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| CAS No.: | 55-97-0 |
|---|---|
| Name: | HEXAMETHONIUM BROMIDE |
| Article Data: | 7 |
| Molecular Structure: | |
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| Formula: | C12H30Br2N2 |
| Molecular Weight: | 362.192 |
| Synonyms: | 1,6-Hexanediaminium,N,N,N,N',N',N'-hexamethyl-, dibromide (9CI);Ammonium, hexamethylenebis[trimethyl-,dibromide (8CI);Hexamethylenebis[trimethylammonium bromide] (6CI);1,6-Bis(trimethylammonium)hexane dibromide;1,6-Hexanebis(trimethylammonium)dibromide;Bistrium bromide;C 6;Esametina;Gangliostat;Hexamethoniumbromide;Hexamethonium dibromide;Hexamethylenebis(trimethylammonium)dibromide;Hexameton;Hexameton bromide;Hexanium bromide;Hexonium dibromide;Methobromin;Methobromine;N,N,N,N',N',N'-Hexamethyl(hexamethylene)diammoniumbromide;Simpatoblock;Vegolysen;Vegolysin; |
| EINECS: | 200-249-7 |
| Melting Point: | -285 ºC |
| Appearance: | white crystalline powder and agglomerates |
| Safety: | A poison by intraperitoneal, subcutaneous, and intravenous routes. Moderately toxic by ingestion. Human reproductive and teratogenic effects by subcutaneous route: abnormal neonatal measurements and developmental abnormalities of the gastrointestinal system. Used to treat hypertension. When heated to decomposition it emits very toxic NH3, NOx, and Br−. |
| PSA: | 0.00000 |
| LogP: | -4.03280 |
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Specification
With CAS Registry Number 55-97-0, Hexamethonium bromide is also can be called Ammonium, hexamethylenebis(trimethyl-, dibromide ; Bistrium bromide ; Bromure d'hexamethonium ; Bromuro de hexametonio ; Hexamethylenebis(trimethylammonium) bromide ; Hexameton ; Hexonium dibromide . Its IUPAC Name is trimethyl-[6-(trimethylazaniumyl)hexyl]azanium dibromide . Hexamethonium bromide belongs to the following product categories: Ammonium Bromides (Quaternary); Quaternary Ammonium Compounds. And it is white crystalline powder and agglomerates.
Uses of Hexamethonium bromide: This product is a kind of nicotinic cholinergic antagonist which often referred to as the prototypical ganglionic blocker. It is poorly absorbed from the gastrointestinal tract and does not cross the blood-brain barrier.In addition, Hexamethonium bromide has been used for a variety of therapeutic purposes including hypertension but, like the other ganglionic blockers, it has been replaced by more specific drugs for most purposes, although it is widely used a research tool. Moreover, the decrease in cardiac output relative to Hexamethonium bromide in blood pressure suggests that the blood pressure reduction was largely due to the decrease in cardiac output. There was a decrease in coronary flow accompanied by an increase in myocardial oxygen extraction of such degrees that cardiac oxygen consumption remained unchanged. Since myocardial oxygen consumption remained unchanged despite the decrease in cardiac work the calculated cardiac efficiency was decreased.
When you are using this chemical, please be cautious about it as the following: Firstly, Hexamethonium bromide is irritating not only to eyes, respiratory system but also is irritating to skin. When using it, please wear suitable protective clothing, gloves and eye/face protection. It also poison by intraperitoneal, subcutaneous, and intravenous routes, and when heated to decomposition it emits very toxic NH3, NOx, and Br-. Human reproductive and teratogenic effects by subcutaneous route: abnormal neonatal measurements and developmental abnormalities of the gastrointestinal system.
The toxicity of Hexamethonium bromide as follows:
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intraperitoneal | 70mg/kg (70mg/kg) | Yakugaku Zasshi. Journal of Pharmacy. Vol. 91, Pg. 1307, 1971. | |
| mouse | LD50 | intravenous | 22mg/kg (22mg/kg) | Biochemical Pharmacology. Vol. 2, Pg. 233, 1959. | |
| mouse | LD50 | oral | 838mg/kg (838mg/kg) | Drugs in Japan Vol. 6, Pg. 356, 1982. | |
| mouse | LD50 | subcutaneous | 78mg/kg (78mg/kg) | Yakugaku Zasshi. Journal of Pharmacy. Vol. 91, Pg. 1307, 1971. | |
| rabbit | LD50 | intravenous | 50300ug/kg (50.3mg/kg) | Shionogi Kenkyusho Nenpo. Annual Report of Shionogi Research Laboratory. Vol. 10, Pg. 15, 1960. | |
| rat | LD50 | intravenous | 64130ug/kg (64.13mg/kg) | Shionogi Kenkyusho Nenpo. Annual Report of Shionogi Research Laboratory. Vol. 10, Pg. 15, 1960. | |
| rat | LD50 | oral | 2891mg/kg (2891mg/kg) | Shionogi Kenkyusho Nenpo. Annual Report of Shionogi Research Laboratory. Vol. 10, Pg. 15, 1960. | |
| rat | LD50 | subcutaneous | 200mg/kg (200mg/kg) | Proceedings of the Society for Experimental Biology and Medicine. Vol. 78, Pg. 708, 1951. |