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| CAS No.: | 63-92-3 |
|---|---|
| Name: | Phenoxybenzamine hydrochloride |
| Molecular Structure: | |
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| Formula: | C18H22 Cl N O . Cl H |
| Molecular Weight: | 340.293 |
| Synonyms: | Benzenemethanamine,N-(2-chloroethyl)-N-(1-methyl-2-phenoxyethyl)-, hydrochloride (9CI);Benzylamine, N-(2-chloroethyl)-N-(1-methyl-2-phenoxyethyl)-, hydrochloride(7CI,8CI); 2-(N-Benzyl-2-chloroethylamino)-1-phenoxypropane hydrochloride;Dibenzylin; Dibenzyline chloride; Dibenzyline hydrochloride; Dibenzyran; N-(2-Chloroethyl)-N-(1-methyl-2-phenoxyethyl)benzylamine,hydrochloride; N-2-Phenoxyisopropyl-N-benzyl-b-chloroethylamine hydrochloride; NSC 37448;Phenoxybenzamine chloride; Phenoxybenzamine hydrochloride |
| EINECS: | 200-569-7 |
| Melting Point: | 137.5 ºC |
| Boiling Point: | 381.5 °C at 760 mmHg |
| Flash Point: | 184.5 °C |
| Solubility: | <0.01 g/100 mL at 18.5 ºC in water |
| Appearance: | White crystalline powder. |
| Hazard Symbols: |
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| Risk Codes: | R22;R40 |
| Safety: | Confirmed carcinogen with experimental carcinogenic and teratogenic data. Poison by intraperitoneal, intravenous, and subcutaneous routes. Human systemic effects by ingestion: changes in tubules, including acute renal failure, acute tubular necrosis. Moderately toxic by ingestion. Other experimental reproductive effects. Mutation data reported. A long-acting adrenergic blocker. When heated to decomposition it emits very toxic fumes of NOx and Cl−. |
| PSA: | 12.47000 |
| LogP: | 4.99690 |
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Chemistry
Chemical Name: Phenoxybenzamine hydrochloride
IUPAC NAME: N-Benzyl-N-(2-chloroethyl)-1-phenoxypropan-2-amine hydrochloride
CAS No.: 63-92-3
EINECS: 200-569-7
RTECS: DP3750000
RTECS Class: Tumorigen ; Drug ; Mutagen ; Reproductive Effector ; Human Data
Molecular Formula: C12H12ClNO
Molecular Weight: 221.68 g/mol
Melting Point: 137.5°C
Flash Point: 184.5 °C
Boiling Point: 381.5 °C at 760 mmHg
Storage temp.: 2-8°C
Following is the structure of Dibenzyline hydrochloride (63-92-3):
The chemical synonymous of Dibenzyline hydrochloride (63-92-3) are Bensylytnen ; Benzyl(2-chloroethyl)(1-methyl-2-phenoxyethyl)aminehydrochloride ; Dibenzyran ; Fenossibenzamina ; Fenoxybenzamin ; n-(2-Chloroethyl)-n-(1-methyl-2-phenoxyethyl)-benzenemethanaminhydrochlo ; n-(2-Chloroethyl)-n-(1-methyl-2-phenoxyethyl)-benzylaminhydrochloride ; n-2-Phenoxyisopropyl-n-benzyl-chloroethylaminehydrochloride
Toxicity Data With Reference
| 1. | mmo-sat 3 µg/plate | EMMUEG Environmental and Molecular Mutagenesis. 11 (Suppl 12)(1988),1. | ||
| 2. | mma-sat 10 µg/plate | EMMUEG Environmental and Molecular Mutagenesis. 11 (Suppl 12)(1988),1. | ||
| 3. | orl-man TDLo:7143 µg/kg/5D-I:SYS | AIMEAS Annals of Internal Medicine. 107 (1987),119. | ||
| 4. | orl-rat LDLo:800 mg/kg | JPETAB Journal of Pharmacology and Experimental Therapeutics. 110 (1954),463. | ||
| 5. | orl-mus LD50:900 mg/kg | AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. 108 (1956),102. | ||
| 6. | ipr-mus LD50:228 mg/kg | TXAPA9 Toxicology and Applied Pharmacology. 28 (1974),227. | ||
| 7. | scu-mus LD50:105 mg/kg | ARZNAD Arzneimittel-Forschung. Drug Research. 17 (1967),305. | ||
| 8. | ivn-mus LD50:63,750 µg/kg | EJPHAZ European Journal of Pharmacology. 9 (1970),289. |
Consensus Reports
NTP 10th Report on Carcinogens. IARC Cancer Review: Group 2B IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 (1987),p. 56.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 24 (1980),p. 185.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . NCI Carcinogenesis Bioassay Completed; Results Positive: mouse, rat NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD 20014) No. NCI-CG-TR-72 ,1978. .
Safety Profile
Confirmed carcinogen with experimental carcinogenic and teratogenic data. Poison by intraperitoneal, intravenous, and subcutaneous routes. Human systemic effects by ingestion: changes in tubules, including acute renal failure, acute tubular necrosis. Moderately toxic by ingestion. Other experimental reproductive effects. Mutation data reported. A long-acting adrenergic blocker. When heated to decomposition it emits very toxic fumes of NOx and Cl−.
Hazard Codes:
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Risk Statements about Dibenzyline hydrochloride (63-92-3):
R22 Harmful if swallowed.
R40 Limited evidence of a carcinogenic effect.
Safety Statements about Dibenzyline hydrochloride (63-92-3):
S22 Do not breathe dust.
S45 In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection.
Attention:
1. Storage: Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
2. Handling: All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.