CAS No.1438-30-8,NETROPSIN Suppliers

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Basic Information

Molecular Structure:
CAS No.:	1438-30-8
Name:	NETROPSIN

Formula:	C18H26 N10 O3
Molecular Weight:	430.47
Synonyms:	1H-Pyrrole-2-carboxamide,4-[[[(aminoiminomethyl)amino]acetyl]amino]-N-[5-[[(3-amino-3-iminopropyl)amino]carbonyl]-1-methyl-1H-pyrrol-3-yl]-1-methyl-(9CI);Congocidine (6CI);N,4'-Bi[pyrrole-2-carboxamide],N'-(2-amidinoethyl)-4-(2-guanidinoacetamido)-1,1'-dimethyl- (7CI,8CI);Congocidin;IA 887;NCI 3067;NSC 3067;Netropsin;Sinanomycin;T 1384;
EINECS:	634-294-2
Density:	1.52g/cm³
Melting Point:	171-173℃
Boiling Point:	°Cat760mmHg
Flash Point:	°C
Hazard Symbols:
Risk Codes:	22
Safety:	A poison by ingestion, intraperitoneal, subcutaneous, and intravenous routes. Mutation data reported. When heated to decomposition it emits toxic fumes of NO_x.
PSA:	208.93000
LogP:	1.62120

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Chemistry

Product Name: Netropsin
CAS: 1438-30-8
The Molecular formula of Netropsin (CAS NO.1438-30-8): C₁₈H₂₆N₁₀O₃
The Molecular Weight of Netropsin (CAS NO.1438-30-8): 430.46
The Molecular Structure of Netropsin (CAS NO.1438-30-8):

Density: 1.52 g/cm³
Index of Refraction: 1.709
Molar Refractivity: 110.37 cm³
Molar Volume: 282.7 cm³
Polarizability: 43.75×10^-24cm³
Surface Tension: 69.9 dyne/cm
Appearance: Faint yellow powder
Water Solubility: 1.158e+005 (mg/L) at 25°C

Toxicity Data With Reference

1.	dnd-omi 200 µmol	EJBCAI European Journal of Biochemistry. 26 (1972),81.
2.	dnd-omi 200 µmol	EJBCAI European Journal of Biochemistry. 26 (1972),81.
3.	orl-mus LD50: 300 mg/kg	85ERAY Antibiotics: Origin, Nature, and Properties. 2 (1978),1180.
4.	ipr-mus LDLo:50 mg/kg	JAJAAA Journal of Antibiotics, Series A. 9 (1956),102.
5.	scu-mus LD50: 70 mg/kg	85ERAY Antibiotics: Origin, Nature, and Properties. 2 (1978),1180.
6.	ivn-mus LD50: 17 mg/kg	85ERAY Antibiotics: Origin, Nature, and Properties. 2 (1978),1180.

Safety Profile

A poison by ingestion, intraperitoneal, subcutaneous, and intravenous routes. Mutation data reported. When heated to decomposition it emits toxic fumes of NO_x.
Safety Information about Netropsin (CAS NO.1438-30-8):
Hazard Codes:
Xn:
Risk Statements about Netropsin (CAS NO.1438-30-8):
R22: Harmful if swallowed.
Safety Statements about Netropsin (CAS NO.1438-30-8):
S36: Wear suitable protective clothing.
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
RTECS: DW2973000

Specification

Netropsin with CAS number of 1438-30-8 is also known as 2814-A ; 4-22-00-06712 (Beilstein Handbook Reference) ; Antibiotic 1142 ; Antibiotic T-1384 ; BRN 0376913 ; CH-777-A ; Congocidin ; Congocidine ; Netropsin ; Sinanomycin .It shoud be storaged at −20°C. Netropsin binds to the minor groove of AT-rich sequences of double stranded DNA . In contrast, Netropsin does not bind single stranded DNA or double stranded RNA. Crystallographic structures of DNA-bound Netropsin have been obtained and elucidate details of how the drug binds in the minor groove . In the bound structure, the drug makes hydrogen bonding interactions with four subsequent base pairs of the DNA duplex, locally displacing the water molecules of the spine of hydration. It has been shown that Netropsin is active both against Gram-positive bacteria and Gram-negative bacteria.