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| CAS No.: | 372-48-5 |
|---|---|
| Name: | 2-Fluoropyridine |
| Molecular Structure: | |
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| Formula: | C5H4FN |
| Molecular Weight: | 97.0919 |
| Synonyms: | Pyridine, 2-fluoro-;5-20-05-00397 (Beilstein Handbook Reference);2-Fluoro-pyridine; |
| EINECS: | 206-757-5 |
| Density: | 1.118 g/cm3 |
| Boiling Point: | 125.929 °C at 760 mmHg |
| Flash Point: | 28.333 °C |
| Solubility: | Soluble in water. |
| Appearance: | clear colourless to light yellow liquid |
| Hazard Symbols: |
 Xi,  F,  Xn
|
| Risk Codes: | 10-36/37/38-20/21/22 |
| Safety: | 26-36-36/37/39-16 |
| Transport Information: | UN 1993 3/PG 3 |
| PSA: | 12.89000 |
| LogP: | 1.22070 |
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Specification
The IUPAC name of this chemical is 2-fluoropyridine. With the CAS registry number 372-48-5, it is also named as Pyridine, 2-fluoro-. The product's categories are Fluorin-contained Pyridine Series; Pyridine; Pyridine Derivative; Pyridines; Fluoropyridines; Halopyridines; C5; Heterocyclic Building Blocks. It is clear colourless to light yellow liquid.
The other characteristics of 2-Fluoropyridine can be summarized as: (1)ACD/LogP: 1.08; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 1.081; (4)ACD/LogD (pH 7.4): 1.081; (5)ACD/BCF (pH 5.5): 3.906; (6)ACD/BCF (pH 7.4): 3.906; (7)ACD/KOC (pH 5.5): 92.289; (8)ACD/KOC (pH 7.4): 92.289; (9)#H bond acceptors: 1; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 0; (12)Index of Refraction: 1.472; (13)Molar Refractivity: 24.338 cm3; (14)Molar Volume: 86.867 cm3; (15)Polarizability: 9.648×10-24 cm3; (16)Surface Tension: 33.22 dyne/cm; (17)Enthalpy of Vaporization: 34.874 kJ/mol; (18)Vapour Pressure: 14.441 mmHg at 25°C; (19)Exact Mass: 97.032777; (20)MonoIsotopic Mass: 97.032777; (21)Topological Polar Surface Area: 12.9; (22)Heavy Atom Count: 7; (23)Complexity: 56.
Preparation of 2-Fluoropyridine: It can be obtained by pyridin-2-ylamine. This reaction needs reagents pentyl nitrite and hydrofluoric acid.
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Uses of 2-Fluoropyridine: It is used as intermediate of pharmaceutical and pesticide. It also can react with thiophene to get 2-thiophen-2-yl-pyridine. This reaction needs reagent nBuLi and solvent diethyl ether.
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When you are using this chemical, please be cautious about it as the following:
It is flammable, so people should keep it away from sources of ignition. Besides, it is not only harmful by inhalation, in contact with skin and if swallowed, but also irritating to eyes, respiratory system and skin. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. If you want to contact this product, you must wear suitable protective clothing, gloves and eye/face protection.
People can use the following data to convert to the molecule structure.
1. SMILES:c1ccnc(c1)F
2. InChI:InChI=1/C5H4FN/c6-5-3-1-2-4-7-5/h1-4H
3. InChIKey:MTAODLNXWYIKSO-UHFFFAOYAS