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Basic Information
CAS No.: 65057-91-2
Name: N1-[3-[(4-Aminobutyl)amino]propyl]-13-[(4-amino-4,6-dideoxy-α-L-talopyranosyl)oxy]-19-demethyl-12-hydroxybleomycinamide
Molecular Structure:
Molecular Structure of 65057-91-2 (N1-[3-[(4-Aminobutyl)amino]propyl]-13-[(4-amino-4,6-dideoxy-α-L-talopyranosyl)oxy]-19-demethyl-12-hydroxybleomycinamide)
Formula: C62H98N20O26S2
Molecular Weight: 1603.92
Density: 1.0979 (rough estimate)
Safety: Poison by intraperitoneal, intratracheal, and intravenous routes. Mutation data reported. When heated to decomposition it emits very toxic fumes of SOx and NOx.
PSA: 826.77000
LogP: -3.35220
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    TALLYSOMYCIN B

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Chemistry

IUPAC Name: [2-[2-[2-[[6-Amino-2-[3-amino-1-[(2,3-diamino-3-oxopropyl)amino]-3-oxopropyl]-5-methylpyrimidine-4-carbonyl]amino]-3-[[5-[[1-[[2-[2-[2-[3-(4-aminobutylamino)propylcarbamoyl]-1,3-thiazol-4-yl]-1,3-thiazol-4-yl]-1-(5-amino-3,4-dihydroxy-6-methyloxan-2-yl)oxy-2-hydroxyethyl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-3-hydroxy-5-oxopentan-2-yl]amino]-1-(1H-imidazol-5-yl)-3-oxopropoxy]-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl]oxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl] carbamate 
Molecular Formula: C62H98N20O26S2
Molecular Weight: 1603.92
Density: 1.61 g/cm3 
Freely Rotating Bonds: 56
Polar Surface Area: 826.77 Å2
Index of Refraction: 1.695
Molar Refractivity: 381.22 cm3
Molar Volume: 991.2 cm3
Polarizability: 151.12 ×10-24 cm3
Surface Tension: 112.2 dyne/cm
The Cas Register Number  of Tallysomycin B is 65057-91-2.The chemical synonyms of Tallysomycin B (CAS NO.65057-91-2) are Antibiotic BU-2231B ; BU-2231B ; N1-[3-[(4-Aminobutyl)amino]propyl]-13-[(4-amino-4,6-dideoxy-α-L-talopyranosyl)oxy]-19-demethyl-12-hydroxybleomycinamide ; Talisomycin B ; Tallysomycin B .The molecular structure of Tallysomycin B (CAS NO.65057-91-2) is.

Uses

 Tallysomycin B (CAS NO.65057-91-2)  is used as pharmaceutical intermediate.

Toxicity Data With Reference

1.    

mmo-sat 50 ng/plate

    MUREAV    Mutation Research. 117 (1983),9.
2.    

ipr-mus LD50:46 mg/kg

    JANTAJ    Journal of Antibiotics. 30 (1977),779.
3.    

ivn-mus LD50:30 mg/kg

    JANTAJ    Journal of Antibiotics. 30 (1977),779.
4.    

itr-mus LDLo:16 µg/kg

    TXAPA9    Toxicology and Applied Pharmacology. 56 (1980),326.

Safety Profile

Poison by intraperitoneal, intratracheal, and intravenous routes. Mutation data reported. When heated to decomposition it emits very toxic fumes of SOx and NOx.