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| CAS No.: | 461-78-9 |
|---|---|
| Name: | chlorоphentermine |
| Molecular Structure: | |
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| Formula: | C10H14 Cl N |
| Molecular Weight: | 183.681 |
| Synonyms: | Phenethylamine,p-chloro-a,a-dimethyl- (6CI,8CI);1-(4-Chlorophenyl)-2-methylpropan-2-amine;1-(p-Chlorophenyl)-2-methyl-2-aminopropane;4-Chloro-a,a-dimethylphenethylamine;Chlorphentermine;Clorfentermina;Desopimon;Effox;Lucofen SA;Teramine;p-Chloro-a,a-dimethylphenethylamine;a,a-Dimethyl-4-chlorobenzeneethanamine; |
| EINECS: | 207-314-9 |
| Density: | 1.074g/cm3 |
| Boiling Point: | 255.8°Cat760mmHg |
| Flash Point: | 127°C |
| Safety: | Poison by ingestion, intraperitoneal, subcutaneous, and intravenous routes. Human systemic effects by ingestion: blood pressure elevation and sympathetic nervous system stimulation. An experimental teratogen. Mutation data reported. An anorectic drug which diminishes the appetite. When heated to decomposition it emits very toxic fumes of Cl− and NOx. |
| PSA: | 26.02000 |
| LogP: | 3.32010 |
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Chemistry
IUPAC Name: 1-(4-Chlorophenyl)-2-methylpropan-2-amine
Synonyms of Chlorphentermine (CAS NO.461-78-9) : 1-(4-Chlorophenyl)-2-methylpropan-2-amine ; 4-Chloro-a,a-dimethylbenzeneethanamine ; a,a-Dimethyl-p-chlorophenethylamine ; Avicol ; Benzeneethanamine, 4-chloro-.alpha.,.alpha.-dimethyl-
CAS NO: 461-78-9
Molecular Formula:C10H14ClN
Molecular Weight :183.6779
Molecular Structure :
EINECS: 207-314-9
Index of Refraction: 1.537
Surface Tension: 37.6 dyne/cm
Density: 1.074 g/cm3
Flash Point: 127 °C
Enthalpy of Vaporization: 49.33 kJ/mol
Boiling Point: 255.8 °C at 760 mmHg
Vapour Pressure: 0.016 mmHg at 25°C
History
Chlorphentermine (CAS NO.461-78-9) is developed in 1962, it is the 4-chloro derivative of the better known appetite suppressant phentermine,which is still in current use.Chlorphentermine itself is a relatively weak stimulant with little abuse potential, but is classed as a Schedule 3 drug in the USA due mainly to its similarity to other appetite suppressants such as diethylpropion which have been more widely abused. It is no longer used due mainly to safety concerns, as it has a serotonergic effects profile similar to other withdrawn appetite suppressants such as fenfluramine and aminorex which were found to cause pulmonary hypertension and cardiac fibrosis following prolonged use.
Uses
Chlorphentermine (CAS NO.461-78-9) (trade names Apsedon, Desopimon, Lucofen) is an appetite suppressant.
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| man | TDLo | oral | 5357ug/kg (5.357mg/kg) | AUTONOMIC NERVOUS SYSTEM: SYMPATHOMIMETIC VASCULAR: BP ELEVATION NOT CHARACTERIZED IN AUTONOMIC SECTION | Therapie. Vol. 34, Pg. 205, 1979. |
| mouse | LD50 | intraperitoneal | 150mg/kg (150mg/kg) | Acta Pharmaceutica Suecica. Vol. 15, Pg. 87, 1978. | |
| mouse | LD50 | intravenous | 56mg/kg (56mg/kg) | U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#00697, | |
| mouse | LD50 | oral | 270mg/kg (270mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION BEHAVIORAL: EXCITEMENT | Acta Poloniae Pharmaceutica Vol. 26, Pg. 598, 1969. |
| mouse | LD50 | subcutaneous | 260mg/kg (260mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: EXCITEMENT LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION | Acta Poloniae Pharmaceutica Vol. 26, Pg. 598, 1969. |
| rat | LD50 | oral | 250mg/kg (250mg/kg) | Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 65(6), Pg. 218S, 1969. |
Safety Profile
Poison by ingestion, intraperitoneal, subcutaneous, and intravenous routes. Human systemic effects by ingestion: blood pressure elevation and sympathetic nervous system stimulation. An experimental teratogen. Mutation data reported. An anorectic drug which diminishes the appetite. When heated to decomposition it emits very toxic fumes of Cl− and NOx.