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Basic Information
CAS No.: 66922-67-6
Name: N-Ethyl-N-(p-ethoxyphenyl)acetamide
Molecular Structure:
Molecular Structure of 66922-67-6 (N-Ethyl-N-(p-ethoxyphenyl)acetamide)
Formula: C12H17NO2
Molecular Weight: 207.30
Synonyms: p-ACETOPHENETIDIDE,N-ETHYL;Ethylphenacetin;N-Aethyl-phenacetin;
Density: 1.046g/cm3
Boiling Point: 324.3°Cat760mmHg
Flash Point: 149.9°C
Safety: Moderately toxic by ingestion. When heated to decomposition it emits toxic fumes of NOx.
PSA: 29.54000
LogP: 2.45810
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Chemistry

IUPAC Name: N-(4-Ethoxyphenyl)-N-ethylacetamide
Synonyms of Ethylphenacetin (CAS NO.66922-67-6): p-Acetophenetidide, N-ethyl-
CAS NO: 66922-67-6
Molecular Formula: C12H17NO2
Molecular Weight : 207.268880 g/mol
Molecular Structure:
H bond acceptors: 3
H bond donors: 0
Freely Rotating Bonds: 4
Polar Surface Area: 29.54 Å2
Index of Refraction: 1.529
Molar Refractivity: 61.17 cm3
Molar Volume: 198 cm3
Surface Tension: 37.5 dyne/cm
Density: 1.046 g/cm3
Flash Point: 149.9 °C
Enthalpy of Vaporization: 56.63 kJ/mol
Boiling Point: 324.3 °C at 760 mmHg
Vapour Pressure: 0.000248 mmHg at 25°C

Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
frog LDLo oral 3gm/kg (3000mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

CARDIAC: PULSE RATE

CARDIAC: OTHER CHANGES		 Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 33, Pg. 216, 1894.
guinea pig LDLo oral 2700mg/kg (2700mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ATAXIA

CARDIAC: OTHER CHANGES		 Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 33, Pg. 216, 1894.
rabbit LDLo oral 2500mg/kg (2500mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA

BLOOD: OTHER CHANGES		 Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 33, Pg. 216, 1894.

Safety Profile

Moderately toxic by ingestion. When Ethylphenacetin (CAS NO.66922-67-6) is heated to decomposition, it emits toxic fumes of NOx.