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25122-57-0

Basic Information
CAS No.: 25122-57-0
Name: Pregna-1,4-diene-3,11,20-trione,21-chloro-9-fluoro-16-methyl-17-(1-oxobutoxy)-, (16b)-
Molecular Structure:
Molecular Structure of 25122-57-0 (Pregna-1,4-diene-3,11,20-trione,21-chloro-9-fluoro-16-methyl-17-(1-oxobutoxy)-, (16b)-)
Formula: C26H32ClFO5
Molecular Weight: 479.03
Synonyms: Pregna-1,4-diene-3,11,20-trione,21-chloro-9-fluoro-17-hydroxy-16b-methyl-, butyrate (8CI);Butyric acid, ester with21-chloro-9-fluoro-17-hydroxy-16b-methylpregna-1,4-diene-3,11,20-trione (8CI);CCl 5537;Clobetasone17-butyrate;Emovate;Eumovate;GR 2/1214;Kindavate;Molivate;SN 203;
EINECS: 246-635-9
Density: 1.26 g/cm3
Melting Point: 90-100°
Boiling Point: 573.3 °C at 760 mmHg
Flash Point: 181.1 °C
Solubility:
Appearance:
Hazard Symbols: HarmfulXn
Risk Codes: 40
Safety: 22-36
Transport Information:
PSA: 77.51000
LogP: 4.70140
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Chemistry

IUPAC Name : [(8S,9R,10S,13S,14S,16S,17R)-17-(2-chloroacetyl)-9-fluoro-10,13,16-trimethyl-3,11-dioxo-7,8,12,14,15,16-hexahydro-6H-cyclopenta[a]phenanthren-17-yl] butano (25122-57-0)
CAS: 25122-57-0
Synonyms: 11,20-Trione,21-chloro-9-fluoro-17-hydroxy-16-beta-methyl-pregna-4-diene-3 N ;21-Chloro-9-fluoro-17-hydroxy-16-beta-methylpregna-1,4-diene,3,11,20-trione ; Eumovate ; Molivate;Pregna-1,4-diene-3,11,20-trione,21-chloro-9-fluoro-16-methyl-17-(1-oxobutoxy ; Sn203 ; 21-chloro-9-fluoro-17-hydroxy-16beta-methylpregna-1,4-diene-3,11,20-trione 17-butyrate 
Molecular Formula  :C26H32ClFO5
Molecular Weight  :478.99
EINECS: 246-635-9
MS:
Product Categories: Organics
Mol File: 25122-57-0.mol
Surface Tension: 47 dyne/cm
Density: 1.26 g/cm
Flash Point: 181.1 °C 
Enthalpy of Vaporization: 85.92 kJ/mol 
Boiling Point: 573.3 °C at 760 mmHg 
Vapour Pressure: 3.78E-13 mmHg at 25°C 
Stability: Stable. Combustible. Incompatible with strong oxidizing agents.

Uses

1. Clobetasone butyrate (25122-57-0) is good for the treatment of congenital atopic dermatitis, face, neck, axilla, perineal eczema and other diseases.
2.Apply to affected area with ointment, 1, 1 ~ 3 times.
3. Clobetasone butyrate (25122-57-0) can cause local irritation, itching, acne, miliaria, white ringworm, etc. should be promptly disabled. 2. Large or long-term large-scale applications, there may be glucocorticoid side effects.

Toxicity Data With Reference

Organism

Test Type

Route

Reported Dose (Normalized Dose)

Effect

Source

mouse

LD50

intraperitoneal

500mg/kg (500mg/kg)

 

Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 14, Pg. 838, 1983.

mouse

LD50

oral

> 6gm/kg (6000mg/kg)

behavioral: somnolence (general depressed activity)
blood: changes in spleen
skin and appendages (skin): hair: other

Yakkyoku. Pharmacy. Vol. 35, Pg. 1473, 1984.

mouse

LD50

subcutaneous

> 3600mg/kg (3600mg/kg)

behavioral: somnolence (general depressed activity)
blood: changes in spleen
skin and appendages (skin): hair: other

Yakkyoku. Pharmacy. Vol. 35, Pg. 1473, 1984.

rat

LD50

intraperitoneal

1510mg/kg (1510mg/kg)

endocrine: other changes
blood: changes in spleen
blood: other changes

Journal of Toxicological Sciences. Vol. 5, Pg. 45, 1980.

rat

LD50

oral

> 6gm/kg (6000mg/kg)

behavioral: somnolence (general depressed activity)
blood: changes in spleen
skin and appendages (skin): hair: other

Yakkyoku. Pharmacy. Vol. 35, Pg. 1473, 1984.

rat

LD50

subcutaneous

> 2600mg/kg (2600mg/kg)

behavioral: somnolence (general depressed activity)
blood: changes in spleen
skin and appendages (skin): hair: other

Yakkyoku. Pharmacy. Vol. 35, Pg. 1473, 1984.

Safety Profile

Hazard Codes:  Xn
Risk Statements:  40
40:  Limited evidence of a carcinogenic effect 
Safety Statements:  22-36
22:  Do not breathe dust 
36: Clobetasone butyrate (25122-57-0) used,please wear suitable protective clothing .
RTECS : TU4154083