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CAS No.: | 59128-97-1 |
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Name: | Haloxazolam |
Article Data: | 1 |
Molecular Structure: | |
Formula: | C17H14 Br F N2 O2 |
Molecular Weight: | 377.213 |
Synonyms: | CS 430;Haloxazolam; Somelin |
Density: | 1.64g/cm3 |
Melting Point: | 185° |
Boiling Point: | 506.8°C at 760 mmHg |
Flash Point: | 260.3°C |
Safety: | Moderately toxic by ingestion. When heated to decomposition it emits toxic fumes of F−, Br−, and NOx. An experimental teratogen. A sedative and hypnotic agent. Note: This is a controlled substance (depressant) listed in the U.S. Code of Federal Regulations, Title 21 Part 1308.14 (1985). See also DIAZEPAM. |
PSA: | 41.57000 |
LogP: | 3.14950 |
IUPAC Name: 10-bromo-11b-(2-fluorophenyl)-2,3,5,7-tetrahydro-[1,3]oxazolo[3,2-d][1,4]benzodiazepin-6-one
Synonyms: 10-Bromo-11b-(2-fluorophenyl)-2,3,7,11b-tetrahydro[1,3]oxazolo[3,2-d][1,4]benzodiazepin-6(5H)-one
Structure Descriptors :
Smiles: c12[C@@]3([N@@](CCO3)CC(=O)Nc1ccc(c2)Br)c1c(cccc1)F
Molecular Formula of Haloxazolam (CAS NO.59128-97-1 ) : C17H14BrFN2O2
Molecular Structure of Haloxazolam (CAS NO.59128-97-1 ) :
Molecular Weight: 377.21 g/mol
Index of Refraction: 1.691
Density: 1.64 g/cm3
Melting point: 185°C
Flash Point: 260.3 °C
Surface Tension: 65.3 dyne/cm
Enthalpy of Vaporization: 77.68 kJ/mol
Boiling Point: 506.8 °C at 760 mmHg
Vapour Pressure: 2.15E-10 mmHg at 25°C
Water solubility: 16.13 mg/mL (25°C)
Appearance of Haloxazolam (CAS NO.59128-97-1 ) : Colorless crystals
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
infant | TDLo | oral | 2mg/kg (2mg/kg) | SENSE ORGANS AND SPECIAL SENSES: MIOSIS (PUPILLARY CONSTRICTION): EYE BEHAVIORAL: SLEEP | Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 38, Pg. 2597, 1996. |
mouse | LD50 | intraperitoneal | > 15gm/kg (15000mg/kg) | Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 22, Pg. 1501, 1980. | |
mouse | LD50 | oral | 1413mg/kg (1413mg/kg) | BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Sankyo Kenkyusho Nempo. Annual Report of Sankyo Research Laboratories. Vol. 27, Pg. 64, 1975. |
mouse | LD50 | subcutaneous | > 15gm/kg (15000mg/kg) | Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 22, Pg. 1501, 1980. | |
rat | LD50 | intraperitoneal | > 3gm/kg (3000mg/kg) | Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 22, Pg. 1501, 1980. | |
rat | LD50 | oral | 2858mg/kg (2858mg/kg) | BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Sankyo Kenkyusho Nempo. Annual Report of Sankyo Research Laboratories. Vol. 27, Pg. 64, 1975. |
rat | LD50 | subcutaneous | > 3gm/kg (3000mg/kg) | Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 22, Pg. 1501, 1980. |
Moderately toxic by ingestion. When heated to decomposition Haloxazolam (CAS NO.59128-97-1 ) emits toxic fumes of F−, Br−, and NOx. An experimental teratogen. A sedative and hypnotic agent. Note: This is a controlled substance (depressant) listed in the U.S. Code of Federal Regulations, Title 21 Part 1308.14 (1985). See also DIAZEPAM.
RIDADR: 3249
HazardClass: 6.1(b)
PackingGroup: III
Classification Code of Haloxazolam (CAS NO. 59128-97-1 ) : Drug / Therapeutic Agent;Reproductive Effect