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143-85-1

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Basic Information
CAS No.: 143-85-1
Name: 2-chloro-1-{1-[hydroxy(diphenyl)methyl]piperidin-4-yl}ethanone
Article Data: 3
Molecular Structure:
Molecular Structure of 143-85-1 (2-chloro-1-{1-[hydroxy(diphenyl)methyl]piperidin-4-yl}ethanone)
Formula: C20H22 Cl N O2
Molecular Weight: 343.853
Synonyms: 4-Piperidinemethanol,1-(chloroacetyl)-a,a-diphenyl- (6CI,7CI,8CI,9CI)
Density: 1.228g/cm3
Boiling Point: 479°Cat760mmHg
Flash Point: 243.5°C
Safety: A poison by intraperitoneal route. A flammable liquid. When heated to decomposition it emits toxic vapors of NOx and Cl−.
PSA: 40.54000
LogP: 3.33780
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    Ethanone,2-chloro-1-[4-(hydroxydiphenylmethyl)-1-piperidinyl]-

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    Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

    Hangyu Biotech is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and O

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    China (Mainland)  |  Contact Details

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Chemistry

Molecular Structure of 1-Chloroacetyl-α-α-diphenyl-4-piperidinemethanol (CAS NO.143-85-1):


IUPAC: 2-Chloro-1-[1-(hydroxy-diphenyl-methyl)-4-piperidyl]ethanone
Molecular Formula:C20H22ClNO2 
Density:1.228 g/cm3
Flash Point:243.5oC 
Boiling Point:479oC at 760 mmHg
SMILES:ClCC(=O)C3CCN(C(O)(c1ccccc1)c2ccccc2)CC3 
InChI:InChI=1/C20H22ClNO2/c21-15-19(23)16-11-13-22(14-12-16)20(24,17-7-3-1-4-8-17)18-9-5-2-6-10-18/h1-10,16,24H,11-15H2 
InChIKey:OXKRHUJDYNUUBQ-UHFFFAOYAE 
Index of Refraction:1.596
Molar Volume:279.9 cm3
Surface Tension:51.6 dyne/cm
Molar Refractivity:95.35 cm3
Enthalpy of Vaporization:78.29 kJ/mol
Vapour Pressure:5.51E-10 mmHg at 25oC

Toxicity Data With Reference

1.    

ipr-mus LD50:20 mg/kg

     JPMSAE    Journal of Pharmaceutical Sciences. 55 (1966),529.

Safety Profile

A poison by intraperitoneal route. A flammable liquid. When heated to decomposition it emits toxic vapors of NOx and Cl−.

Standards and Recommendations

DOT Classification:  3; Label: Flammable Liquid

Specification

 1-Chloroacetyl-α-α-diphenyl-4-piperidinemethanol with cas registry number of 143-85-1 is also known as 4-Piperidinemethanol,1-chloroacetyl-alpha,alpha-diphenyl- ; Ketone,chloromethyl 4-(diphenylhydroxymethyl)piperidino . This compound should be stored in a cool, dry place when not in use. 1-Chloroacetyl-α-α-diphenyl-4-piperidinemethanol with cas registry number of 143-85-1 is used as an anti-cancer agent. It also used as a pharmaceutical intermediate.