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| CAS No.: | 151-73-5 |
|---|---|
| Name: | Betamethasone 21-phosphate disodium |
| Molecular Structure: | |
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|
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| Formula: | C22H28FNa2O8P |
| Molecular Weight: | 516.41 |
| Synonyms: | Pregna-1,4-diene-3,20-dione,9-fluoro-11,17-dihydroxy-16-methyl-21-(phosphonooxy)-, disodium salt, (11b,16b)- (9CI);Bentelan;Betamethasone 21-phosphate disodium salt;Betnesol;Celestan solubile;Disodium betamethasone 21-phosphate;Durabetason;NSC 90616;Steronema;Vista-Methasone; |
| EINECS: | 205-797-0 |
| Boiling Point: | 669.6 °C at 760 mmHg |
| Flash Point: | 358.7 °C |
| Appearance: | white powder |
| Hazard Symbols: |
 Xn
|
| Risk Codes: | 22 |
| Safety: | 36 |
| PSA: | 156.83000 |
| LogP: | 2.88910 |
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Chemistry
Molecular Structure:
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Molecular Formula: C22H28FNa2O8P
Molecular Weight: 516.4046
IUPAC Name: Disodium [2-[(8S,9R,10S,11S,13S,14S,16S,17R)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] phosphate
Synonyms of Betamethasone disodium phosphate (CAS NO.151-73-5): 9-Fluoro-11beta,17,21-trihydroxy-16beta-methylpregna-1,4-diene-3,20-dione 21-(disodium phosphate) ; BDP ; Bentelan ; Betamethasone 21-disodium phosphate ; Betamethasone sodium phosphate ; Betamethazone disodium phosphate ; Betasone (Veterinary) ; Betavet Soluspan (Veterinary) ; Betnesol ; Celestone ; Celestone Phosphate ; Celestone Phosphate Injection ; Disodium betamethasone 21-phosphate ; EINECS 205-797-0 ; Linolosal ; Linosal ; NSC 90616 ; UNII-7BK02SCL3W ; beta-Methasone disodium phosphate ; beta-Methasone phosphate ; beta-Methasone sodium phosphate ; beta-Methasone, disodium phosphate ; Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17-dihydroxy-16-methyl-21-(phosphonooxy)-, disodium salt, (11beta,16beta)- ; Pregna-1,4-diene-3,20-dione, 9-fluoro-11-beta,17,21-trihydroxy-16-beta-methyl-, 21-(dihydrogen phosphate), disodium salt ; Pregna-1,4-diene-3,20-dione, 9-fluoro-11beta,17,21-trihydroxy-16beta-methyl-, 21-(dihydrogen phosphate), disodium salt (8CI)
CAS NO: 151-73-5
Classification Code: Adrenal Cortex Hormones ; Glucocorticoid ; Glucocorticoids ; Hormone ; Hormones ; Hormones, Hormone Substitutes, and Hormone Antagonists ; Reproductive Effect
H bond acceptors: 8
H bond donors: 4
Freely Rotating Bonds: 6
Polar Surface Area: 129.17 ?2
Flash Point: 358.7 °C
Enthalpy of Vaporization: 112.61 kJ/mol
Boiling Point: 669.6 °C at 760 mmHg
Vapour Pressure: 8.62E-21 mmHg at 25°C
Uses
Betamethasone disodium phosphate (CAS NO.151-73-5) is a kind of hormonal medicines which has anti-inflammatory effects.
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intraperitoneal | 1166mg/kg (1166mg/kg) | Shikoku Igaku Zasshi. Shikoku Medical Journal. Vol. 29, Pg. 153, 1973. | |
| mouse | LD50 | intravenous | 1304mg/kg (1304mg/kg) | Drugs in Japan Vol. -, Pg. 1075, 1990. | |
| mouse | LD50 | oral | 1607mg/kg (1607mg/kg) | Shikoku Igaku Zasshi. Shikoku Medical Journal. Vol. 29, Pg. 153, 1973. | |
| mouse | LD50 | subcutaneous | 1363mg/kg (1363mg/kg) | Shikoku Igaku Zasshi. Shikoku Medical Journal. Vol. 29, Pg. 153, 1973. | |
| rat | LD50 | intramuscular | 1291mg/kg (1291mg/kg) | Drugs in Japan Vol. -, Pg. 1075, 1990. | |
| rat | LD50 | intraperitoneal | 1179mg/kg (1179mg/kg) | Drugs in Japan Vol. -, Pg. 1075, 1990. | |
| rat | LD50 | intravenous | 1276mg/kg (1276mg/kg) | Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 21, Pg. 2117, 1979. | |
| rat | LD50 | oral | 1877mg/kg (1877mg/kg) | Drugs in Japan Vol. -, Pg. 1075, 1990. | |
| rat | LD50 | subcutaneous | 1265mg/kg (1265mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Oyo Yakuri. Pharmacometrics. Vol. 52, Pg. 105, 1996. |
Safety Profile
The safety information of Betamethasone disodium phosphate (CAS NO.151-73-5) is as follows:
Hazard Codes: Xn 
Risk Statements: 22
22: Harmful if swallowed
Safety Statements: 36
36: Wear suitable protective clothing
WGK Germany: 3
RTECS: TU4056500
Moderately toxic by ingestion and other routes. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits toxic fumes of F−, POx and Na2O.