CAS No.592-62-1,METHYLAZOXY METHANOL ACETATE Suppliers

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Basic Information

Molecular Structure:
CAS No.:	592-62-1
Name:	METHYLAZOXY METHANOL ACETATE

Formula:	C4H8 N2 O3
Molecular Weight:	132.119
Synonyms:	Methanol,(methyl-ONN-azoxy)-, acetate (ester) (8CI,9CI);Methanol, (methylazoxy)-,acetate (ester) (7CI);Methylazoxymethanol acetate;Methylazoxymethyl acetate;NSC 87705;
EINECS:	209-765-7
Density:	1.18g/cm³
Boiling Point:	179.2°Cat760mmHg
Flash Point:	62.2°C
Solubility:	22,000 mg l-1 (e)
Hazard Symbols:	T
Risk Codes:	45-61
Safety:	Confirmed carcinogen with experimental carcinogenic, neoplastigenic, tumorigenic, and teratogenic data. Poison by ingestion, intraperitoneal, and intravenous routes. An experimental teratogen. Experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits toxic fumes of NO_x. See also ESTERS.
PSA:	67.41000
LogP:	0.62250

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Consensus Reports

IARC Cancer Review: Group 2B IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 ,1987,p. 56.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 10 ,1976,p. 121.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . EPA Genetic Toxicology Program.

Specification

Methylazoxymethanol acetate( CAS No.592-62-1) is also called (methyl-onn-azoxy)-methanoacetate(ester); (methyl-onn-azoxy)methanol,acetate(ester); (methyl-onn-azoxy)methanol,acetateester;aceticacid,(methyl-onn-azoxy)methylester; cycasinacetate; mamac; mamacetate; methylazoxymethanolacetate. Methylazoxymethanol acetate, MAM, is a neurotoxin and carcinogen which reduces DNA synthesis used in making animal models of neurological diseases including schizophrenia and epilepsy. Methylazoxymethyl acetate is used as a potent alkylating agent. It is an azo compound. Azo, compounds can detonate. This applies in particular to organic azides that have been sensitized by the addition of metal salts or strong acids.

Physical properties about Methylazoxymethanol acetate are: (1)ACD/LogP: 0.691; (2)#H bond acceptors:5; (3)#Freely Rotating Bonds: 3; (4)Index of Refraction:1.463; (5)Molar Refractivity: 30.708 cm³; (6)Molar Volume: 111.513 cm³; (7)Polarizability: 12.174 10-24cm³; (8)Surface Tension: 38.6980018615723 dyne/cm; (9)Density: 1.185 g/cm³; (10)Flash Point: 62.153 °C; (11)Enthalpy of Vaporization: 41.544 kJ/mol; (12)Boiling Point: 179.158 °C at 760 mmHg; (13)Vapour Pressure: 0.954999983310699 mmHg at 25°C

You can still convert the following datas into molecular structure:
(1)InChI=1S/C4H8N2O3/c1-4(7)9-3-5-6(2)8/h3H2,1-2H3/b6-5+;
(2)InChIKey=BELPJCDYWUCHKF-AATRIKPKSA-N;
(3)SmilesC(OC\N=[N+](/C)[O-])(C)=O

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Source
mouse	LD50	intraperitoneal	105mg/kg (105mg/kg)	JNCI, Journal of the National Cancer Institute. Vol. 62, Pg. 911, 1979.
mouse	LD50	intravenous	10mg/kg (10mg/kg)	U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#04566,
mouse	LDLo	oral	35mg/kg (35mg/kg)	Cancer Research. Vol. 30, Pg. 801, 1970.
rat	LDLo	intraperitoneal	50mg/kg (50mg/kg)	Chemico-Biological Interactions. Vol. 17, Pg. 291, 1977.