations: 1; (3) ACD/BCF (pH 5.5): 1; (4) ACD/BCF (pH 7.4): 1; (5)ACD/KOC (pH 5.5): 1; (6) ACD/KOC (pH 7.4): 1; (7) #H bond acceptors: 9; (8) #H bond donors: 5; (9) #Freely Rotating Bonds: 10; (10) Polar Surface Area: 178.33 Å²; (11) Index of Refraction: 1.56; (12) Molar Refractivity: 89.002 cm³; (13) Molar Volume: 275.339 cm³; (14) Surface Tension: 60.549 dyne/cm; (15) Density: 1.367 g/cm³; (16) Flash Point: 386.143 °C; (17) Enthalpy of Vaporization: 119.383 kJ/mol; (18) Boiling Point: 714.875 °C at 760 mmHg; (19) Vapour Pressure: 0 mmHg at 25 °C; (20) Melting Point: 233-235 °C.

You can still convert the following datas into molecular structure:
(1) SMILES: C[C@@H]1[C@@H]([C@](NC1=O)([C@H](C(C)C)O)C(=O)SC[C@@H](C(=O)O)NC(=O)C)O
(2) InChI: InChI=1/C15H24N2O7S/c1-6(2)10(19)15(11(20)7(3)12(21)17-15)14(24)25-5-9(13(22)23)16-8(4)18/h6-7,9-11,19-20H,5H2,1-4H3,(H,16,18)(H,17,21)(H,22,23)/t7-,9+,10+,11+,15-/m1/s1
(3) InChIKey: DAQAKHDKYAWHCG-RWTHQLGUBM