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| CAS No.: | 299-75-2 |
|---|---|
| Name: | treosulfan |
| Molecular Structure: | |
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| Formula: | C6H14 O8 S2 |
| Molecular Weight: | 278.304 |
| Synonyms: | 1,2,3,4-Butanetetrol,1,4-dimethanesulfonate, [S-(R*,R*)]-;Threitol, 1,4-dimethanesulfonate,(2S,3S)- (8CI);(2S,3S)-Threitol 1,4-bismethanesulfonate;L-Threitol1,4-bis(methanesulfonate);NSC 39069;Ovastat;Threosulphan;Treosulfan;Treosulphan;Tresulfan; |
| EINECS: | 206-081-0 |
| Density: | 1.562g/cm3 |
| Melting Point: | 76-78 °C |
| Boiling Point: | 607°Cat760mmHg |
| Flash Point: | 320.9°C |
| Safety: | Confirmed carcinogen. Poison by intravenous route. Human mutation data reported. When heated to decomposition it emits toxic fumes of SOx. |
| PSA: | 143.96000 |
| LogP: | -0.17780 |
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Chemistry
IUPAC Name: (2,3-Dihydroxy-4-methylsulfonyloxybutyl) methanesulfonate
Synonyms: 1,2,3,4-1,2,3,4-Butanetetrol, 1,4-dimethanesulfonate ; 1,2,3,4-Butanetetrol, 1,4-dimethanesulfonate, (R*,R*)- (9CI) ; 1,2,3,4-Butanetetrol, 1,4-dimethanesulfonate, (R*,S*)- (9CI) ; 1,2,3,4-Butanetetrol, 1,4-dimethanesulfonate, (S-(R*,R*))- (9CI) ; 2,3-Dihydroxybutane-1,4-diyl dimethanesulfonate
CAS NO: 299-75-2
Molecular Formula of l-Threitol-1,4-bismethanesulfonate (CAS NO.299-75-2) :C6H14O8S2
Molecular Weight of l-Threitol-1,4-bismethanesulfonate (CAS NO.299-75-2) :278.3006
Molecular Structure of l-Threitol-1,4-bismethanesulfonate (CAS NO.299-75-2) : .jpg){kind=small}
EINECS: 206-081-0
Index of Refraction: 1.517
Surface Tension: 64.4 dyne/cm
Density: 1.562 g/cm3
Flash Point: 320.9 °C
Enthalpy of Vaporization: 103.49 kJ/mol
Boiling Point: 607 °C at 760 mmHg
Vapour Pressure: 2.86E-17 mmHg at 25°C
Appearance:Odorless white crystalline powder.
Uses
l-Threitol-1,4-bismethanesulfonate (CAS NO.299-75-2) is mainly used in the clinical treatment of ovarian cancer, but also for treatment of tumor resection after adjuvant therapy.
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| dog | LDLo | intravenous | 222mg/kg (222mg/kg) | GASTROINTESTINAL: OTHER CHANGES BLOOD: LEUKOPENIA BLOOD: OTHER CHANGES | Cancer Chemotherapy Reports, Part 2. Vol. 2, Pg. 203, 1965. |
| monkey | LDLo | intravenous | 222mg/kg (222mg/kg) | BLOOD: LEUKOPENIA BLOOD: AGRANULOCYTOSIS BLOOD: OTHER CHANGES | Cancer Chemotherapy Reports, Part 2. Vol. 2, Pg. 203, 1965. |
Consensus Reports
IARC Cancer Review: Group 1 IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 ,1987,p. 363.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Human Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 26 ,1981,p. 341.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . EPA Genetic Toxicology Program.
Safety Profile
Confirmed carcinogen. Poison by intravenous route. Human mutation data reported. When heated to decomposition it emits toxic fumes of SOx.
RIDADR 2811
HazardClass 6.1(b)
PackingGroup III
Specification
1.Air & Water Reactions :Water soluble. Slowly hydrolyzes: decomposes within 3 hours at pH 7.5 and 77°F. .
2.Fire Hazard :Flash point data for treosulfan are not available; however, treosulfan is probably combustible.