CAS No.65807-02-5,Goserelin Suppliers

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Basic Information

Molecular Structure:
CAS No.:	65807-02-5
Name:	Goserelin

Formula:	C₅₉H₈₄N₁₈O₁₄
Molecular Weight:	1269.41
Synonyms:	Luteinizinghormone-releasing factor (pig),6-[O-(1,1-dimethylethyl)-D-serine]-10-deglycinamide-,2-(aminocarbonyl)hydrazide;Decapeptide I;Goserelin;ICI 118630;Zoladex;Luteinizing hormone-releasing factor (pig), 6-(O-(1,1-dimethylethyl)-D-serine)-10-deglycinamide-, 2-(aminocarbonyl)hydrazide;Goserelinum;Goserelina;Gosereline;
Density:	1.5 g/cm³
Appearance:	white solid
Safety:	22-24/25
PSA:	493.39000
LogP:	2.78000

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Specification

The CAS registry number of Goserelin acetate is 65807-02-5. The systematic name is 5-oxo-L-prolyl-L-histidyl-N-[(1S,4S,7R,10S,13S)-18,18-diamino-7-(tert-butoxymethyl)-13-({(2S)-2-[(2-carbamoylhydrazino)carbonyl]pyrrolidin-1-yl}carbonyl)-4-(4-hydroxybenzyl)-1-(hydroxymethyl)-10-(2-me thylpropyl)-2,5,8,11-tetraoxo-3,6,9,12,17-pentaazaoctadec-17-en-1-yl]-L-tryptophanamide. In addition, the molecular formula is C₅₉H₈₄N₁₈O₁₄ and the molecular weight is 1269.41. It is also called Goserelina. And it is a synthetic long-acting agonist of gonadotropin-releasing hormone and it should be stored in a cool and dry place.

Physical properties about this chemical are: (1)ACD/LogP: -0.45; (2)# of Rule of 5 Violations: 3; (3)ACD/LogD (pH 5.5): -3.5; (4)ACD/LogD (pH 7.4): -2.52; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 1; (8)ACD/KOC (pH 7.4): 1; (9)#H bond acceptors: 32; (10)#H bond donors: 20; (11)#Freely Rotating Bonds: 35; (12)Polar Surface Area: 295.93 Å²; (13)Index of Refraction: 1.692; (14)Molar Refractivity: 323.71 cm³; (15)Molar Volume: 844.7 cm³; (16)Polarizability: 128.32 ×10^-24cm³; (17)Surface Tension: 65.8 dyne/cm; (18)Density: 1.5 g/cm³.

Uses of Goserelin acetate: it can be used to suppress production of the sex hormones (testosterone and oestrogen), particularly in the treatment of breast and prostate cancer. And it is used to treat some benign gynaecological disorders (endometriosis, uterine fibroids and endometrial thinning). In addition, it is used in assisted reproduction and in the treatment of precocious puberty. Besides, it is available as a 1-month depot and a long-acting 3-month depot.

When you are using this chemical, please be cautious about it as the following:
During using it, you should avoid contact with skin and eyes. In addition, do not breathe dust.

You can still convert the following datas into molecular structure:
(1)SMILES: O=C(N)NNC(=O)[C@H]6N(C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H]1NC(=O)CC1)Cc2cncn2)Cc4c3ccccc3nc4)CO)Cc5ccc(O)cc5)COC(C)(C)C)CC(C)C)CCC/N=C(\N )N)CCC6
(2)InChI: InChI=1/C59H84N18O14/c1-31(2)22-40(49(82)68-39(12-8-20-64-57(60)61)56(89)77-21-9-13-46(77)55(88)75-76-58(62)90)69-54(87)45(29-91-59(3,4)5)74-50(83)41(23-32-14-16-35(79)17-15-32)70-53(86)44(28-78)73-51(84)42(24-33-26-65-37-11-7-6-10-36(33)37)71-52(85)43(25-34-27-63-30-66-34)72-48(81)38-18-19-47(80)67-38/h6-7,10-11,14-17,26-27,30-31,38-46,65,78-79H,8-9,12-13,18-25,28-29H2,1-5H3,(H,63,66)(H,67,80)(H,68,82)(H,69,87)(H,70,86)(H,71,85)(H,72,81)(H,73,84)(H,74,83)(H,75,88)(H4,60,61,64)(H3,62,76,90)/t38-,39-,40-,41-,42-,43-,44-,45+,46-/m0/s1
(3)InChIKey: BLCLNMBMMGCOAS-URPVMXJPBD

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
man	TDLo	subcutaneous	51ug/kg (0.051mg/kg)	BRAIN AND COVERINGS: "CHANGES IN CIRCULATION (HEMORRHAGE, THROMBOSIS, ETC.)" SENSE ORGANS AND SPECIAL SENSES: DIPLOPIA: EYE	Lancet. Vol. 345, Pg. 458, 1995.