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2365-30-2

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Basic Information
CAS No.: 2365-30-2
Name: 1-(2-chloroethyl)-1-nitrosourea
Article Data: 2
Molecular Structure:
Molecular Structure of 2365-30-2 (1-(2-chloroethyl)-1-nitrosourea)
Formula: C3H6 Cl N3 O2
Molecular Weight: 151.553
Synonyms: Urea,1-(2-chloroethyl)-1-nitroso- (7CI,8CI); 1-(2-Chloroethyl)-1-nitrosourea;Chloroethylnitrosourea; N-(2-Chloroethyl)-N-nitrosourea; NSC 47547
Density: 1.56g/cm3
Boiling Point: 241.2°Cat760mmHg
Flash Point: 99.7°C
Safety: Poison by intraperitoneal and intravenous routes. Human mutation data reported. Many N-nitroso compounds are carcinogens. When heated to decomposition it emits very toxic fumes of Cl− and NOx. See also N-NITROSO COMPOUNDS.
PSA: 75.76000
LogP: 0.98760
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Toxicity Data With Reference

1.   

mmo-sat 1 µg/plate

    MUREAV    Mutation Research. 68 (1979),1.
2.   

mma-sat 20 nmol/plate

    CNREA8    Cancer Research. 39 (1979),1328.
3.   

dnr-esc 1 mmol/L

    CNREA8    Cancer Research. 45 (1985),6471.
4.   

dnd-hmn:ovr 50 µmol/L

    INSSDM    INSERM Symposium. 19 (1981),33.
5.   

dnd-mus:leu 10 µmol/L

    CNREA8    Cancer Research. 43 (1983),175.
6.   

msc-ham:lng 10 µmol/L

    CNREA8    Cancer Research. 40 (1980),2719.
7.   

ipr-mus LD50:4368 µg/kg

    NCISP*    National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program, Bethesda, MD 20205 JAN86 .
8.   

ivn-mus LD10:4700 µg/kg

    ANBCB3    Antibiotics and Chemotherapy. 23 (1978),64.

Consensus Reports

EPA Genetic Toxicology Program.

Safety Profile

Poison by intraperitoneal and intravenous routes. Human mutation data reported. Many N-nitroso compounds are carcinogens. When heated to decomposition it emits very toxic fumes of Cl− and NOx. See also N-NITROSO COMPOUNDS.