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| CAS No.: | 17617-23-1 |
|---|---|
| Name: | FLURAZEPAM |
| Molecular Structure: | |
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| Formula: | C21H23 Cl F N3 O |
| Molecular Weight: | 387.885 |
| Synonyms: | 2H-1,4-Benzodiazepin-2-one,7-chloro-1-[2-(diethylamino)ethyl]-5-(o-fluorophenyl)-1,3-dihydro- (8CI);7-Chloro-1-(2-diethylaminoethyl)-5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one;7-Chloro-1-[2-(diethylamino)ethyl]-5-(o-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one;Felmane; Flurazepam; Noctosom; Ro 56901/3; Stauroderm |
| Density: | 1.21g/cm3 |
| Melting Point: | 77-82° |
| Boiling Point: | 551.4°Cat760mmHg |
| Flash Point: | 287.2°C |
| Hazard Symbols: |
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| Risk Codes: | 22-33 |
| Safety: | Poison by intravenous routes. Moderately toxic by ingestion and subcutaneous routes. Experimental reproductive effects. Caution: May be habit-forming. This is a controlled substance (depressant) listed in the U.S. Code of Federal Regulations, Title 21 Part 1308.14. When heated to decomposition it emits very toxic fumes of Cl−, F− and NOx. See also DIAZEPAM. |
| PSA: | 35.91000 |
| LogP: | 3.50550 |
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Chemistry
Empirical Formula: C21H23ClFN3O
Molecular Weight: 387.8782 g/mol
EINECS: 241-591-7
Index of Refraction: 1.589
Density: 1.21 g/cm3
Flash Point: 287.2 °C
Boiling Point: 551.4 °C at 760 mmHg
Vapour Pressure: 3.34E-12 mmHg at 25 °C
Appearance: Light yellow solid
Structure of Flurazepam (CAS NO.17617-23-1):
IUPAC Name: 7-Chloro-1-(2-diethylaminoethyl)-5-(2-fluorophenyl)-3H-1,4-benzodiazepin-2-one
Solubility: Easily soluble in Chloroform , soluble in Acetone , Methanol , Ethanol , Glacial acetic acid and Ether , insoluble in Cyclohexane , almost insoluble in water
Uses
Flurazepam (CAS NO.17617-23-1) is a drug which is a benzodiazepine derivative. It is used for short-term treatment of patients with insomnia and is sometimes used in patients who have difficulty in maintaining sleep.
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| cat | LDLo | oral | 250mg/kg (250mg/kg) | Drugs of the Future. Vol. 9, Pg. 152, 1984. | |
| human | TDLo | oral | 380ug/kg (0.38mg/kg) | LUNGS, THORAX, OR RESPIRATION: DYSPNEA LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES | American Journal of Medicine. Vol. 73, Pg. 239, 1982. |
| mouse | LD50 | intraperitoneal | 540mg/kg (540mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION | Oyo Yakuri. Pharmacometrics. Vol. 14, Pg. 637, 1977. |
| mouse | LD50 | intravenous | 59100ug/kg (59.1mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 6, Pg. 530, 1975. | |
| mouse | LD50 | oral | 500mg/kg (500mg/kg) | Therapie. Vol. 26, Pg. 439, 1971. | |
| mouse | LD50 | subcutaneous | 3844mg/kg (3844mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION | Oyo Yakuri. Pharmacometrics. Vol. 14, Pg. 637, 1977. |
| rat | LD50 | intraperitoneal | 600mg/kg (600mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION | Oyo Yakuri. Pharmacometrics. Vol. 14, Pg. 637, 1977. |
| rat | LD50 | intravenous | 38700ug/kg (38.7mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 6, Pg. 530, 1975. | |
| rat | LD50 | oral | 980mg/kg (980mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION | Oyo Yakuri. Pharmacometrics. Vol. 14, Pg. 637, 1977. |
| rat | LD50 | subcutaneous | > 3844mg/kg (3844mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION | Oyo Yakuri. Pharmacometrics. Vol. 14, Pg. 637, 1977. |
Safety Profile
Poison by intravenous routes. Moderately toxic by ingestion and subcutaneous routes. Experimental reproductive effects. Caution: May be habit-forming. This is a controlled substance (depressant) listed in the U.S. Code of Federal Regulations, Title 21 Part 1308.14. When heated to decomposition it emits very toxic fumes of Cl−, F− and NOx. See also DIAZEPAM.
Hazard Codes: 
Xn
Risk Statements: 22-33
R22:Harmful if swallowed.
R33:Danger of cumulative effects.
Safety Statements: 1/2-22-36
S1/2:Keep locked up and out of the reach of children.
S22:Do not breathe dust.
S36:Wear suitable protective clothing.
Specification
Flurazepam ,its cas register number is 17617-23-1. It also can be called Flurazepam hydrochloride ; Dobutamine hydrochloride ; Flurazepam dihydrochloride ; and Dalmane . It produces a metabolite with a very long half-life (40–250 hours), therefore unsuitable as a sleeping medication for some individuals due to next day sedation. Flurazepam (CAS NO.17617-23-1) has abuse potential and should never be used with alcohol or any other substance that can cause drowsiness. And a review paper found that its long term use is associated with drug dependence, drug tolerance, rebound insomnia and CNS related adverse effects. It is contraindicated in pregnancy and is recommended to withdraw flurazepam during breast feeding.