Products Categories
| CAS No.: | 486-12-4 |
|---|---|
| Name: | Triprolidine |
| Molecular Structure: | |
|
|
|
| Formula: | C19H22N2 |
| Molecular Weight: | 278.397 |
| Synonyms: | Pyridine,2-[(1E)-1-(4-methylphenyl)-3-(1-pyrrolidinyl)-1-propenyl]- (9CI);Pyridine,2-[1-(4-methylphenyl)-3-(1-pyrrolidinyl)-1-propenyl]-, (E)-;Pyridine,2-[3-(1-pyrrolidinyl)-1-p-tolylpropenyl]-, (E)- (8CI);Triprolidin;Triprolidine;Tripyrolidine;trans-1-(2-Pyridyl)-3-pyrrolidino-1-p-tolylprop-1-ene;trans-1-(4-Methylphenyl)-1-(2-pyridyl)-3-pyrrolidinoprop-1-ene;trans-2-[3-(1-Pyrrolidinyl)-1-p-tolypropenyl]pyridine; |
| EINECS: | 207-627-0 |
| Density: | 1.061 g/cm3 |
| Melting Point: | 59-61 °C |
| Boiling Point: | 435.4 °C at 760 mmHg |
| Flash Point: | 217.1 °C |
| Solubility: | insoluble in water |
| Appearance: | crystals |
| PSA: | 16.13000 |
| LogP: | 3.85540 |
- 5156-58-1N-(1-Benzyl-4-pipperidinyl)-N-phenylpropanamide HCl
- 81281-59-67-Benzylideneaminotheophylline
- 50288-62-5threo-Phenyl-2-piperidyl acetamide
- 82993-81-5D-threo-Ritalinic acid hydrochloride
- 73441-42-6METHYL-5-CHLORO-2,2-DIMETHYLVALERATE
- 68439-39-4Poly(oxy-1,2-ethanediyl), alpha-(2-ethylhexyl)-omega-hydroxy-,
- 852475-26-4MC1568
- 958254-66-51H-Imidazo[4,5-b]pyridine-2-carboxaldehyde, 1-methyl-, hydrochloride
- 99170-93-1N-Methyl-2-oxazolamine
- 717878-06-31-(4-fluorophenyl)-4-nitro-1H-imidazole
- Total:34 Page 1 of 1 1
What can I do for you?
Get Best Price
Specification
The Triprolidine, with the CAS registry number 486-12-4, is also known as Pyridine, 2-[(1Z)-1-(4-methylphenyl)-3-(1-pyrrolidinyl)-1-propen-1-yl]-. Its EINECS registry number is 207-627-0. This chemical's molecular formula is C19H22N2 and molecular weight is 278.39. Its IUPAC name is called 2-[(E)-1-(4-methylphenyl)-3-pyrrolidin-1-ylprop-1-enyl]pyridine. This chemical's classification codes are Anti-allergic agents; Drug / Therapeutic Agent; Histamine Agents; Histamine Antagonists; Histamine H1 antagonists; Human Data; Neurotransmitter Agents. Triprolidine is used to combat the symptoms associated with allergies and is sometimes combined with other cold medications designed to provide general relief for flu-like symptoms. What' more, it is a quick acting drug that can clear congestion and stop runny noses in 15-30 minutes. It is crystals.
Physical properties of Triprolidine: (1)ACD/LogP: 4.22; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 1.26; (4)ACD/LogD (pH 7.4): 2.72; (5)ACD/BCF (pH 5.5): 1.03; (6)ACD/BCF (pH 7.4): 29.87; (7)ACD/KOC (pH 5.5): 5.11; (8)ACD/KOC (pH 7.4): 147.98; (9)#H bond acceptors: 2; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 4; (12)Index of Refraction: 1.587; (13)Molar Refractivity: 88.12 cm3; (14)Molar Volume: 262.1 cm3; (15)Surface Tension: 43.2 dyne/cm; (16)Density: 1.061 g/cm3; (17)Flash Point: 217.1 °C; (18)Enthalpy of Vaporization: 69.17 kJ/mol; (19)Boiling Point: 435.4 °C at 760 mmHg; (20)Vapour Pressure: 8.8E-08 mmHg at 25°C.
You can still convert the following datas into molecular structure:
(1)Canonical SMILES: CC1=CC=C(C=C1)C(=CCN2CCCC2)C3=CC=CC=N3
(2)Isomeric SMILES: CC1=CC=C(C=C1)/C(=C\CN2CCCC2)/C3=CC=CC=N3
(3)InChI: InChI=1S/C19H22N2/c1-16-7-9-17(10-8-16)18(19-6-2-3-12-20-19)11-15-21-13-4-5-14-21/h2-3,6-12H,4-5,13-15H2,1H3/b18-11+
(4)InChIKey: CBEQULMOCCWAQT-WOJGMQOQSA-N
The toxicity data is as follows:
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| human | TDLo | oral | 143ug/kg (0.143mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ALTERATION OF OPERANT CONDITIONING BEHAVIORAL: CHANGES IN PSYCHOPHYSIOLOGICAL TESTS | European Journal of Clinical Pharmacology. Vol. 47, Pg. 331, 1994. |