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| CAS No.: | 53-79-2 |
|---|---|
| Name: | PUROMYCIN |
| Molecular Structure: | |
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| Formula: | C22H29 N7 O5 |
| Molecular Weight: | 471.516 |
| Synonyms: | Adenosine,3'-(a-amino-p-methoxyhydrocinnamamido)-3'-deoxy-N,N-dimethyl-,L- (8CI); Adenosine,3'-[[2-amino-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3'-deoxy-N,N-dimethyl-,(S)-; 1-MM; 3123L; 3'-(a-Amino-p-methoxyhydrocinnamamido)-3'-deoxy-N,N-dimethyladenosine;6-Dimethylamino-9-[3-deoxy-3-(p-methoxy-L-phenylalanylamino)-b-D-ribofuranosyl]-b-purine; Achromycin; Achromycin(purine derivative); CL 13900; P 638; Puromycin; Stillomycin; Stylomycin; b-D-Ribofuranoside,6-(dimethylamino)-9H-purine-9 3-deoxy-3-[(4-methoxy-L-phenylalanyl)amino]- |
| Density: | 1.51 g/cm3 |
| Melting Point: | 175.5-177° |
| Boiling Point: | °Cat760mmHg |
| Flash Point: | °C |
| Solubility: | Soluble in water (50 mg/ml at 20°C). |
| Hazard Symbols: | Toxic to living cells of all kinds. |
| Safety: | Poison by ingestion, intravenous, and intraperitoneal routes. An experimental teratogen. Experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits toxic fumes of NOx. An antibiotic. |
| PSA: | 160.88000 |
| LogP: | 0.29750 |
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- 717878-06-31-(4-fluorophenyl)-4-nitro-1H-imidazole
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- 548773-13-32-amino-4,6-dimethylpyrimidine-5-carboxylic acid
- Total:30 Page 1 of 1 1
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Chemistry
IUPAC Name: (2S)-2-amino-N-[(2S,3S,4R,5R)-5-[6-(dimethylamino)purin-9-yl]-4-hydroxy-2-(hydroxymethyl)oxolan-3-
yl]-3-(4-methoxyphenyl)propanamide
Molecular Weight: 471.50956 g/mol
Molecular Formula: C22H29N7O5
Density: 1.51 g/cm3
Molar Volume: 311.7 cm3
Polarizability: 47.79*10-24 cm3
Surface Tension: 61.1 dyne/cm
H-Bond Donor: 4
H-Bond Acceptor: 10
Rotatable Bond Count: 8
Tautomer Count: 2
Exact Mass: 471.223017
MonoIsotopic Mass: 471.223017
Topological Polar Surface Area: 161
Heavy Atom Count: 34
Complexity: 680
Defined Atom StereoCenter Count: 5
Canonical SMILES: CN(C)C1=NC=NC2=C1N=CN2C3C(C(C(O3)CO)NC(=O)C(CC4=CC=C(C=C4)OC)N)O
Isomeric SMILES: CN(C)C1=NC=NC2=C1N=CN2[C@H]3[C@@H]([C@@H]([C@H](O3)CO)NC(=O)[C@H](CC4=CC=C(C=C4)OC)N)O
InChI: InChI=1S/C22H29N7O5/c1-28(2)19-17-20(25-10-24-19)29(11-26-17)22-18(31)16(15(9-30)34-22)27-21(32)14(23)8-12-4-6-13(33-3)7-5-12/h4-7,10-11,14-16,18,22,30-31H,8-9,23H2,1-3H3,(H,27,32)/t14-,15+,16+,18+,22+/m0/s1
InChIKey: RXWNCPJZOCPEPQ-NVWDDTSBSA-N
Toxicity Data With Reference
| 1. | dnr-esc 100 µg/disc | CNREA8 Cancer Research. 34 (1974),1658. | ||
| 2. | cyt-dmg:oth 100 mg/L | CLDFAT Cell Differentiation. 2 (1973),97. | ||
| 3. | dni-oin:oth 100 mg/L | IJEBA6 Indian Journal of Experimental Biology. 16 (1978),1027. | ||
| 4. | dni-mus:lym 100 µmol/L | PLMEAA Planta Medica. 34 (1978),231. | ||
| 5. | dni-mus:fbr 420 µmol/L | JCLBA3 Journal of Cell Biology. 58 (1973),410. | ||
| 6. | orl-mus LD50:20 mg/kg | 85GDA2 CRC Handbook of Antibiotic Compounds. 5 (1981),302. | ||
| 7. | ipr-mus LD50:25 mg/kg | 85GDA2 CRC Handbook of Antibiotic Compounds. 5 (1981),302. | ||
| 8. | ivn-mus LD50:15 mg/kg | 85GDA2 CRC Handbook of Antibiotic Compounds. 5 (1981),302. |
Safety Profile
Poison by ingestion, intravenous, and intraperitoneal routes. An experimental teratogen. Experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits toxic fumes of NOx. An antibiotic.
RIDADR: 3249
HazardClass: 6.1(b)
PackingGroup: III
Specification
Achromycin (CAS NO.53-79-2) is also called (s)-3'-((2-Amino-3-(4-methoxyphenyl)-1-oxopropyl)amino)-3'-deoxy-n,n-dimethy;1-mm ; 3'-(Alpha-amino-p-methoxyhydrocinnamamido)-3'-deoxy-n,n-dimethyl-adenosinl ; 3'-(l-Alpha-amino-p-methoxyhydrocinnamamido)-3'-deoxy-n,n-dimethyladenosine ; 6-Dimethylamino-9-(3'-(p-methoxy-l-phenylalanylamino)-beta-d-ribofuranosyl)- ; ; Achromycin(purinederivative) . Achromycin (CAS NO.53-79-2) is high toxic. It is flammable by fire. It will produce toxic nitrogen oxide fumes when buring. So the storage environment should be ventilate, low-temperature and dry. Keep Achromycin (CAS NO.53-79-2) separate from oxidants and food additives .