CAS No.31329-57-4,NAFRONYL Suppliers

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Basic Information

Molecular Structure:
CAS No.:	31329-57-4
Name:	NAFRONYL
Article Data:	6

Formula:	C24H33 N O3
Molecular Weight:	383.531
Synonyms:	2-Furanpropionicacid, tetrahydro-a-(1-naphthylmethyl)-,2-(diethylamino)ethyl ester (7CI,8CI);2-(Diethylamino)ethyl tetrahydro-a-(1-naphthylmethyl)-2-furanpropionateester;Gevatran;LS 84;N-Diethylamino ethyl b-(1-naphthol)-b-(2-tetrahydrofuryl)isobutyrate oxolate salt;Nafronyl;Naftidrofuryl;Naphtidrofuryl;Tridus;
EINECS:	250-572-2
Density:	1.079g/cm³
Melting Point:	80-83°C
Boiling Point:	518.3°Cat760mmHg
Flash Point:	267.3°C
Hazard Symbols:	Xi
Safety:	Poison by ingestion, subcutaneous, intraperitoneal, and intravenous routes. When heated to decomposition it emits toxic fumes of NO_x.
PSA:	38.77000
LogP:	4.45260

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Chemistry

Product Name: Naftidrofuryl (CAS NO.31329-57-4)

Molecular Formula: C₂₄H₃₃NO₃
Molecular Weight: 383.52g/mol
Mol File: 31329-57-4.mol
Einecs: 250-572-2
Boiling point: 518.3 °C at 760 mmHg
Flash Point: 267.3 °C
Density: 1.079 g/cm³
Surface Tension: 43.2 dyne/cm
Enthalpy of Vaporization: 79.08 kJ/mol
Vapour Pressure: 7.57E-11 mmHg at 25°C
XLogP3-AA: 4.8
H-Bond Donor: 0
H-Bond Acceptor: 4
Structure Descriptors of Naftidrofuryl (CAS NO.31329-57-4):
IUPAC Name: 2-diethylaminoethyl 2-(naphthalen-1-ylmethyl)-3-(oxolan-2-yl)propanoate
Canonical SMILES: CCN(CC)CCOC(=O)C(CC1CCCO1)CC2=CC=CC3=CC=CC=C32
InChI: InChI=1S/C24H33NO3/c1-3-25(4-2)14-16-28-24(26)21(18-22-12-8-15-27-22)17-20-11-7-10-19-9-5-6-13-23(19)20/h5-7,9-11,13,21-22H,3-4,8,12,14-18H2,1-2H3
InChIKey: KBAFPSLPKGSANY-UHFFFAOYSA-N

Uses

Naftidrofuryl (CAS NO.31329-57-4) (INN, also known as nafronyl or as the oxalate salt nafronyl oxalate) is a drug used in the management of peripheral and cerebral vascular disorders. It is claimed to enhance cellular oxidative capacity and to be a spasmolytic. It may also be a 5-HT₂ receptor antagonist.

Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	129mg/kg (129mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: CYANOSIS	Gendai no Rinsho. Vol. 5, Pg. 1, 1971.
mouse	LD50	intravenous	23mg/kg (23mg/kg)		European Journal of Toxicology and Environmental Hygiene. Vol. 8, Pg. 188, 1975.
mouse	LD50	oral	365mg/kg (365mg/kg)		European Journal of Medicinal Chemistry--Chimie Therapeutique. Vol. 10, Pg. 291, 1975.
mouse	LD50	subcutaneous	272mg/kg (272mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: CYANOSIS	Gendai no Rinsho. Vol. 5, Pg. 1, 1971.
rat	LD50	intraperitoneal	120mg/kg (120mg/kg)	SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) LUNGS, THORAX, OR RESPIRATION: CYANOSIS	Gendai no Rinsho. Vol. 5, Pg. 1, 1971.
rat	LD50	oral	1890mg/kg (1890mg/kg)	SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) LUNGS, THORAX, OR RESPIRATION: CYANOSIS	Gendai no Rinsho. Vol. 5, Pg. 1, 1971.
rat	LD50	subcutaneous	2500mg/kg (2500mg/kg)	SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) LUNGS, THORAX, OR RESPIRATION: CYANOSIS	Gendai no Rinsho. Vol. 5, Pg. 1, 1971.

Safety Profile

Poison by ingestion, subcutaneous, intraperitoneal, and intravenous routes. When heated to decomposition it emits toxic fumes of NO_x.

Specification

Naftidrofuryl ,its CAS NO. is 31329-57-4,the synonyms is 2-(Diethylamino)ethyl tetrahydro-alpha-(1-naphthylmethyl)-2-furanpropionate ; 3-(1-Naphthyl)-2-tetrahydrofurfurylpropionic acid 2-(diethylamino)ethyl ester ; BRN 1296059 ; EINECS 250-572-2 ; LS 84 ; N-Diethylaminoethyl beta-(1-naphthyl)-beta-tetrahydrofuryl isobutyrate ; Nafronyl ; Naftidrofurilo ; Tetrahydro-alpha-(1-naphthalenylmethyl)-2-furanpropanoic acid 2-(diethylamino)ethyl ester ; Tetrahydro-alpha-(1-naphthylmethyl)-2-furanpropanoic acid 2-(diethylamino)ethyl ester ; Tridus ; UNII-42H8PQ0NMJ ; alpha-Tetrahydrofurfuryl-1-naphthalenepropionic acid 2-(diethylamino)ethyl ester .