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| CAS No.: | 55-52-7 |
|---|---|
| Name: | ALPHA-BROMOISOBUTYRIC ACID |
| Article Data: | 17 |
| Molecular Structure: | |
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| Formula: | C9H14 N2 |
| Molecular Weight: | 150.224 |
| Synonyms: | Hydrazine,(a-methylphenethyl)- (6CI,8CI);(1-Methyl-2-phenylethyl)hydrazine; (a-Methylphenethyl)hydrazine; (b-Phenylisopropyl)hydrazine;1-Phenyl-2-hydrazinopropane; 2-Hydrazino-1-phenylpropane; Catron; Dicatron;PIH; Pheniprazine; Phenizine |
| Density: | 0.99g/cm3 |
| Melting Point: | 25°C |
| Boiling Point: | 287.1°Cat760mmHg |
| Flash Point: | 148°C |
| Safety: | Poison by ingestion, intraperitoneal, subcutaneous, and intravenous routes. Human systemic effects by an unspecified route: visual field effects. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx. |
| PSA: | 38.05000 |
| LogP: | 2.17210 |
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Chemistry
Product Name: Pheniprazine
CAS Registry Number: 55-52-7
Synonyms: (alpha-Methylphenethyl)hydrazine ; 1-Phenyl-2-hydrazinopropane ; 2-Hydrazino-1-phenylpropane ; 2-Hydrazinopropylbenzene ; Catron ; Dicatron ; EINECS 200-236-6 ; Fenilisopropilidrazina ; Feniprazina ; Feniprazina [INN-Spanish] ; Feniprazyne ; Feniprazyne [Polish] ; P 1142 ; PIH ; Pheniprazine ; Pheniprazinum ; Pheniprazinum [INN-Latin] ; Phenizine ; UNII-37VKD7067M ; beta-Phenylisopropylhydrazine ; Hydrazine, (1-methyl-2-phenylethyl)- (9CI)
Hydrazine, (alpha-methylphenethyl)-
IUPAC Name: 1-phenylpropan-2-ylhydrazine
Molecular Weight: 150.22086 [g/mol]
Molecular Formula: C9H14N2
XLogP3: 1.3
H-Bond Donor: 2
H-Bond Acceptor: 2
Surface Tension: 38.6 dyne/cm
Density: 0.99 g/cm3
Flash Point: 148 °C
Enthalpy of Vaporization: 52.63 kJ/mol
Boiling Point: 287.1 °C at 760 mmHg
Vapour Pressure: 0.00253 mmHg at 25°C
Following is the molecular structure of Pheniprazine (CAS NO.55-52-7) is:
Uses
Pheniprazine (CAS NO.55-52-7) was used as an antidepressant in the 1960s and it also used in the treatment of angina pectoris and schizophrenia. It has been largely discontinued due to toxicity concerns such as jaundice, amblyopia, and optic neuritis.
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| cat | LDLo | intravenous | 30mg/kg (30mg/kg) | SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS GASTROINTESTINAL: NAUSEA OR VOMITING | Journal of Pharmacology and Experimental Therapeutics. Vol. 128, Pg. 7, 1960. |
| cat | LDLo | subcutaneous | 30mg/kg (30mg/kg) | SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS GASTROINTESTINAL: NAUSEA OR VOMITING | Journal of Pharmacology and Experimental Therapeutics. Vol. 128, Pg. 7, 1960. |
| man | TDLo | unreported | 117mg/kg/2.5Y (117mg/kg) | SENSE ORGANS AND SPECIAL SENSES: VISUAL FIELD CHANGES: EYE SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE | British Medical Journal. Vol. 1, Pg. 331, 1963. |
| mouse | LD50 | intraperitoneal | 48mg/kg (48mg/kg) | BEHAVIORAL: ANTICONVULSANT | Japanese Journal of Pharmacology. Vol. 13, Pg. 186, 1963. |
| mouse | LD50 | intravenous | 12100ug/kg (12.1mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 12, Pg. 352, 1962. | |
| mouse | LD50 | oral | 121mg/kg (121mg/kg) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 166, Pg. 449, 1967. | |
| mouse | LD50 | subcutaneous | 95mg/kg (95mg/kg) | Annals of the New York Academy of Sciences. Vol. 80, Pg. 568, 1959. | |
| rat | LD50 | intraperitoneal | 40mg/kg (40mg/kg) | "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 353, 1972. | |
| rat | LD50 | intravenous | 44mg/kg (44mg/kg) | "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 353, 1972. | |
| rat | LD50 | oral | 34mg/kg (34mg/kg) | "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 353, 1972. | |
| rat | LD50 | subcutaneous | 45mg/kg (45mg/kg) | "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 353, 1972. |
Safety Profile
Poison by ingestion, intraperitoneal, subcutaneous, and intravenous routes. Human systemic effects by an unspecified route: visual field effects. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.
Specification
Pheniprazine (CAS NO.55-52-7) is an irreversible and nonselective monoamine oxidase inhibitor (MAOI) of the hydrazine chemical class.