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CAS No.: | 17321-77-6 |
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Name: | Clomipramine hydrochloride |
Article Data: | 3 |
Molecular Structure: | |
Formula: | C19H23ClN2.HCl |
Molecular Weight: | 351.319 |
Synonyms: | 5H-Dibenz[b,f]azepine,3-chloro-5-[3-(dimethylamino)propyl]-10,11-dihydro-, monohydrochloride (8CI);5H-Dibenz[b,f]azepine-5-propanamine, 3-chloro-10,11-dihydro-N,N-dimethyl-,monohydrochloride (9CI);3-Chloro-5-(3-dimethylaminopropyl)-10,11-dihydro-5H-dibenz[b,f]azepinehydrochloride;3-Chloroimipramine hydrochloride;Anafranil;Anaphranil;Anatranil;Chloroimipramine monohydrochloride; |
EINECS: | 241-344-3 |
Melting Point: | 189-190 °C |
Boiling Point: | 434.2 °C at 760 mmHg |
Flash Point: | 216.4 °C |
Solubility: | H2O: 25 mg/mL |
Appearance: | off-white solid |
Hazard Symbols: | Xn |
Risk Codes: | 20/21/22 |
Safety: | 36 |
PSA: | 6.48000 |
LogP: | 5.39540 |
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The Chlorimipramine hydrochloride with the cas number 17321-77-6, is also called (1)3-Chloro-5-(3-(dimethylamino)propyl)-10,11-dihydro-5H-dibenz(b,f)azepine monohydrochloride ; (2) 3-Chloroimipramine hydrochloride ; (3) 5H-Dibenz(b,f)azepine-5-propanamine, 3-chloro-10,11-dihydro-; (4)N,N-dimethyl-, monohydrochloride ; (5) Anafranil ; (6) Anaphranil ; (7) Chlorimipramine hydrochloride ; (8) Chloroimipramine monohydrochloride ; (9) Clomicalm ; (10) Clomipramine HCl ; (11) Clomipramine hydrochloride ; (12) EINECS 241-344-3 ; (13) G 34586 ; (14) Hydiphen ; (15) UNII-2LXW0L6GWJ. It belongs to the following product categories such as (1)Organics; (2)Chemical Amines; (3)Amines; (4)Heterocycles; (5)Intermediates & Fine Chemicals; (6)Pharmaceuticals; (7)Serotonin receptor.
Properties of Venlafaxine are: (1)ACD/BCF (pH 5.5): 6.79 ; (2)ACD/BCF (pH 7.4): 76.21 ; (3)ACD/KOC (pH 5.5): 18.76 ; (4)ACD/KOC (pH 7.4): 210.7 ; (5)#H bond acceptors: 2 ; (6)#H bond donors: 0 ; (7)#Freely Rotating Bonds: 4 ; (8)Polar Surface Area: 6.48Å2 ; (9)Flash Point: 216.4 °C ; (10)Enthalpy of Vaporization: 69.03 kJ/mol ; (11)Boiling Point: 434.2 °C at 760 mmHg ; (12)Vapour Pressure: 9.63E-08 mmHg at 25°C
The Chlorimipramine hydrochloride appears to be off-White solid. It is used for serotonin reuptake inhibitor. antidepressant and antiobsessional agent. Chlorimipramine hydrochloride is quite harmful by inhalation, in contact with skin and if swallowed. Hence, in case of such dangerous thing, please wear suitable protective clothing.
You can still convert the following datas into molecular structure :
1. SMILES: Cl.Clc1ccc3c(c1)N(c2ccccc2CC3)CCCN(C)C
2. InChI: InChI=1/C19H23ClN2.ClH/c1-21(2)12-5-13-22-18-7-4-3-6-15(18)8-9-16-10-11-17(20)14-19(16)22;/h3-4,6-7,10-11,14H,5,8-9,12-13H2,1-2H3;1H
The Chlorimipramine hydrochloride toxic data can be showed in the following sheet.
Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source | |
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dog | LD50 | intravenous | 32mg/kg (32mg/kg) | Kiso to Rinsho. Clinical Report. Vol. 4, Pg. 2105, 1970. | |
dog | LD50 | oral | 383mg/kg (383mg/kg) | Kiso to Rinsho. Clinical Report. Vol. 4, Pg. 2105, 1970. | |
dog | LD50 | subcutaneous | > 400mg/kg (400mg/kg) | Kiso to Rinsho. Clinical Report. Vol. 4, Pg. 2105, 1970. | |
mouse | LD50 | intraperitoneal | 90mg/kg (90mg/kg) | Drugs in Japan Vol. 6, Pg. 243, 1982. | |
mouse | LD50 | intravenous | 22mg/kg (22mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: CYANOSIS | European Journal of Pharmacology. Vol. 32, Pg. 108, 1975. |
mouse | LD50 | oral | 470mg/kg (470mg/kg) | Drugs in Japan Vol. 6, Pg. 243, 1982. | |
mouse | LD50 | subcutaneous | 400mg/kg (400mg/kg) | Kiso to Rinsho. Clinical Report. Vol. 4, Pg. 2105, 1970. | |
rabbit | LD50 | intravenous | 12mg/kg (12mg/kg) | Kiso to Rinsho. Clinical Report. Vol. 4, Pg. 2105, 1970. | |
rabbit | LD50 | oral | 792mg/kg (792mg/kg) | Kiso to Rinsho. Clinical Report. Vol. 4, Pg. 2105, 1970. | |
rabbit | LD50 | subcutaneous | 217mg/kg (217mg/kg) | Kiso to Rinsho. Clinical Report. Vol. 4, Pg. 2105, 1970. | |
rat | LD50 | intraperitoneal | 135mg/kg (135mg/kg) | Drugs in Japan Vol. 6, Pg. 243, 1982. | |
rat | LD50 | intravenous | 26mg/kg (26mg/kg) | Drugs in Japan Vol. 6, Pg. 243, 1982. | |
rat | LD50 | oral | 914mg/kg (914mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: CYANOSIS | European Journal of Pharmacology. Vol. 32, Pg. 108, 1975. |
rat | LD50 | subcutaneous | 1750mg/kg (1750mg/kg) | Drugs in Japan Vol. 6, Pg. 243, 1982. | |
women | LDLo | oral | 51mg/kg (51mg/kg) | SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP | Journal of Analytical Toxicology. Vol. 22, Pg. 612, 1998. |
women | TDLo | oral | 9mg/kg/9D-I (9mg/kg) | AUTONOMIC NERVOUS SYSTEM: "SMOOTH MUSCLE RELAXANT (MECHANISM UNDEFINED, SPASMOLYTIC)" BEHAVIORAL: ATAXIA BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) | American Journal of Psychiatry. Vol. 150, Pg. 165, 1993. |
women | TDLo | oral | 170mg/kg (170mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION | Journal of Toxicology, Clinical Toxicology. Vol. 38, Pg. 447, 2000. |
women | TDLo | oral | 360mg/kg/13W- (360mg/kg) | CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP | Journal of Clinical Psychiatry. Vol. 46, Pg. 290, 1985. |