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| CAS No.: | 53558-25-1 |
|---|---|
| Name: | VACOR |
| Article Data: | 9 |
| Molecular Structure: | |
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| Formula: | C13H12 N4 O3 |
| Molecular Weight: | 272.263 |
| Synonyms: | 1-(4-Nitrophenyl)-3-(3-pyridylmethyl)urea;DLP 787;N-3-Pyridylmethyl-N'-p-nitrophenylurea;Pyriminil;Pyriminyl;Pyrinuron;RH 787;Vacor; |
| EINECS: | 258-626-7 |
| Density: | 1.381 g/cm3 |
| Melting Point: | 223-225oC (decomp) |
| Boiling Point: | 473.7 °C at 760 mmHg |
| Flash Point: | 240.3 °C |
| Safety: | Human poison by ingestion. Human systemic effects: altered sleep time, blood pressure lowering, change in motor activity, diabetes mellitus, distorted perceptions, dyspnea, hallucinations, hyperglycemia, somnolence, structural change in nerve or sheath. When heated to decomposition it emits toxic fumes of NOx. |
| PSA: | 99.84000 |
| LogP: | 3.29860 |
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This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.
Chemistry
IUPAC Name: 1-(4-Nitrophenyl)-3-(pyridin-3-ylmethyl)urea
The MF of Pyriminyl (CAS NO.53558-25-1) is C13H12N4O3.
The MW of Pyriminyl (CAS NO.53558-25-1) is 272.26.
Synonyms of Pyriminyl (CAS NO.53558-25-1): 1-(4-Nitrophenyl)-3-(3-pyridinylmethyl)harnstoff ; Pyriminil ; Pyrinuron
Apperance: Yellow, resembling corn meal
Index of Refraction: 1.665
Density: 1.381 g/ml
Flash Point: 240.3 °C
Boiling Point: 473.7 °C
Melting Point: 223～225 °C
EINECS: 258-626-7
Uses
Pyriminyl (CAS NO.53558-25-1) is highly toxic, available rodenticides which is not anti-clotting agent, but interfere the metabolism of nicotinamide to make nerve palsy and lung disorder and died.
Production
3-Amino methyl pyridine derived from cyanide and hydrogen with 3-methyl-pyridine as raw materials;Nitro phenyl isocyanate will generate from p-nitroaniline Phosgenation.3-Amino methyl pyridine and Nitro phenyl isocyanate will get 1-(4-Nitrophenyl)-3-(pyridin-3-ylmethyl)urea.
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| cat | LD50 | unreported | > 500mg/kg (500mg/kg) | Farm Chemicals Handbook. Vol. -, Pg. C319, 1991. | |
| chicken | LD50 | oral | 760mg/kg (760mg/kg) | PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) | Indian Journal of Pharmacology. Vol. 20, Pg. 216, 1988. |
| dog | LD50 | oral | 700mg/kg (700mg/kg) | Shokubutsu Boeki. Vol. 32, Pg. 530, 1978. | |
| man | LDLo | oral | 22286ug/kg (22.286mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" ENDOCRINE: HYPERGLYCEMIA | New England Journal of Medicine. Vol. 302, Pg. 73, 1980. |
| man | TDLo | oral | 22mg/kg (22mg/kg) | PERIPHERAL NERVE AND SENSATION: STRUCTURAL CHANGE IN NERVE OR SHEATH KIDNEY, URETER, AND BLADDER: OTHER CHANGES ENDOCRINE: DIABETES MELLITIS | Clinical Toxicology. Vol. 18, Pg. 441, 1981. |
| mouse | LD50 | oral | 56500ug/kg (56.5mg/kg) | PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) SENSE ORGANS AND SPECIAL SENSES: HEMORRHAGE: EYE | Eisei Dobutsu. Sanitary Zoology. Vol. 28, Pg. 349, 1977. |
| mouse | LD50 | unreported | 17200ug/kg (17.2mg/kg) | Zhonghua Yufangyixue Zazhi. Chinese Journal of Preventive Medicine. Vol. 13, Pg. 220, 1979. | |
| rat | LD50 | oral | 6200ug/kg (6.2mg/kg) | BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Journal of Hygiene. Vol. 80, Pg. 401, 1978. |
| rat | LD50 | unreported | 12800ug/kg (12.8mg/kg) | Zhonghua Yufangyixue Zazhi. Chinese Journal of Preventive Medicine. Vol. 13, Pg. 220, 1979. | |
| women | TDLo | oral | 31mg/kg (31mg/kg) | BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION ENDOCRINE: DIABETES MELLITIS | Clinical Toxicology. Vol. 18, Pg. 441, 1981. |
Consensus Reports
EPA Extremely Hazardous Substances List. Reported in EPA TSCA Inventory.
Safety Profile
Human poison by ingestion. Human systemic effects: altered sleep time, blood pressure lowering, change in motor activity, diabetes mellitus, distorted perceptions, dyspnea, hallucinations, hyperglycemia, somnolence, structural change in nerve or sheath. When heated to decomposition it emits toxic fumes of NOx.Safety information of Pyriminyl (CAS NO.53558-25-1):
RIDADR 2588
HazardClass 6.1(a)
PackingGroup I