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| CAS No.: | 508-77-0 |
|---|---|
| Name: | CYMARIN |
| Molecular Structure: | |
|
|
|
| Formula: | C30H44 O9 |
| Molecular Weight: | 548.674 |
| Synonyms: | Cymarin(6CI,7CI,8CI);Alvonal MR;Cymarine;K-Strophanthin-a;NSC 7522;Strophantin K;WV 90043a; |
| EINECS: | 208-087-9 |
| Density: | 1.31 g/cm3 |
| Melting Point: | 148ºC |
| Boiling Point: | 722.1ºCat 760 mmHg |
| Flash Point: | 232.7 ºC |
| Hazard Symbols: |
 T
|
| Risk Codes: | 23/25-33 |
| Safety: | Poison by intravenous, intraperitoneal, and possibly other routes. Used as a cardiotonic. When heated to decomposition it emits acrid smoke and fumes. |
| PSA: | 131.75000 |
| LogP: | 2.43330 |
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Chemistry
Product Name: Cymarin (CAS NO.508-77-0)
Molecular Formula: C30H44O9
Molecular Weight: 548.66g/mol
Mol File: 508-77-0.mol
Einecs: 208-087-9
Boiling point: 722.1 °C at 760 mmHg
Storage Temperature: 2-8°C
Flash Point: 232.7 °C
Density: 1.31 g/cm3
Surface Tension: 59.4 dyne/cm
Enthalpy of Vaporization: 120.47 kJ/mol
Vapour Pressure: 4.46E-24 mmHg at 25°C
XLogP3: 0.8
H-Bond Donor: 3
H-Bond Acceptor: 9
Product Categories: Cardioglycosides & Glycosides; Carbohydrates; Carbohydrates A to; Carbohydrates P-ZBiochemicals and Reagents; Polysaccharide
Uses
Cymarin (CAS NO.508-77-0) is a cardiogenic toxin that causes cardiac arrhythmia in humans. Cymarin is used in modern medicine in copiously formulated pharmaceutical preparations used to treat a variety of tumors.
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| cat | LD50 | intravenous | 95ug/kg (0.095mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 74, Pg. 223, 1942. | |
| cat | LD50 | parenteral | 110ug/kg (0.11mg/kg) | Bollettino Chimico Farmaceutico. Vol. 98, Pg. 297, 1959. | |
| cat | LDLo | unreported | 110ug/kg (0.11mg/kg) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 148, Pg. 471, 1964. | |
| mouse | LD50 | intracrebral | 41ug/kg (0.041mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 908, 1961. |
| mouse | LD50 | intraperitoneal | 12mg/kg (12mg/kg) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 155, Pg. 165, 1965. | |
| mouse | LD50 | intravenous | 2800ug/kg (2.8mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 908, 1961. |
| rat | LD50 | intravenous | 20mg/kg (20mg/kg) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 155, Pg. 165, 1965. |
Safety Profile
Poison by intravenous, intraperitoneal, and possibly other routes. Used as a cardiotonic. When heated to decomposition it emits acrid smoke and fumes.
Safety Information of Cymarin (CAS NO.508-77-0):
Hazard Codes: T.gif){kind=small}
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Risk Statements: 23/25-33-26/27/28
23: Toxic by inhalation
25: Toxic if swallowed
26: Very Toxic by inhalation
27: Very Toxic in contact with skin
28: Very Toxic if swallowed
33: Danger of cumulative effects
Safety Statements: 45-36/37/39
36: Wear suitable protective clothing
37: Wear suitable gloves
39: Wear eye/face protection
45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
Specification
Cymarin ,its CAS NO. is 508-77-0,the synonyms is 20(22),5Beta-cardenolid-19-al-3beta,5beta,14beta-triol 3beta-mixed glycosides ; Cimarin ; Cymarine ; k Strophanthin ; k-Strophanthin-a ; k-Strophanthin-alpha ; k-Strophanthidin-d-cymaroside .