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| CAS No.: | 59-63-2 |
|---|---|
| Name: | ISOCARBOXAZID (200 MG) |
| Molecular Structure: | |
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| Formula: | C12H13 N3 O2 |
| Molecular Weight: | 231.254 |
| Synonyms: | 3-Isoxazolecarboxylicacid, 5-methyl-, 2-benzylhydrazide (6CI,7CI,8CI); 1-Benzyl-2-(5-methyl-3-isoxazolyl-carbonyl)hydrazine;5-Methyl-3-isoxazolecarboxylic acid 2-benzylhydrazide; BMIH; Benazide; Enerzer;Isocarboxazid; Isocarboxazide; Isocarboxyzid; Marplan; Marplon; NSC 169893;N'-Benzyl N-methyl-5-isoxazolecarboxylhydrazide-3; Ro 5-0831 |
| Density: | 1.206g/cm3 |
| Melting Point: | 98-1000C |
| Boiling Point: | 394.5°Cat760mmHg |
| Flash Point: | 192.4°C |
| Solubility: | 0.8g/L(25 oC) |
| Safety: | A poison by ingestion, intraperitoneal, and subcutaneous routes. An experimental teratogen. Other experimental reproductive effects. Human systemic effects: monoamine oxidase effects. Mutation data reported. A pharmaceutical and veterinary drug. When heated to decomposition it emits toxic fumes of NOx. |
| PSA: | 67.16000 |
| LogP: | 2.19940 |
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Chemistry
IUPAC Name: N'-Benzyl-5-methyl-1,2-oxazole-3-carbohydrazide
Synonyms of Isocarboxazid (CAS NO.59-63-2) : 3-Isoxazolecarboxylic acid, 5-methyl-, 2-(phenylmethyl)hydrazide ; 5-Methyl-N'-(phenylmethyl)isoxazole-3-carbohydrazide ; N'-Benzyl-5-methyl-1,2-oxazole-3-carbohydrazide ; 3-(N-Benzylhydrazinocarbonyl)-5-methylisoxazole
Product Categories: All Inhibitors;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals
CAS NO:59-63-2
Molecular Formula:C12H13N3O2
Molecular Weight : 231.2505
Molecular Structure :
EINECS: 200-438-4
Index of Refraction:1.573
Surface Tension: 48.7 dyne/cm
Density: 1.206 g/cm3
Flash Point: 192.4 °C
Melting point: 98-100°C
Enthalpy of Vaporization: 64.45 kJ/mol
Boiling Point: 394.5 °C at 760 mmHg
Vapour Pressure: 1.97E-06 mmHg at 25°C
Appearance:Pale Yellow Solid
Uses
Isocarboxazid (CAS NO.59-63-2) (Enerzer, Marplan, Marplon) is an irreversible and nonselective monoamine oxidase inhibitor (MAOI) of the hydrazine chemical class used as an antidepressant and anxiolytic. It is one of the few hydrazine MAOIs still in clinical use, along with phenelzine.
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| dog | LD50 | oral | > 40mg/kg (40mg/kg) | GASTROINTESTINAL: NAUSEA OR VOMITING | Annals of the New York Academy of Sciences. Vol. 80, Pg. 626, 1959. |
| monkey | LD50 | oral | 160mg/kg (160mg/kg) | Annals of the New York Academy of Sciences. Vol. 80, Pg. 626, 1959. | |
| mouse | LD50 | intraperitoneal | 138mg/kg (138mg/kg) | Journal of Medicinal and Pharmaceutical Chemistry. Vol. 2, Pg. 133, 1960. | |
| mouse | LD50 | oral | 193mg/kg (193mg/kg) | Annals of the New York Academy of Sciences. Vol. 80, Pg. 626, 1959. | |
| mouse | LD50 | subcutaneous | 150mg/kg (150mg/kg) | Toxicology and Applied Pharmacology. Vol. 39, Pg. 141, 1977. | |
| rat | LD50 | intraperitoneal | 199mg/kg (199mg/kg) | "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 240, 1972. | |
| rat | LD50 | oral | 280mg/kg (280mg/kg) | Annals of the New York Academy of Sciences. Vol. 80, Pg. 626, 1959. | |
| women | TDLo | oral | 4800ug/kg/21W (4.8mg/kg) | Journal of Clinical Pyschopharmacology. Vol. 3, Pg. 42, 1983. | |
| women | TDLo | oral | 4800ug/kg/21W (4.8mg/kg) | Journal of Clinical Pyschopharmacology. Vol. 3, Pg. 42, 1983. |
Safety Profile
A poison by ingestion, intraperitoneal, and subcutaneous routes. An experimental teratogen. Other experimental reproductive effects. Human systemic effects: monoamine oxidase effects. Mutation data reported. A pharmaceutical and veterinary drug. When Isocarboxazid (CAS NO.59-63-2) is heated to decomposition, it emits toxic fumes of NOx.
RIDADR 3249
HazardClass 6.1(b)
PackingGroup III