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| CAS No.: | 521-78-8 |
|---|---|
| Name: | TRIMIPRAMINE MALEATE SALT |
| Molecular Structure: | |
|
|
|
| Formula: | C20H26N2•C4H4O4 |
| Molecular Weight: | 410.56 |
| Synonyms: | trimipraminehydrogenmaleate |
| Density: | 1.029g/cm3 |
| Melting Point: | 141-143°C |
| Boiling Point: | 411.8°Cat760mmHg |
| Flash Point: | 183.3°C |
| Hazard Symbols: | Xn,T,F |
| Risk Codes: | 22-36/37/38-63-36/38-23/25-39/23/24/25-23/24/25-11 |
| Safety: | Poison by subcutaneous, intravenous, and intraperitoneal routes. Moderately toxic by ingestion. An experimental teratogen. When heated to decomposition it emits toxic fumes of NOx. |
| PSA: | 81.08000 |
| LogP: | 3.89780 |
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Chemistry
IUPAC Name: But-2-enedioic acid; 3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N,2-trimethyl-propan-1-amine
Synonyms: 3-(10,11-Dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N,2-trimethylpropan-1-amine (2Z)-but-2-enedioate (1:1) ; 5H-Dibenz[b,f]azepine-5-propanamine, 10,11-dihydro-N,N,beta-trimethyl-, (2Z)-2-butenedioate (1:1) ; 10,11-Dihydro-N,N,beta-trimethyl-5H-dibenz(b,f)azepine-5-propanamine (Z)-2-butenedioate (1:1)
Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals;Biogenic Amine Transport Inhibitors;Biogenic Amine Transport InhibitorsObesity Research;Neurotransmission;Neurotransmission (Obesity);Neurotransmitters
CAS NO: 521-78-8
Molecular Formula of Surmontil maleate (CAS NO.521-78-8) :C24H30N2O4
Molecular Weight of Surmontil maleate (CAS NO.521-78-8) : 410.51
Molecular Structure of Surmontil maleate (CAS NO.521-78-8) : 
EINECS: 208-318-3
Flash Point: 183.3 °C
Enthalpy of Vaporization: 66.43 kJ/mol
Boiling Point: 411.8 °C at 760 mmHg
Vapour Pressure: 5.45E-07 mmHg at 25°C
Melting point: 141-143°C
Storage temp: 2-8°C
Appearance:White Crystalline Solid
Uses
Antidepressant; serotonin transport blocker that also blocks norepinephrine uptake
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intramuscular | 223mg/kg (223mg/kg) | Drugs in Japan Vol. -, Pg. 876, 1995. | |
| mouse | LD50 | intraperitoneal | 140mg/kg (140mg/kg) | Farmaco, Edizione Pratica. Vol. 25, Pg. 519, 1970. | |
| mouse | LD50 | intravenous | 40mg/kg (40mg/kg) | Farmaco, Edizione Pratica. Vol. 25, Pg. 519, 1970. | |
| mouse | LD50 | oral | 425mg/kg (425mg/kg) | Drugs in Japan Vol. 6, Pg. 526, 1982. | |
| mouse | LD50 | subcutaneous | 240mg/kg (240mg/kg) | Farmaco, Edizione Pratica. Vol. 25, Pg. 519, 1970. | |
| rabbit | LD50 | intravenous | 27mg/kg (27mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | British Journal of Pharmacology and Chemotherapy. Vol. 25, Pg. 158, 1965. |
| rat | LD50 | intraperitoneal | 150mg/kg (150mg/kg) | Farmaco, Edizione Pratica. Vol. 25, Pg. 519, 1970. | |
| rat | LD50 | intravenous | 38mg/kg (38mg/kg) | Farmaco, Edizione Pratica. Vol. 25, Pg. 519, 1970. | |
| rat | LD50 | oral | 800mg/kg (800mg/kg) | Farmaco, Edizione Pratica. Vol. 25, Pg. 519, 1970. | |
| rat | LD50 | subcutaneous | 308mg/kg (308mg/kg) | Farmaco, Edizione Pratica. Vol. 25, Pg. 519, 1970 |
Safety Profile
Poison by subcutaneous, intravenous, and intraperitoneal routes. Moderately toxic by ingestion. An experimental teratogen. When heated to decomposition it emits toxic fumes of NOx.
Hazard Codes 
Xn,
T,
F
Risk Statements 22-36/37/38-63-23/25
R22:Harmful if swallowed.
R23/25:Toxic by inhalation and if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin.
R63:Possible risk of harm to the unborn child.
Safety Statements 26-36-45-33-24-16-7
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S33:Take precautionary measures against static discharges.
S24:Avoid contact with skin.
S16:Keep away from sources of ignition.
S7:Keep container tightly closed.
RIDADR 3249
WGK Germany 3
RTECS HN9260000
HazardClass 6.1(b)
PackingGroup III