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| CAS No.: | 2870-71-5 |
|---|---|
| Name: | ATROPINE METHYL BROMIDE |
| Molecular Structure: | |
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|
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| Formula: | C18H26 N O3 . Br |
| Molecular Weight: | 384.313 |
| Synonyms: | 1aH,5aH-Tropanium, 3a-hydroxy-8-methyl-, bromide, (?à)-tropate (8CI);8-Azoniabicyclo[3.2.1]octane,3-(3-hydroxy-1-oxo-2-phenylpropoxy)-8,8-dimethyl-, bromide, (3-endo)- (9CI);8-Azoniabicyclo[3.2.1]octane,3-(3-hydroxy-1-oxo-2-phenylpropoxy)-8,8-dimethyl-, bromide, endo-(?à)-; 8-Methylatropinium bromide (6CI,7CI);8-Azoniabicyclo[3.2.1]octane,3-(3-hydroxy-1-oxo-2-phenylpropoxy)-8,8-dimethyl-, bromide, endo-; Atropinemethobromide; Atropine methyl bromide; Hyoscyamine methyl bromide;Methylatropine bromide; Methylatropinium bromide; Mintussin; Mydriasin; N-Methylatropinebromide; N-Methylatropinium bromide; NSC 61810; Tropin |
| Density: | g/cm3 |
| Melting Point: | 222-223° |
| Boiling Point: | °Cat760mmHg |
| Flash Point: | °C |
| Hazard Symbols: | Xn,N |
| Risk Codes: | 22-50/53 |
| Safety: | Poison by subcutaneous, intraduodenal, intraperitoneal, and intravenous routes. Moderately toxic by ingestion. When heated to decomposition it emits very toxic fumes of NOx and Br−. See also BROMIDES. |
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Chemistry
Molecular Structure of Atropine methobromide (CAS NO.2870-71-5): .png)
Molecular Formula: C18H26NO3+
Molecular Weight : 304.40394 g/mol
Classification Code: Drug / Therapeutic Agent
IUPAC: (8,8-Dimethyl-8-azoniabicyclo[3.2.1]octan-3-yl) 3-hydroxy-2-phenylpropanoate
Synonyms: (RS)-8-Methyl-3alpha-tropoyloxy-1alphaH,5alphaH-tropaniumbromid ; 3-alpha-Hydroxy-8-methyl-1-alpha,5-alpha-H-tropanium bromide (+-)tropate ; 3alpha-Hydroxy-8-methyl-1alphaH,5alphaH-tropanium bromide ; 8-Methylatropinium bromide ; Atropine methobromide ; Atropine methylbromide ; Atropinium, 8-methyl-, bromide ; Atropinum methylobromatum
CAS: 2870-71-5
EINECS: 220-700-1
Water Solubility: 5.00E+05 mg/L
Toxicity Data With Reference
Toxicity of of Atropine methobromide (CAS NO.2870-71-5):
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| guinea pig | LD50 | intravenous | 118mg/kg (118mg/kg) | Drugs in Japan Vol. -, Pg. 1172, 1990. | |
| guinea pig | LD50 | subcutaneous | 358mg/kg (358mg/kg) | Drugs in Japan Vol. -, Pg. 1172, 1990. | |
| mouse | LD50 | intraperitoneal | 75mg/kg (75mg/kg) | SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA | Arzneimittel-Forschung. Drug Research. Vol. 21, Pg. 1727, 1971. |
| mouse | LD50 | intravenous | 9950ug/kg (9.95mg/kg) | Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 53, Pg. 1125, 1957. | |
| mouse | LD50 | oral | 1640mg/kg (1640mg/kg) | Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 53, Pg. 1125, 1957. | |
| mouse | LD50 | subcutaneous | 242mg/kg (242mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 18, Pg. 1132, 1968. | |
| rat | LD50 | intraduodenal | 312mg/kg (312mg/kg) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 180, Pg. 155, 1969. | |
| rat | LD50 | oral | 1050mg/kg (1050mg/kg) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 180, Pg. 155, 1969. | |
| rat | LD50 | subcutaneous | 1800mg/kg (1800mg/kg) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 180, Pg. 155, 1969. |
Consensus Reports
Reported in EPA TSCA Inventory.
Safety Profile
Hazard Codes of Atropine methobromide (CAS NO.2870-71-5):
Xn
N
Risk Statements: R22:Harmful if swallowed. R50/53:Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
Safety Statements:S36:Wear suitable protective clothing. S60:This material and its container must be disposed of as hazardous waste. S61:Avoid release to the environment. Refer to special instructions / safety data sheets.
RIDADR: UN 3077 9/PG 3
RTECS: YM3720000
Poison by subcutaneous, intraduodenal, intraperitoneal, and intravenous routes. Moderately toxic by ingestion. When heated to decomposition it emits very toxic fumes of NOx and Br−. See also BROMIDES.