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| CAS No.: | 65-47-4 | |||
|---|---|---|---|---|
| Name: | Cytidine-5'-triphosphate | |||
| Molecular Structure: | ||||
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| Formula: | C9H16 N3 O14 P3 | |||
| Molecular Weight: | 483.159 | |||
| Synonyms: | CRPPP;CTP;Cytidine Triphosphate;Magnesium CTP;Mg CTP;Triphosphate, Cytidine | |||
| EINECS: | 200-611-4 | |||
| Solubility: | Soluble | white powder | ||
| Hazard Symbols: | UN NO. | |||
| Transport Information: | HAZARD | |||
| PSA: | 299.85000 | |||
| LogP: | -1.63080 | |||
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Chemistry
Product Name: Cytidine-5'-triphosphate (CAS NO.65-47-4)
Molecular Formula: C9H16N3O14P3
Molecular Weight: 483.16g/mol
Mol File: 65-47-4.mol
Appearance: White powder
Boiling point: 849.2 °C at 760 mmHg
Flash Point: 467.4 °C
Density: 2.5 g/cm3
Water Solubility: Soluble
Surface Tension: 177.3 dyne/cm
Enthalpy of Vaporization: 140.31 kJ/mol
Vapour Pressure: 1.51E-33 mmHg at 25°C
XLogP3: -5.6
H-Bond Donor: 7
H-Bond Acceptor: 15
Product Categories: Pharmaceutical Intermediates; Nucleic acids
Uses
Cytidine-5'-triphosphate (CAS NO.65-47-4) applies to fatty liver, brain diseases such as atherosclerosis, and adjuvant therapy.
Production
With CTP as the raw material fermentation method
Fermentation, in addition to protein, taking potassium dihydrogen phosphate 6.5kg, add appropriate amount of water dissolved, add magnesium chloride 0.6kg, glucose 17.5kg, stirring to dissolve, take CMP2.5kg water dissolved with sodium hydroxide adjusted pH = 7, add water to the 70L , stirring heated to 50-60 °C, add yeast liquid 180L, maintain 30-32 °C 3h, reaction end point plus hydrochloric acid adjusted pH = 5, to stop responding. Canada trichloroacetic acid, adjusting pH = 2.5, centrifugation was clear liquid.
CMP [yeast] → [30-32 °C, 3h] fermentation broth [trichloroacetic acid] → [pH2.5] the supernatant
To salt, precipitation, purification will be clear liquid by adding strong acid styrene cation exchange resin (001 × 7), stirring adsorption 15min, so that pH = 1.5-1.7, put it aside for 30min, filtered, the filtrate added to the alcohol concentration of ethanol, 75 %, put it aside overnight, filtration, filter cake dissolved in water to a concentration of 25%, plus one-fifth the volume of diatomaceous earth filter cake, stir filter, collecting the filtrate.
Supernatant [001 × 7 resin] → [pH1.5-1.7, 15min] filtrate [ethanol] → [8h] sediment [water, diatomaceous earth] → [stirring, filter] filtrate
Adsorption, elution, bleaching take filtrate diluted with water into a 0.5% -0.6% of the solution, adjusting Ph = 2-2.5, with the strong base quaternary ammonium anion exchange resin-I (717) adsorption, the first water washing 8h, then pH 2 in 0.03mol / L of sodium chloride solution, elution ADP. in the solution absorbance at wavelength of 280nm is greater than 0.4, the switch to pH2 water washing 4h, the last with pH2 of 1mol / L NaCl elution ATP , eluate by adding one-thousandth of the amount of activated carbon, mixing, bleaching, filtration, collection of filtrate.
Filtrate [717 resin] → [pH2-2.5] adsorbate [NaCl] → [pH2] cleared [carbon] → [40min] filtrate
Precipitation, dry filtrate transferred Ph = 3-5, plus 3 times the amount of alcohol, put it aside, filtration, with anhydrous ethanol and anhydrous ether, cake washing, vacuum drying, that is, cytidine triphosphate disodium.
Filtrate [ethanol] → [pH3.5] sediments [anhydrous ethanol, anhydrous ether] → cytidine triphosphate disodium.
Toxicity Data With Reference
| 1. | oth-hmn:oth 1 mmol/L | JIDEAE Journal of Investigative Dermatology. 65 (1975),52. |
Consensus Reports
Reported in EPA TSCA Inventory.
Safety Profile
Human mutation data reported. When heated to decomposition it emits toxic vapors of NOx and POx.
Specification
Cytidine-5'-triphosphate ,its CAS NO. is 65-47-4,the synonyms is 5'-Ctp ; Cytidine,5'-(tetrahydrogentriphosphate) ; Cytidine3'-triphosphate ; Cytidine5'-(tetrahydrogentriphosphate) ; Cytidine5'-triphosphoricacid ; Cytidinetriphosphate ; Ctp .