CAS No.481-49-2,Cepharanthine Suppliers

Products Categories

Pharmaceutical (65)
Plant Extract (43)
Organic Chemicals (18)
Others (16)
Reagent (6)
(1)

Basic Information

Molecular Structure:
CAS No.:	481-49-2
Name:	Cepharanthine
Article Data:	4

Formula:	C₃₇H₃₈N₂O₆
Molecular Weight:	606.719
Synonyms:	Cepharanthine(6CI,7CI,8CI);Oxyacanthan,6',12'-dimethoxy-2,2'-dimethyl-6,7-[methylenebis(oxy)]-;(+)-Cepharanthine;1H-4,6:16,19-Dietheno-21,25-metheno-12H-[1,3]dioxolo[4,5-g]pyrido[2',3':17,18][1,10]dioxacycloeicosino[2,3,4-ij]isoquinoline,2,3,13,14,14a,15,26,26a-octahydro-22,30-dimethoxy-1,14-dimethyl-,[14aS-(14aR,26aS)]-;Cepharantin;NSC 623442;O-Methylcepharanoline;
Density:	1.227 g/cm³
Melting Point:	140 - 145oC
Boiling Point:	654.03°C (rough estimate)
Appearance:	Yellow powder.
PSA:	61.86000
LogP:	6.74970

Country:
Business Type:
All

Lab/Research institutions

Trading Company

Manufacturers

Other
Certificate:
Manufacturer

Enterprise Authentication

ISO

GMP

FDA

HALAL

Display:default sort
Suppiers of more reward points first

New supplier

Total:103 Page 1 of 3 1 2 3 Next>>

Post a RFQ

Cas No.:

Product Name:

Quantity:

Email:

Company name:

Valid Period:

Detailed Requirements:

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

What can I do for you?
Get Best Price

Get Best Price for 481-49-2

Specification

The Cepharanthine, with the CAS registry number 481-49-2, has the systematic name 6',12'-Dimethoxy-2,2'-dimethyl-6,7-(methylenebis(oxy))oxyacanthan. Its product categories are Herbs; Alkaloidsand and its classification codes are Analgesics; Analgesics, Non-Narcotic; Anti-Inflammatory Agents; Anti-inflammatory agents, non-steroidal; Antineoplastic Agents; Antineoplastic agents, phytogenic; Antirheumatic Agents; Drug / Therapeutic Agent; Peripheral Nervous System Agents; Protective Agents; Radiation-Protective Agents; Reproductive Effect; Sensory System Agents. For it's soluble in acidic aqueous solution and ethyl ether, acetone and other organic solvents, insoluble in petroleum ether, keep it tightly sealed in cool and dry place with light brown glass bottles and avoid it contact with oxides. Moreover, it could be made from the stephania powder.

Other characteristics of the Cepharanthine can be summarised as followings: (1)ACD/LogP: 5.23; (2)# of Rule of 5 Violations: 2; (3)ACD/LogD (pH 5.5): 1.59; (4)ACD/LogD (pH 7.4): 4.57; (5)ACD/BCF (pH 5.5): 1.26; (6)ACD/BCF (pH 7.4): 1216.3; (7)ACD/KOC (pH 5.5): 3.79; (8)ACD/KOC (pH 7.4): 3652.59; (9)#H bond acceptors: 8; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 2; (12)Polar Surface Area: 61.86 Å²; (13)Index of Refraction: 1.608; (14)Molar Refractivity: 170.93 cm³; (15)Molar Volume: 494.2 cm³; (16)Polarizability: 67.76×10^-24cm³; (17)Surface Tension: 45 dyne/cm; (18)Density: 1.227 g/cm³.

Uses of the Cepharanthine: It's an isoquinoline alkaloid from tubers of stephania and it has stimulates recovery of immunologic function in lymphatic system after administration of antineoplastic agents or x-irradiation. Popular chemicals glycerol is also made from this chemical.

You can still convert the following datas into molecular structure:
1.SMILES: O4c1c(OC)cc2c(c1)[C@H](N(C)CC2)Cc8ccc(OC)c(Oc3ccc(cc3)C[C@H]7c6c4c5OCOc5cc6CCN7C)c8
2.InChI: InChI=1/C37H38N2O6/c1-38-13-11-24-18-31(41-4)33-20-27(24)28(38)16-23-7-10-30(40-3)32(17-23)44-26-8-5-22(6-9-26)15-29-35-25(12-14-39(29)2)19-34-36(37(35)45-33)43-21-42-34/h5-10,17-20,28-29H,11-16,21H2,1-4H3/t28-,29+/m1/s1
3.InChIKey: YVPXVXANRNDGTA-WDYNHAJCBM

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	125mg/kg (125mg/kg)		Chemical and Pharmaceutical Bulletin. Vol. 24, Pg. 2413, 1976.
mouse	LD50	intravenous	43500ug/kg (43.5mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: CHRONIC PULMONARY EDEMA	Kiso to Rinsho. Clinical Report. Vol. 16, Pg. 3855, 1982.
mouse	LD50	oral	1900mg/kg (1900mg/kg)	SKIN AND APPENDAGES (SKIN): HAIR: OTHER	Kiso to Rinsho. Clinical Report. Vol. 16, Pg. 3855, 1982.
mouse	LD50	subcutaneous	100mg/kg (100mg/kg)		Kiso to Rinsho. Clinical Report. Vol. 16, Pg. 3855, 1982.
rat	LD50	intraperitoneal	> 155mg/kg (155mg/kg)		Drugs in Japan Vol. -, Pg. 648, 1995.
rat	LD50	intravenous	57mg/kg (57mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Kiso to Rinsho. Clinical Report. Vol. 16, Pg. 3855, 1982.
rat	LD50	oral	2gm/kg (2000mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: CHRONIC PULMONARY EDEMA	Kiso to Rinsho. Clinical Report. Vol. 16, Pg. 3855, 1982.
rat	LD50	subcutaneous	100mg/kg (100mg/kg)		Kiso to Rinsho. Clinical Report. Vol. 16, Pg. 3855, 1982.