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| CAS No.: | 16561-29-8 |
|---|---|
| Name: | PHORBOL 12-MYRISTATE 13-ACETATE |
| Article Data: | 1 |
| Molecular Structure: | |
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| Formula: | C36H56 O8 |
| Molecular Weight: | 616.836 |
| Synonyms: | Myristicacid, 9-ester with 1,1aa,1bb,4,4a,7aa,7b,8,9,9a-decahydro-4ab,7ba,9b,9aa-tetrahydroxy-3-(hydroxymethyl)-1,1,6,8a-tetramethyl-5H-cyclopropa[3,4]benz[1,2-e]azulen-5-one9a-acetate, (+)- (8CI); Tetradecanoic acid,9a-(acetyloxy)-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1H-cyclopropa[3,4]benz[1,2-e]azulen-9-ylester, [1aR-(1aa,1bb,4ab,7aa,7ba,8a,9b,9aa)]-;1H-Cyclopropa[3,4]benz[1,2-e]azulene, tetradecanoic acid deriv.;12-O-Tetradecanoylphorbol 13-acetate; 12-Tetradecanoylphorbol 13-acetate;12-Tetradecanoylphorbol 13-monoacetate; 13-O-Acetylphorbol 12-myristate; 4b-Phorbol 12-myristate 13-acetate;Factor A1; Factor A1 (croton oil); NSC 262244; PMA; PMA (tumor promoter);Phorbol 12-myristate 13-acetate; Phorbol 12-tetradecanoate 13-acetate; Phorbolmyristate acetate; TPA; TPA (phorbol derivative); b-Phorbol 12-myristate 13-acetate |
| EINECS: | 16561-29-8 |
| Density: | 1.17 g/cm3 |
| Boiling Point: | 698.1 °C at 760 mmHg |
| Flash Point: | 208.1 °C |
| Solubility: | Soluble in DMSO, methanol, 100% ethanol, acetone, ether or dimethylformamide; almost insoluble in aqueous buffers. |
| Appearance: | White to off-white solid. |
| Hazard Symbols: |
 Xi
|
| Risk Codes: | 38 |
| Safety: | 36/37 |
| PSA: | 130.36000 |
| LogP: | 5.75290 |
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Chemistry
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Systematic Name: (1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-9a-(acetyloxy)-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-1H-cyclopropa[3,4]benzo[1,2-e]azulen-9-yl tetradecanoate
Molecular Formula: C36H56O8
Molecular Weight: 616.83 g/mol
Classification Code: Carcinogens; Mutation data; Noxae; Reproductive Effect; Skin / Eye Irritant; Tumor data
storage temperature: -20 °C
Index of Refraction: 1.553
Molar Refractivity: 168.29 cm3
Molar Volume: 525.6 cm3
Surface Tension: 50.9 dyne/cm
Density: 1.17 g/cm3
Flash Point: 208.1 °C
Enthalpy of Vaporization: 116.86 kJ/mol
Boiling Point: 698.1 °C at 760 mmHg
solubility: DMSO: DMSO solutions can be stored dark at −20?#x00b0;C for at least six months.soluble
Vapour Pressure of Phorbol myristate acetate (CAS NO.16561-29-8): 1.55E-22 mmHg at 25 °C
Uses
Phorbol myristate acetate (CAS NO.16561-29-8) has a specific use in cancer diagnostics as a B-cell specific mitogen in cytogenetic testing. To view the chromosomes, a cytogenetic test requires dividing cells. It is used to stimulate division of B-cells during cytogenetic diagnosis of B-cell cancers such as chronic lymphocytic leukemia.
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| domestic animals - goat/sheep | LDLo | intravenous | 40ug/kg (0.04mg/kg) | LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES BLOOD: CHANGES IN LEUCOCYTE (WBC) COUNT BLOOD: CHANGES IN PLATELET COUNT | Journal of Applied Physiology. Vol. 54, Pg. 267, 1983. |
| mouse | LD | intraperitoneal | > 1mg/kg (1mg/kg) | Toxicon. Vol. 38, Pg. 123, 2000. | |
| mouse | LD50 | intravenous | 309ug/kg (0.309mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) SKIN AND APPENDAGES (SKIN): HAIR: OTHER | Agents and Actions, A Swiss Journal of Pharmacology. Vol. 16, Pg. 535, 1985. |
Consensus Reports
EPA Genetic Toxicology Program.
Safety Profile
Deadly poison by intravenous route. An experimental teratogen. Experimental reproductive effects. Human mutation data reported. A skin irritant. Questionable carcinogen with experimental carcinogenic, neoplastigenic, and tumorigenic data. When heated to decomposition it emits acrid smoke and irritating fumes.
Hazard Codes: 
Xi
Risk Statements: 38
R38:Irritating to skin.
Safety Statements: 36/37
S36/37:Wear suitable protective clothing and gloves.
RIDADR: 2928
WGK Germany: 3
RTECS: QH4377000
HazardClass: 6.1(a)
PackingGroup of Phorbol myristate acetate (CAS NO.16561-29-8): II
Analytical Methods
Tested for stimulation of interleukin production in Jurkat cells.
Specification
Phorbol myristate acetate (CAS NO.16561-29-8), its Synonyms are Tetradecanoylphorbol acetate ; 12-O-Tetradecanoyl phorbol acetate ; 12-O-Tetradecanoylphorbol 13-acetate ; 12-O-Tetradecanoylphorbol-13-acetate ; 13-O-Acetylphorbol 12-myristate ; 13-Tetradecanoylphorbol acetate ; 4beta-Phorbol 12-myristate 13-acetate . It is white to off-white solid.