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5853-29-2

Basic Information
CAS No.: 5853-29-2
Name: cephaeline hydrochloride
Molecular Structure:
Molecular Structure of 5853-29-2 (cephaeline hydrochloride)
Formula: C28H38N2O4•2ClH
Molecular Weight: 539.60
Synonyms: 10,11,7'-trimethoxy-emet-1'-ene-9,6'-diol;cephaeline dihydrochloride;10,11,7'-Trimethoxy-emetan-6'-ol,Hydrochlorid;10,11,7'-trimethoxy-emetan-6'-ol,dihydrochloride;Alangicine;10,11,7'-Trimethoxy-emetan-6'-ol,Dihydrochlorid;
Density: 1.31g/cm3
Boiling Point: 753.4°C at 760 mmHg
Flash Point: 409.5°C
Safety: Poison by ingestion and intraperitoneal routes. When heated to decomposition it emits toxic fumes of NOx and HCl.
PSA: 63.19000
LogP: 5.70910
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Chemistry

IUPAC Name: (1R)-1-[[(3R)-3-Ethyl-9,10-dimethoxy-1,2,3,4,5,6,7,11b-octahydropyrido[2,1-a]isoquinolin-5-ium-2-yl]methyl]-7-methoxy-1,2,3,4-tetrahydroisoquinolin-2-ium-6-ol dichloride
Synonyms of Cephaeline hydrochloride (CAS NO.5853-29-2) : (-)-Cephaeline dihydrochloride ; 7',10,11-Trimethoxyemetan-6'-ol dihydrochloride ; Cephaeline HCL ; Cephaleine hydrochloride
CAS NO:5853-29-2
Molecular Formula: C28H40Cl2N2O4
Molecular Weight :539.5342
Molecular Structure :

Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LDLo subcutaneous 8mg/kg (8mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 10, Pg. 73, 1917/1918.
mouse LD50 intraperitoneal 20530ug/kg (20.53mg/kg)   National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. Vol. JAN1986,
mouse LD50 oral 74970ug/kg (74.97mg/kg)   National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. Vol. JAN1986,
rat LD50 intraperitoneal 10mg/kg (10mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 104, Pg. 421, 1952.
rat LDLo subcutaneous 6500ug/kg (6.5mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 10, Pg. 73, 1917/1918.

Safety Profile

Poison by ingestion and intraperitoneal routes. When Cephaeline hydrochloride (CAS NO.5853-29-2) is heated to decomposition, it emits toxic fumes of NOx and HCl.

RIDADR 1544
HazardClass 6.1(b)
PackingGroup III

Specification

Category: Toxic Substances
Toxicity classification: Cephaeline hydrochloride (CAS NO.5853-29-2) is highly toxic.
Acute toxicity: abdominal - rat LD50: 10 mg / kg; Oral - Mouse LD50: 74.97 mg / kg
Flammable hazardous characteristics: thermal decomposition of toxic emissions of nitrogen oxides, hydrogen chloride fumes
Storage features: Treasury temperature, ventilation, drying; and keep separately from food raw materials
Fire-extinguishing agent: water, carbon dioxide, foam, dry powder