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52-85-7

Basic Information
CAS No.: 52-85-7
Name: FAMPHUR
Molecular Structure:
Molecular Structure of 52-85-7 (FAMPHUR)
Formula: C10H16NO5PS2
Molecular Weight: 325.346
Synonyms: Phosphorothioicacid, O,O-dimethyl ester, O-ester with p-hydroxy-N,N-dimethylbenzenesulfonamide(8CI);Phosphorothioic acid, O-[p-(dimethylsulfamoyl)phenyl] O,O-dimethyl ester(6CI);Benzenesulfonamide, p-hydroxy-N,N-dimethyl-, O-ester with O,O-dimethylphosphorothioate;CL 38023;ENT 25,644;Famfur;Famophos;Famphos;Famphur;O,O-DimethylO-[p-(dimethylsulfamoyl)phenyl] phosphorothioate;O,O-Dimethyl phosphorothioateO-ester with p-hydroxy-N,N-dimethylbenzenesulfonamide;Warbex;
EINECS: 200-154-0
Density: 1.354 g/cm3
Melting Point: -96.7 ºC
Boiling Point: 394.2 ºC at 760 mmHg
Flash Point: 192.2 ºC
Solubility: Moderate; 50-99%
Appearance: LIQUID
Hazard Symbols: ToxicT
Risk Codes: 63-43-36/37/38-23/24/25-45
Safety: 22-24/25-45-36/37-23-53
PSA: 115.35000
LogP: 3.56440
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Consensus Reports

Reported in EPA TSCA Inventory.

Specification

    Famphur with the CAS registry number 52-85-7, is also named as American cyanamid CL 38023 ; O-[4-(Dimethylsulfamoyl)phenyl] O,O-dimethyl phosphorothioate ; Phosphorothioic acid,O,O-dimethyl ester O-ester with p-hydroxy-N,N-dimethylbenzenesulfonamide .
   Organothiophosphates, such as Famphur, are susceptible to formation of highly toxic and flammable phosphine gas in the presence of strong reducing agents such as hydrides. Partial oxidation by oxidizing agents may result in the release of toxic phosphorus oxides. Famphur (CAS NO.52-85-7) is used as insecticide.
   Poison by ingestion and intramuscular routes. Moderately toxic by skin contact. A cholinesterase inhibitor. When heated to decomposition it emits toxic fumes of NOx and SOx. See also parathion. 1.It is possible risk of harm to the unborn child, so people don't breathe dust. 2. It is may cause sensitization by skin contact and irritating to eyes, respiratory system and skin., people must be avoid contact with skin and eyes and wear suitable protective clothing and gloves. 3. It is toxic by inhalation, in contact with skin and if swallowed, so people do not breathe vapour. 4. It is may cause cancer,  so it is must avoid exposure and obtain special instructions before use. And  Its toxic tabulation is:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
bird - wild LD50 oral 1800ug/kg (1.8mg/kg)   Toxicology and Applied Pharmacology. Vol. 21, Pg. 315, 1972.
domestic animals - goat/sheep LD50 intramuscular 59mg/kg (59mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: FOOD INTAKE (ANIMAL)
Veterinariya. Veterinary Science. Vol. 54(12), Pg. 94, 1978.
domestic animals - goat/sheep LD50 oral 400mg/kg (400mg/kg)   "Organophosphorus Pesticides: Organic and Biological Chemistry," Eto, M., Cleveland, OH, CRC Press, Inc., 1974Vol. -, Pg. 299, 1974.
mammal (species unspecified) LD50 intramuscular 64mg/kg (64mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: FOOD INTAKE (ANIMAL)

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)
Veterinariya. Veterinary Science. Vol. 54(12), Pg. 94, 1978.
mouse LD50 intraperitoneal 11600ug/kg (11.6mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Journal of Agricultural and Food Chemistry. Vol. 13, Pg. 366, 1965.
mouse LD50 oral 9500ug/kg (9.5mg/kg)   Agricultural and Biological Chemistry. Vol. 34, Pg. 1697, 1970.
rabbit LD50 skin 1460mg/kg (1460mg/kg)   World Review of Pest Control. Vol. 9, Pg. 119, 1970.
rat LD50 oral 28mg/kg (28mg/kg)   Fundamental and Applied Toxicology. Vol. 7, Pg. 299, 1986.
rat LD50 skin 400mg/kg (400mg/kg)   Fundamental and Applied Toxicology. Vol. 7, Pg. 299, 1986.