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| CAS No.: | 57-64-7 |
|---|---|
| Name: | PHYSOSTIGMINE SALICYLATE |
| Molecular Structure: | |
|
|
|
| Formula: | C15H21N3O2•C7H6O3 |
| Molecular Weight: | 413.473 |
| Synonyms: | Eserinesalicylatesalt;Physostigminesalicylate |
| EINECS: | 200-343-8 |
| Density: | g/cm3 |
| Melting Point: | 181-183 °C |
| Boiling Point: | 393.5 °C at 760 mmHg |
| Flash Point: | 191.8 °C |
| Solubility: | Sparingly soluble in water; soluble in ethanol (~750 g/l) TS; slightly soluble in ether R. |
| Appearance: | Colourless crystals; odourless. |
| Hazard Symbols: |
 T+
|
| Risk Codes: | 26/28 |
| Safety: | 25-45 |
| Transport Information: | UN 1544 6 |
| PSA: | 102.34000 |
| LogP: | 3.25810 |
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Chemistry
IUPAC Name: [(3aR,8bS)-3,4,8b-Trimethyl-2,3a-dihydro-1H-pyrrolo[2,3-b]indol-7-yl] N-methylcarbamate ; 2-Hydroxybenzoic acid
Synonyms : Physostigmine salicylate ; Physostigmine salicylate salt ; 2-Hydroxy-,compd.with (3as-cis)-1,2,3,3a,8,8a-hexahydro-1,3a,8-benzoicaci ; Ar-44 ; Physostigmine,[salicylate(1:1)] ; Physostigmine,salicylate(1:1) ; Physostolsalicylate ; Salicylicacid,compd.with physostigmine(1:1)
Product Categories: Alkaloids;Biochemistry;Indole Alkaloids
CAS NO: 57-64-7
Molecular Formula: C22H27N3O5
Molecular Weight: 413.47
Molecular Structure: 
EINECS: 200-343-8
Mol File: 57-64-7.mol
Merck : 7384
Flash Point: 191.8 °C
Enthalpy of Vaporization: 64.34 kJ/mol
Boiling Point: 393.5 °C at 760 mmHg
Melting point: 181-183 °C
Vapour Pressure: 2.12E-06 mmHg at 25°C
Form: Physostigmine salicylate (1:1) (CAS NO.57-64-7) is solid .
Uses
Physostigmine salicylate (1:1) (CAS NO.57-64-7) is used as bulk pharmaceuticals (parasympathomimetic, cholinergic, ophthalmic, anti-Alzheimer).
Toxicity Data With Reference
| 1. | ivn-man TDLo:14 µg/kg:CVS,GIT | JCLPDE Journal of Clinical Psychiatry. 46 (1985),446. | ||
| 2. | scu-rat LD50:2 mg/kg | TXAPA9 Toxicology and Applied Pharmacology. 25 (1973),569. | ||
| 3. | ims-rat LD50:1280 µg/kg | DCTODJ Drug and Chemical Toxicology. 7 (1984),507. | ||
| 4. | orl-mus LD50:2500 µg/kg | AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. 81 (1950),726. | ||
| 5. | ipr-mus LD50:640 µg/kg | TXAPA9 Toxicology and Applied Pharmacology. 28 (1974),227. | ||
| 6. | scu-mus LD50:800 µg/kg | JPPMAB Journal of Pharmacy and Pharmacology. 34 (1982),603. | ||
| 7. | ivn-mus LD50:310 µg/kg | TXAPA9 Toxicology and Applied Pharmacology. 20 (1971),474. | ||
| 8. | scu-dog LDLo:1200 µg/kg | NTIS** National Technical Information Service. (Springfield, VA 22161) (Formerly U.S. Clearinghouse for Scientific and Technical Information) PB158-508 . | ||
| 9. | scu-cat LDLo:800 µg/kg | NTIS** National Technical Information Service. (Springfield, VA 22161) (Formerly U.S. Clearinghouse for Scientific and Technical Information) PB158-508 . | ||
| 10. | scu |
Consensus Reports
EPA Extremely Hazardous Substances List. Reported in EPA TSCA Inventory.
Safety Profile
Poison by ingestion, subcutaneous, intramuscular, intravenous, and intraperitoneal routes. Human systemic effects: arrhythmias, nausea or vomiting. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx. See also PHYSOSTIGMINE.
Hazard Codes
T+
Risk Statements 26/28
R26/28:Very toxic by inhalation and if swallowed.
Safety Statements 25-45
S25:Avoid contact with eyes.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR UN 1544 6.1/PG 1
WGK Germany 3
RTECS TJ2450000
HazardClass 6.1(a)
PackingGroup II
Specification
1.General Description: Crystal form that turns red on exposure to heat or light.
2.Reactivity Profile: Behaves as a weak acid in solution.
3.Health Hazard : Physostigmine salicylate (1:1) (CAS NO.57-64-7) is similar to physostigmine. It is classified as super toxic. The probable oral lethal dose (humans) is less than 5 mg/kg or a taste for a 150 lb. person. It is a cholinesterase inhibitor.
4.Fire Hazard: When heated to decomposition, Physostigmine salicylate (1:1) (CAS NO.57-64-7) emits toxic fumes of nitrogen oxides.