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CAS No.: | 23031-25-6 |
---|---|
Name: | 5-(1-Hydroxy-2-tert-butylamino-ethyl)benzene-1,3-diol |
Article Data: | 13 |
Molecular Structure: | |
Formula: | C12H19NO3 |
Molecular Weight: | 225.288 |
Synonyms: | Benzylalcohol, a-[(tert-butylamino)methyl]-3,5-dihydroxy-(8CI);(?à)-Terbutaline;1-(3,5-Dihydroxyphenyl)-2-(tert-butylamino)ethanol;Aerodur;Brican;Bricar;Bricaril;Bricyn;Fasma;Terbutalin; |
EINECS: | 245-385-8 |
Density: | 1.171 g/cm3 |
Melting Point: | 204-208°C |
Boiling Point: | 419.2 °C at 760 mmHg |
Flash Point: | 165.3 °C |
Transport Information: | UN 3077 9 |
PSA: | 72.72000 |
LogP: | 1.91020 |
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Molecular Structure of Terbutaline (CAS NO.23031-25-6):
IUPAC Name: 5-[2-(tert-butylamino)-1-hydroxyethyl]benzene-1,3-diol
CAS: 23031-25-6
Molecular Formula: C12H19NO3
Molecular Weight: 225.28
EINECS: 245-385-8
H bond acceptors: 4
H bond donors: 4
Freely Rotating Bonds: 7
Polar Surface Area: 30.93 Å2
Molar Refractivity: 63.19 cm3
Molar Volume: 192.2 cm3
Surface Tension: 50 dyne/cm
Density: 1.171 g/cm3
Flash Point: 165.3 °C
Enthalpy of Vaporization: 70.94 kJ/mol
Boiling Point: 419.2 °C at 760 mmHg
Vapour Pressure: 8.92E-08 mmHg at 25°C
InChI
InChI=1/C12H19NO3/c1-12(2,3)13-7-11(16)8-4-9(14)6-10(15)5-8/h4-6,11,13-16H,7H2,1-3H3
Smiles
C(NC[C@@H](c1cc(cc(c1)O)O)O)(C)(C)C
Classification Code: Adrenergic Agents; Adrenergic Agonists; Adrenergic beta-agonists; Anti-Asthmatic Agents; Autonomic Agents; Bronchodilator agents; Drug / Therapeutic Agent; Human Data; Neurotransmitter Agents; Peripheral Nervous System Agents; Reproductive Control Agents; Reproductive Effect; Respiratory System Agents; Sympathomimetics; Tocolytic agents
Terbutaline (CAS NO.23031-25-6) is used as a treatment for premature labour is an off-label use not approved by the FAD. It is apregnancy category 'B' medication and is routinely prescribed to stop contractions. Terbutaline (CAS NO.23031-25-6) is currently on the World Anti-Doping Agency's list of prohibited drugs for Olympic athletes, except when administered by inhalation and a Therapeutic Use Exemption (TUE) has been obtained in advance.Orally disintegrating tablets by sublimation technique of Terbutaline sulphate have been developed.
Terbutaline (CAS NO.23031-25-6) (trade names Brethine, Bricanyl, or Brethaire) is a β2-adrenergic receptor agonist, used as a fast-acting bronchodilator (often used as a short-term asthma treatment) and as a tocolytic to delay premature labour. The inhaled form of terbutaline starts working within 15 minutes and can last up to 6 hours .
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
man | TDLo | oral | 714ug/kg (0.714mg/kg) | BEHAVIORAL: TREMOR CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION) CARDIAC: CHANGE IN RATE | New England Journal of Medicine. Vol. 300, Pg. 143, 1979. |
women | TDLo | multiple routes | 380ug/kg (0.38mg/kg) | CARDIAC: OTHER CHANGES | JAMA, Journal of the American Medical Association. Vol. 244, Pg. 692, 1980. |
Terbutaline , with CAS number of 23031-25-6, can be called 5-(1-Hydroxy-2-tert-butylamino-ethyl)benzene-1,3-diol ; Terbutaline;(R)-α-[(tert-Butylamino)methyl]-3,5-dihydroxybenzyl alcohol ; (S)-α-[(tert-Butylamino)methyl]-3,5-dihydroxybenzyl alcohol ; 5-[(S)-1-Hydroxy-2-(tert-butylamino)ethyl]benzene-1,3-diol ; rac-5-[(R*)-2-[(1,1-Dimethylethyl)amino]-1-hydroxyethyl]-1,3-benzenediol .