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| CAS No.: | 334-88-3 | |
|---|---|---|
| Name: | Diazomethane | |
| Molecular Structure: | ||
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| Formula: | CH2 N2 | |
| Molecular Weight: | 42.0403 | |
| Synonyms: | Azimethylene;Diazirine; Diazomethane; Diazonium methylide | |
| Density: | g/cm3 | |
| Melting Point: | -145° | |
| Boiling Point: | °Cat760mmHg | |
| Flash Point: | °C | |
| Appearance: | white to light yellow crystal powde | |
| Hazard Symbols: | Severe explosion risk when shocked; may explode on contact with alkali metals, rough surfaces, or heat (100C); toxic by inhalation, a carcinogen (OSHA). TLV: 0.2 ppm. | |
| Risk Codes: | 45 | |
| Safety: | Confirmed carcinogen with experimental tumorigenic data. A poisonous irritant by inhalation. A powerful allergen. It can cause pulmonary edema and frequently causes hypersensitivity leading to asthmatic symptoms. Mutation data reported. Highly explosive when shocked, exposed to heat, or by chemical reaction. Undiluted liquid or gas may explode on contact with alkali metals, rough surfaces, heat (100°C), high-intensity light, or shock. When heated to decomposition or on contact with acid or acid fumes it emits highly toxic fumes of NOx. Incompatible with alkali metals; calcium sulfate. | |
Analytical Methods: | For occupational chemical analysis use NIOSH: Diazomethane, 2515. |
|
| PSA: | 37.39000 | |
| LogP: | -0.00214 | |
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Chemistry
Empirical Formula: CH2N2
Molecular Weight: 42.04
EINECS: 206-382-7
Melting point: -145 °C
Appearance: Yellow gas with a musty odor
Structure of Diazomethane (CAS NO.334-88-3):
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IUPAC Name of Diazomethane (CAS NO.334-88-3): Diazomethane
Canonical SMILES: C=[N+]=[N-]
InChI: InChI=1S/CH2N2/c1-3-2/h1H2
InChIKey: YXHKONLOYHBTNS-UHFFFAOYSA-N
Uses
Diazomethane (CAS NO.334-88-3) is almost universally used as a solution in diethyl ether, and is also frequently used as a carbene source.
Production
Diazomethane (CAS NO.334-88-3) is prepared by hydrolysis of an etheric solution of an N-methyl nitrosamide with aqueous base.
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Toxicity Data With Reference
| 1. | mmo-nsc 250 mmol/L | HEREAY Hereditas. 35 (1949),521. |
Consensus Reports
IARC Cancer Review: Group 3 IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 (1987),p. 56.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 (1974),p. 223.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . EPA Genetic Toxicology Program. Community Right-To-Know List.
Safety Profile
Confirmed carcinogen with experimental tumorigenic data. A poisonous irritant by inhalation. A powerful allergen. It can cause pulmonary edema and frequently causes hypersensitivity leading to asthmatic symptoms. Mutation data reported. Highly explosive when shocked, exposed to heat, or by chemical reaction. Undiluted liquid or gas may explode on contact with alkali metals, rough surfaces, heat (100°C), high-intensity light, or shock. When heated to decomposition or on contact with acid or acid fumes it emits highly toxic fumes of NOx. Incompatible with alkali metals; calcium sulfate.
Hazard Codes: 
T
Risk Statements: 45
R45:May cause cancer.
Safety Statements: 53-45
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S53:Avoid exposure - obtain special instructions before use.
Standards and Recommendations
OSHA PEL: TWA 0.2 ppm
ACGIH TLV: TWA 0.2 ppm; Suspected Human Carcinogen
DFG MAK: Animal Carcinogen, Suspected Human Carcinogen
Analytical Methods
For occupational chemical analysis use NIOSH: Diazomethane, 2515.
Specification
Diazomethane ,its cas register number is 334-88-3. It also can be called Methane, diazo- ; and Azimethylene . It is one of the more common diazo compounds, and it is a popular methylating agent in the laboratory, but it is too hazardous. Diazomethane (CAS NO.334-88-3) can be treated with an excess of benzoic acid in cold Et2O. It is toxic by inhalation or by contact with the skin or eyes (TLV 0.2ppm) and explodes when heated beyond 100 °C.