Welcome to LookChem.com Sign In|Join Free
  • or
Home > Pharmaceutical > 2731 > 

2731-16-0

Products Categories

Basic Information
CAS No.: 2731-16-0
Name: Thiocolciran
Article Data: 17
Molecular Structure:
Molecular Structure of 2731-16-0 (Thiocolciran)
Formula: C20H23 N O4 S
Molecular Weight: 373.473
Synonyms: Benzo[a]heptalen-9(5H)-one,7-amino-6,7-dihydro-1,2,3-trimethoxy-10-(methylthio)-, (S)-; Colchicine,N-deacetyl-10-thio- (6CI,7CI,8CI); (-)-Thiodeacetylcolchicine;N-Deacetyl-10-thiocolchicine; N-Deacetylthiocolchicine;N-Desacetylthiocolchicine; NSC 9170; PKH 147; Thio-Colciran
Density: 1.27g/cm3
Melting Point: 198 °C
Boiling Point: 631.6°Cat760mmHg
Flash Point: 335.8°C
Safety: Poison by ingestion, intraperitoneal, intravenous, intramuscular, parenteral and intracerebral routes. An experimental teratogen. Human systemic effects by intravenous route: hypermotility, diarrhea, nausea, vomiting, and leukopenia (reduced white blood cell count). When heated to decomposition it emits very toxic fumes of NOx and SOx. See also COLCHICINE.
PSA: 96.08000
LogP: 4.10780
Related products
Hot Products
  • Display:default sort

    New supplier

  • Benzo[a]heptalen-9(5H)-one,7-amino-6,7-dihydro-1,2,3-trimethoxy-10-(methylthio)-, (7S)-

  • Casno:

    2731-16-0

    Benzo[a]heptalen-9(5H)-one,7-amino-6,7-dihydro-1,2,3-trimethoxy-10-(methylthio)-, (7S)-

    Min.Order: 1 Kilogram

    FOB Price:  USD $ 3.0-3.0

    As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

    Dayang Chem (Hangzhou) Co.,Ltd. dedicated to the development, production and marketing of chemicals which is specialized in Organic compounds; Active Pharmaceutical Ingredi

  •  Dayang Chem (Hangzhou) Co.,Ltd.

     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:+86-571-88938639

    Address:9/F, Unit 2 Changdi Torch Building, 259# WenSan Road, Xihu District, Hangzhou City 310012, P.R.China

       Inquiry Now

  • tianfu-chem_Thiocolciran 2731-16-0

  • Casno:

    2731-16-0

    tianfu-chem_Thiocolciran 2731-16-0

    Min.Order: 1 Kilogram

    FOB Price:  USD $ 0.0-0.0

    Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

    Our company engages in Electronic chemicals such as OLED，Photoresist chemical，Electrolyte additive and Intermediate Pharmaceutical production; development of noble metal catalysts,

  •  Henan Tianfu Chemical Co., Ltd.

     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:86-371-55170693/55170694

    Address:Zhengzhou International Trade New Territory,Jinshui District,Zhengzhou ,China

       Inquiry Now

  • Benzo[a]heptalen-9(5H)-one,7-amino-6,7-dihydro-1,2,3-trimethoxy-10-(methylthio)-, (7S)-

  • Casno:

    2731-16-0

    Benzo[a]heptalen-9(5H)-one,7-amino-6,7-dihydro-1,2,3-trimethoxy-10-(methylthio)-, (7S)-

    Min.Order: 1 Metric Ton

    FOB Price:  USD $ 1.0-1.0

    We are a Union of chemistry in China, consists of chemists，engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

    We are a Union of chemistry in China, consists of chemists，engineers, laboratories,factories in China. We organize surplus capacity of R&D and production in China for chemicals cus

  •  Bluecrystal chem-union

    China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:+86-1895157

    Address:Liang Xi Qu

       Inquiry Now

  • (7S)-7-amino-1,2,3-trimethoxy-10-methylsulfanyl-6,7-dihydro-5H-benzo[a]heptalen-9-one

  • Casno:

    2731-16-0

    (7S)-7-amino-1,2,3-trimethoxy-10-methylsulfanyl-6,7-dihydro-5H-benzo[a]heptalen-9-one

    Min.Order: 0

    FOB Price:  USD $ 0.0-0.0

    We are committed to providing our customers with the best products and services at the most competitive prices.Appearance:clear liquid Storage:Room temperature with sealed well Package:according to the clients requirement Application:Use as primary a

    BOC Sciences is a brand of BOCSCI Inc. We leverage our wide spectrum of business in the fields of development, manufacturing, marketing, and distribution to help you make best-info

  •  BOC Sciences

    United States  |  Contact Details

    Business Type:Trading Company

    Tel:1-631-485-4226

    Address:Ramsey Road

       Inquiry Now

  • Thiocolciran

  • Casno:

    2731-16-0

    Thiocolciran

    Min.Order: 0

    FOB Price:  USD $ 0.0-0.0

    factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

    Zhejiang Jiuzhou Chemical Co.,Ltd is a market-oriented and innovation-driven biopharmaceutical company. The company is focusing on the R&D, manufacturing and sales of pharmaceutica

  •  ZHEJIANG JIUZHOU CHEM CO.,LTD

    China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:+86 19334956669

    Address:Waisha Road,Jiaojiang

       Inquiry Now

  • Total:8 Page 1 of 1 1
Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 2731-16-0

Chemistry

IUPAC Name: (7S)-7-amino-1,2,3-trimethoxy-10-methylsulfanyl-6,7-dihydro-5H-benzo[a]heptalen-9-one 
Empirical Formula: C20H23NO4S
Molecular Weight: 373.4659g/mol
Index of Refraction: 1.624
Molar Refractivity: 103.46 cm3
Molar Volume: 292.7 cm
3 Polarizability: 41.01×10-24cm3
Surface Tension: 54.7 dyne/cm
Density: 1.27 g/cm3
Flash Point: 335.8 °C
Enthalpy of Vaporization: 93.4 kJ/mol
Boiling Point: 631.6 °C at 760 mmHg
Vapour Pressure: 7.33E-16 mmHg at 25°C
Canonical SMILES: COC1=C(C(=C2C(=C1)CCC(C3=CC(=O)C(=CC=C32)SC)N)OC)OC
Isomeric SMILES: COC1=C(C(=C2C(=C1)CC[C@@H](C3=CC(=O)C(=CC=C32)SC)N)OC)OC
InChI: InChI=1S/C20H23NO4S/c1-23-16-9-11-5-7-14(21)13-10-15(22)17(26-4)8-6-12(13)18(11)20(25-3)19(16)24-2/h6,8-10,14H,5,7,21H2,1-4H3/t14-/m0/s1
InChIKey: NUNCOHUMTCDISK-AWEZNQCLSA-N
Structure of N-Deacetylthiocolchicine (CAS NO.2731-16-0):

Toxicity Data With Reference

1.    

ivn-mky TDLo:6 mg/kg (13-14W preg):TER

     ACEDAB    Acta Endocrinologica, Supplementum. 166 (1972),435.
2.    

ivn-hmn TDLo:71 µg/kg/D:GIT,BLD

     BAFEAG    Bulletin de lAssociation Francaise pour lEtude du Cancer. 42 (1955),308.
3.    

ipr-rat LD50:175 mg/kg

     PSEBAA    Proceedings of the Society for Experimental Biology and Medicine. 98 (1958),479.
4.    

ims-rat LD50:37 mg/kg

     PSEBAA    Proceedings of the Society for Experimental Biology and Medicine . 98 (Academic Press,New York, NY.: )1958,479.
5.    

ice-rat LDLo:2 mg/kg

     AIPTAK    Archives Internationales de Pharmacodynamie et de Therapie. 109 (1957),386.
6.    

par-rat LDLo:2000 µg/kg

     FRPSAX    Farmaco, Edizione Scientifica. 15 (1960),533.
7.    

orl-mus LD50:50 mg/kg

     BAFEAG    Bulletin de lAssociation Francaise pour lEtude du Cancer. 42 (1955),308.
8.    

ipr-mus LD50:66 mg/kg

     JMCMAR    Journal of Medicinal Chemistry. 24 (1981),636.
9.    

ivn-mus LD50:80 mg/kg

     AIPTAK    Archives Internationales de Pharmacodynamie et de Therapie. 107 (1956),150.

Safety Profile

Poison by ingestion, intraperitoneal, intravenous, intramuscular, parenteral and intracerebral routes. An experimental teratogen. Human systemic effects by intravenous route: hypermotility, diarrhea, nausea, vomiting, and leukopenia (reduced white blood cell count). When heated to decomposition it emits very toxic fumes of NOx and SOx. See also COLCHICINE.

Specification

  N-Deacetylthiocolchicine , its cas register number is 2731-16-0. It also can be called 4-14-00-00954 (Beilstein Handbook Reference) ; BRN 2822164 ; Benzo(a)heptalen-9(5H)-one, 7-amino-6,7-dihydro-1,2,3-trimethoxy-10-(methylthio)-, (S)- ; 
 Colchicine, N-deacetyl-10-demethoxy-10-methylthio- ; Colchicine, N-deacetyl-thio- ; Corps R. 261 ; 
 Deacetylthiocolchicine ; N-Deacetyl-10-demethoxy-10-methylthiocolchicine ; N-Deacetylmethylthiocolchicine ; NSC 9170 ; R 261 ; Thiolcolciran . N-Deacetylthiocolchicine (CAS NO.2731-16-0) will cause diarrhea, nausea, vomiting, and leukopenia. When heated to decomposition it emits very toxic fumes of NOx and SOx.