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| CAS No.: | 54749-90-5 |
|---|---|
| Name: | Chlorozotocin |
| Molecular Structure: | |
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| Formula: | C9H16 Cl N3 O7 |
| Molecular Weight: | 313.73 |
| Synonyms: | CHLZ;Chlorozotocin; Chlorozotocine; DCNU; NCI 178248; NSC 178248 |
| Density: | 1.858g/cm3 |
| Melting Point: | 147-148° (dec with the evolution of gas); mp 140-141° (dec) |
| Boiling Point: | 119.3°C (rough estimate) |
| Safety: | Confirmed carcinogen with experimental carcinogenic and tumorigenic data. Poison by subcutaneous, intravenous, and intraperitoneal routes. Human systemic effects by intravenous route: anorexia, leukopenia, nausea or vomiting, thrombocytopenia. Mutation data reported. When heated to decomposition it emits very toxic fumes of Cl− and NOx. See also NITROSAMINES. |
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Chemistry
IUPAC Name: 1-(2-Chloroethyl)-1-nitroso-3-[(2R,3R,4S,5R)-3,4,5,6-tetrahydroxy-1-oxohexan-2-yl]urea
Synonyms of Chlorozotocin (CAS NO.54749-90-5) : 1-(2-Chloroethyl)-1-nitroso-3-(D-glucos-2-yl)urea ; 2-({[(2-Chloroethyl)(nitroso)amino]carbonyl}amino)-2-deoxy-alpha-D-glucopyranose ; DCNU
CAS NO: 54749-90-5
Molecular Formula:C9H16ClN3O7
Molecular Weight :313.6922
Molecular Structure :.png)
Index of Refraction: 1.664
Surface Tension: 78.6 dyne/cm
Density: 1.85 g/cm3
Uses
Chlorozotocin (CAS NO.54749-90-5) is a nitrosourea used for cancer therapy.
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| dog | LDLo | oral | 3mg/kg (3mg/kg) | GASTROINTESTINAL: CHANGE IN STRUCTURE OR FUNCTION OF ESOPHAGUS KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" BLOOD: "CHANGES IN SERUM COMPOSITION (E.G., TP, BILIRUBIN, CHOLESTEROL)" | Toxicology. Vol. 12, Pg. 31, 1979. |
| human | TDLo | intravenous | 2027ug/kg/5D (2.027mg/kg) | BLOOD: LEUKOPENIA BLOOD: THROMBOCYTOPENIA BLOOD: CHANGES IN BONE MARROW NOT INCLUDED ABOVE | Cancer Treatment Reports. Vol. 63, Pg. 17, 1979. |
| man | TDLo | intravenous | 500mg/kg (500mg/kg) | BEHAVIORAL: ANOREXIA (HUMAN GASTROINTESTINAL: NAUSEA OR VOMITING BLOOD: THROMBOCYTOPENIA | Cancer Vol. 46, Pg. 2365, 1980. |
| monkey | LDLo | oral | 400mg/kg (400mg/kg) | BEHAVIORAL: FOOD INTAKE (ANIMAL) GASTROINTESTINAL: NAUSEA OR VOMITING | Toxicology. Vol. 12, Pg. 31, 1979. |
| mouse | LD50 | intraperitoneal | 35mg/kg (35mg/kg) | INSERM Symposium. Vol. 19, Pg. 123, 1981. | |
| mouse | LD50 | intravenous | 24900ug/kg (24.9mg/kg) | KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" BLOOD: CHANGES IN SPLEEN | Toxicology. Vol. 12, Pg. 31, 1979. |
| mouse | LD50 | subcutaneous | 66230ug/kg (66.23mg/kg) | National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. Vol. JAN1986, | |
| rat | LD50 | intraperitoneal | 28mg/kg (28mg/kg) | LUNGS, THORAX, OR RESPIRATION: "FIBROSIS, FOCAL (PNEUMOCONIOSIS)" LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA GASTROINTESTINAL: OTHER CHANGES | Cancer Letters Vol. 8, Pg. 133, 1979. |
| rat | LD50 | intravenous | 22500ug/kg (22.5mg/kg) | LUNGS, THORAX, OR RESPIRATION: CHRONIC PULMONARY EDEMA BLOOD: CHANGES IN BONE MARROW NOT INCLUDED ABOVE GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH | Oncology. Vol. 37, Pg. 177, 1980. |
| rat | LDLo | subcutaneous | 40mg/kg (40mg/kg) | Toxicology and Applied Pharmacology. Vol. 82, Pg. 540, 1986. |
Consensus Reports
NTP 10th Report on Carcinogens. IARC Cancer Review: Group 2A IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 50 , 1990,p. 65.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 50 , 1990,p. 65.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 50 , 1990,p. 65.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . EPA Genetic Toxicology Program.
Safety Profile
Confirmed carcinogen with experimental carcinogenic and tumorigenic data. Poison by subcutaneous, intravenous, and intraperitoneal routes. Human systemic effects by intravenous route: anorexia, leukopenia, nausea or vomiting, thrombocytopenia. Mutation data reported. When Chlorozotocin (CAS NO.54749-90-5) is heated to decomposition, it emits very toxic fumes of Cl− and NOx. See also NITROSAMINES.