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| CAS No.: | 3810-80-8 |
|---|---|
| Name: | DIPHENOXYLATE HYDROCHLORIDE |
| Molecular Structure: | |
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| Formula: | C30H32 N2 O2 . Cl H |
| Molecular Weight: | 489.10 |
| Synonyms: | 4-Piperidinecarboxylicacid, 1-(3-cyano-3,3-diphenylpropyl)-4-phenyl-, ethyl ester, monohydrochloride(9CI); Isonipecotic acid, 1-(3-cyano-3,3-diphenylpropyl)-4-phenyl-, ethylester, hydrochloride (6CI,7CI); Isonipecotic acid,1-(3-cyano-3,3-diphenylpropyl)-4-phenyl-, ethyl ester, monohydrochloride (8CI);1-(3-Cyano-3,3-diphenylpropyl)-4-phenylpiperidine-4-carboxylic acid ethyl esterhydrochloride; 2,2-Diphenyl-4-(4-carbethoxy-4-phenyl-1-piperidino)butyronitrilehydrochloride; 2,2-Diphenyl-4-(4-carboxy-4-phenyl-1-piperidino)butyronitrileethyl ester hydrochloride; Diphenoxylate hydrochloride; R 1132; R 1132(antiperistaltic) |
| Density: | g/cm3 |
| Melting Point: | 220.5-222° |
| Boiling Point: | 602.3°Cat760mmHg |
| Flash Point: | 318°C |
| Safety: | A poison by ingestion. When heated to decomposition it emits very toxic fumes of HCl and NOx. |
| PSA: | 53.33000 |
| LogP: | 6.22318 |
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This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.
Chemistry
Molecular Structure of Lomotil (CAS NO.3810-80-8):
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IUPAC Name: ethyl 1-(3-cyano-3,3-diphenylpropyl)-4-phenylpiperidin-1-ium-4-carboxylate chloride
Empirical Formula: C30H33ClN2O2
Molecular Weight: 489.0482
Flash Point: 318 °C Enthalpy of Vaporization: 89.61 kJ/mol
Boiling Point: 602.3 °C at 760 mmHg Vapour Pressure: 1.84E-14 mmHg at 25°C
Classification Code : Antiperistaltic ; Drug / Therapeutic Agent
Synonyms of Lomotil (CAS NO.3810-80-8): 1-(3-Cyano-3,3-diphenylpropyl)-4-phenyl-4-piperidinecarboxylic Acid Ethyl Ester Monohydrochloride ; 1-(3-cyano-3,3-diphénylpropyl)-4-phénylpipéridine-4-carboxylate d'éthyle chlorhydrate ; 4-piperidinecarboxylic acid, 1-(3-cyano-3,3-diphenylpropyl)-4-phenyl-, ethyl ester, hydrochloride (1:1) ; Diphenoxylate hydrochloride (USP) ; ethyl 1-(3-cyano-3,3-diphenylpropyl)-4-phenylpiperidine-4-carboxylate hydrochloride ; ethyl 1-(3-cyano-3,3-diphenylpropyl)-4-phenylpiperidine-4-carboxylate hydrochloride (1:1) ; Ethyl-1-(3-cyan-3,3-diphenylpropyl)-4-phenylpiperidin-4-carboxylathydrochlorid ; 4-Ethoxycarbonyl-alpha,alpha,4-triphenyl-1-piperidinebutyronitrile, hydrochloride
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intraperitoneal | > 320mg/kg (320mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 24, Pg. 1636, 1974. | |
| mouse | LD50 | subcutaneous | > 160mg/kg (160mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 24, Pg. 1636, 1974. | |
| rat | LD50 | oral | 221mg/kg (221mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 24, Pg. 1633, 1974. |
Safety Profile
A poison by ingestion. When heated to decomposition it emits very toxic fumes of HCl and NOx.
Specification
Lomotil (CAS NO.3810-80-8) is a toxic material,burning will produce toxic nitrogen oxide gases.Besides should be stored and transported in low-temperature,drying environment. separately with oxidizing agents.Fire extinguishing agents water, carbon dioxide, dry powder, foam would be used if emergency.