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27220-47-9

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Basic Information
CAS No.: 27220-47-9
Name: Econazole
Article Data: 3
Molecular Structure:
Molecular Structure of 27220-47-9 (Econazole)
Formula: C18H15Cl3N2O
Molecular Weight: 381.689
Synonyms: Imidazole,1-[2,4-dichloro-b-[(p-chlorobenzyl)oxy]phenethyl]-(8CI);1-[2,4-Dichloro-b-[(p-chlorobenzyl)oxy]phenethyl]imidazole;NSC 187789;
EINECS: 248-341-6
Density: 1.33 g/cm3
Melting Point: 86.8 °C
Boiling Point: 533.8 °C at 760 mmHg
Flash Point: 276.6 °C
Solubility: 0.37g/L(ambient temperature)
Hazard Symbols: IrritantXi
Risk Codes: 36/37/38
Safety: 24/25-36/37/39
PSA: 27.05000
LogP: 5.80140
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  • Econazole

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    27220-47-9

    Econazole

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  • 1H-Imidazole,1-[2-[(4-chlorophenyl)methoxy]-2-(2,4-dichlorophenyl)ethyl]-

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  • Econazole CAS No.27220-47-9

  • Casno:

    27220-47-9

    Econazole CAS No.27220-47-9

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Chemistry

Molecular Formula: C18H15Cl3N2O
Formula Weight: 381.68
mp: 86.8°C
State: Solid
Predicted WATER Solubility: 1.48e-03 mg/mL

Uses

Econazole is the first generation of products Imidazole antifungal agents. It is used topically in dermatomycoses also orally and parenterally.

Production

10.3 in the α-(2,4-dichlorophenyl)-imidazole-1-ethanol and 2.1 in Sodium hydride 50 anhydrous tetrahydrofuran the slurry mixing returning 2h, when hydrogen reaction after successive accession 60 dimethyl formamide and 8-chloro-benzyl chloride to return 2h. Tetrahydrofuran pressure steam addition, the residues dumped into the WATER with Benzene extraction, extracts from decompression Benzene, in econazole in the free base, and then concentrated nitric acid, generating econazole nitrate.

Toxicity Data With Reference

Overdosage of econazole in humans has not been reported to date. In mice, rats guinea pigs and dogs, the oral LD50 values were found to be 462, 668, 272, and > 160 mg/kg, respectively.

Safety Profile

Hazard Codes : Xi
Risk Statements : 36/37/38
Safety Statements : 24/25-36/37/39