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CAS No.: | 17146-95-1 |
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Name: | lactic acid, compound with (2α,6α,11R*)-1,2,3,4,5,6-hexahydro-6,11-dimethyl-3-(3-methylbut-2-enyl)-2,6-methano-3-benzocin-8-ol (1:1) |
Molecular Structure: | |
Formula: | C19H27NO•C3H6O3 |
Molecular Weight: | 375.56 |
Synonyms: | 2,6-Methano-3-benzazocin-8-ol,1,2,3,4,5,6-hexahydro-6,11-dimethyl-3-(3-methyl-2-butenyl)-,hydrochloride;pentazocine lactate;1,2,3,4,5,6-Hexahydro-6,11-dimethyl-3-(3-methylbut-2-enyl)-2,6-methano-3-benzazocin-8-ol hydrochloride; |
Melting Point: | 145.4-147.2oC |
Boiling Point: | 548.8°C at 760 mmHg |
Flash Point: | 285.7°C |
Hazard Symbols: | A poison. A human skin irritant. |
Safety: | A poison by intraperitoneal route. Human systemic effects. A human skin irritant. When heated to decomposition it emits toxic vapors of NOx. |
PSA: | 49.77000 |
LogP: | 3.40110 |
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Product Name: Pentazocine lactate (CAS NO.17146-95-1)
Molecular Formula: C19H27NO•C3H6O3
Molecular Weight: 375.56g/mol
Mol File: 17146-95-1.mol
EINECS: 241-209-9
Boiling point: 548.8 °C at 760 mmHg
Flash Point: 285.7 °C
Enthalpy of Vaporization: 87.18 kJ/mol
Vapour Pressure: 7.06E-13 mmHg at 25°C
H-Bond Donor: 3
H-Bond Acceptor: 5
Structure Descriptors of Pentazocine lactate (CAS NO.17146-95-1):
Canonical SMILES: CC1C2CC3=C(C1(CCN2CC=C(C)C)C)C=C(C=C3)O.CC(C(=O)O)O
Isomeric SMILES: C[C@H]1[C@H]2CC3=C([C@@]1(CCN2CC=C(C)C)C)C=C(C=C3)O.CC(C(=O)O)O
InChI: InChI=1S/C19H27NO.C3H6O3/c1-13(2)7-9-20-10-8-19(4)14(3)18(20)11-15-5-6-16(21)12-17(15)19;1-2(4)3(5)6/h5-7,12,14,18,21H,8-11H2,1-4H3;2,4H,1H3,(H,5,6)/t14-,18+,19+;/m0./s1
InChIKey: QNLDTXPVZPRSAM-DTOXXUQYSA-N
Pentazocine lactate (CAS NO.17146-95-1) is a CYP450-2D6 inducer that increases the degree of conversion of codeine to morphine (the active metabolite of codeine - a prodrug with no intrinsic activity), in vivo, by approximately a factor of three, increasing the average degree of codeine metabolized to morphine from 10% to 30% - while synergistically adding to the depressant effects of the codeine.
The mu-opioid-antagonist naloxone was added to preparations containing pentazocine, and the reported incidence of its abuse has declined precipitously since. A more recent recreational route is pentazocine combined with methylphenidate (Ritalin) via the oral route, insufflation or mixed intravenously.
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
man | TDLo | parenteral | 16mg/kg/3W-I (16mg/kg) | MUSCULOSKELETAL: OTHER CHANGES | Journal of Rheumatology. Vol. 13, Pg. 210, 1986. |
mouse | LD50 | intraperitoneal | 103mg/kg (103mg/kg) | Journal of Pharmacy and Pharmacology. Vol. 23, Pg. 882, 1971. | |
women | TDLo | subcutaneous | 2mg/kg (2mg/kg) | SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" | Archives of Dermatology. Vol. 123, Pg. 297, 1987. |
A poison by intraperitoneal route. Human systemic effects. A human skin irritant. When heated to decomposition it emits toxic vapors of NOx.
Pentazocine lactate , its CAS NO. is 17146-95-1, the synonyms are (2R*,6R*,11R*)-1,2,3,4,5,6-Hexahydro-6,11-dimethyl-3-(3-methyl-2-butenyl)-2,6-methano-3-benzazocin-8-ol lactate (salt) ; 2-Hydroxypropanoic acid compd. with (2alpha,6alpha,11R*)-1,2,3,4,5,6-hexahydro-6,11-dimethyl-3-(3-methyl-2-butenyl)-2,6-methanol-3-benzocin-8-ol (1:1) ; Liticon ; Pentalgine ; Talwin ; UNII-1P2XIB510O ; 2,6-Methano-3-benzazocin-8-ol, 1,2,3,4,5,6-hexahydro-6,11-dimethyl-3-(3-methyl-2-butenyl)-, (2alpha,6alpha,11R*)-, compd. with 2-hydroxypropanoic acid (1:1) ; Lactic acid, compd. with 1,2,3,4,5,6-hexahydro-6,11-dimethyl-3-(3-methyl-2-butenyl)-2,6-methano-3-benzazocin-8-ol (1:1) ; Lactic acid, compound with (2alpha,6alpha,11R*)-1,2,3,4,5,6-hexahydro-6,11-dimethyl-3-(3-methylbut-2-enyl)-2,6-methano-3-benzocin-8-ol (1:1) ; Propanoic acid, 2-hydroxy-, compd. with (2alpha,6alpha,11R*)-1,2,3,4,5,6-hexahydro-6,11-dimethyl-3-(3-methyl-2-butenyl)-2,6-methanol-3-benzocin-8-ol (1:1) .