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| CAS No.: | 444731-52-6 |
|---|---|
| Name: | Pazopanib |
| Article Data: | 7 |
| Molecular Structure: | |
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| Formula: | C21H23N7O2S |
| Molecular Weight: | 437.525 |
| Synonyms: | 5-[[4-[(2,3-Dimethyl-2H-indazol-6-yl)(methyl)amino]pyrimidin-2-yl]amino]-2-methylbenzenesulfonamide;GW 786034;Benzenesulfonamide,5-[[4-[(2,3-dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methyl-;Votrient; |
| Density: | 1.40 g/cm3 |
| Melting Point: | 285-289°C (dec.) |
| Boiling Point: | 728.814 °C at 760 mmHg |
| Flash Point: | 394.572 °C |
| Appearance: | White powder |
| Risk Codes: | 43-62/63 |
| Safety: | 36/37/39-28B |
| PSA: | 127.41000 |
| LogP: | 4.99310 |
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Specification
Pazopanib, its cas register number 444731-52-6. It also can be called GW786034; 5-[[4-[(2,3-Dimethyl-2H-indazol-6-yl)(methyl)amino]pyrimidin-2-yl]amino]-2-methylbenzenesulfonamide; Pazopanib; UNII-7RN5DR86CK. Its classification code is Antineoplastic Agents. It belongs to the Intermediates & Fine Chemicals; Pharmaceuticals; HFC80010. Pazopanib is a potent and selective multi-targeted receptor tyrosine kinase inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFR-α/β, and c-Kit. And it is used as an oral angiogenesis inhibitor targeting VEGFR and PDGFR.
Physical properties about Pazopanib are: (1)ACD/LogP: 3.117; (2)ACD/LogD (pH 5.5): 2.48; (3)ACD/LogD (pH 7.4): 3.10; (4)ACD/BCF (pH 5.5): 32.07; (5)ACD/BCF (pH 7.4): 131.95; (6)ACD/KOC (pH 5.5): 275.29; (7)ACD/KOC (pH 7.4): 1132.61; (8)#H bond acceptors: 9; (9)#H bond donors: 3; (10)#Freely Rotating Bonds: 4; (11)Index of Refraction: 1.702; (12)Molar Refractivity: 120.188 cm3; (13)Molar Volume: 310.355 cm3; (14)Polarizability: 47.646 10-24cm3; (15)Surface Tension: 56.6650009155273 dyne/cm; (16)Density: 1.41 g/cm3; (17)Flash Point: 394.572 °C; (18)Enthalpy of Vaporization: 106.395 kJ/mol; (19)Boiling Point: 728.814 °C at 760 mmHg;
You can still convert the following datas into molecular structure:
(1)InChI=1S/C21H23N7O2S/c1-13-5-6-15(11-19(13)31(22,29)30)24-21-23-10-9-20(25-21)27(3)16-7-8-17-14(2)28(4)26-18(17)12-16/h5-12H,1-4H3,(H2,22,29,30)(H,23,24,25);
(2)InChIKey=CUIHSIWYWATEQL-UHFFFAOYSA-N;
(3)SmilesCc1ccc(cc1S(=O)(=O)N)Nc2nccc(n2)N(C)c3ccc4c(n(nc4c3)C)C