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68439-86-1

Basic Information
CAS No.: 68439-86-1
Name: Bone, ash
Molecular Structure:
Molecular Structure of 68439-86-1 (Bone, ash)
Formula: Ca5HO13P3
Molecular Weight: 502.31
Synonyms: Ash bone;Bone ash; Bone Ash 325; HA 216
EINECS: 231-840-8
Density:
Melting Point: 1100ºC(lit.)
Boiling Point:
Flash Point:
Solubility:
Appearance: solid
Hazard Symbols: IrritantXi
Risk Codes: 36/37/38
Safety: 26-36
Transport Information:
PSA:
LogP:
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Chemistry

Chemical Name: Hydroxylapatite
CAS No.: 68439-86-1
EINECS: 231-840-8
RTECS: MY8434000
Molecular Formula: Ca5HO13P3
Molecular Weight: 502.31 g/mol
Melting Point: 1100 °C(lit.)
Following is the structure of Hydroxylapatite (CAS No.:68439-86-1):


The chemical synonymous of Hydroxylapatite (CAS No.:68439-86-1) are Beef bone powder ; Bone ash ; Apatite hap, monoclinic ; Calcium phosphate hydroxide ; Calcium phosphate tribasic ; Calcium hydroxide phosphate ; Calcium hydroxyapatite ; Durapatite

Uses

Hydroxylapatite (CAS No.:68439-86-1) can be found in teeth and bones within the human body.Thus, it is commonly used as a filler to replace amputated bone or as a coating to promote bone ingrowth into prosthetic implants. Although many other phases exist with similar or even identical chemical makeup, the body responds much differently to them. Coral skeletons can be transformed into hydroxylapatite by high temperatures; their porous structure allows relatively rapid ingrowth at the expense of initial mechanical strength.

Safety Profile

Hazard Codes: IrritantXi
Risk Statements about Hydroxylapatite (CAS No.:68439-86-1):
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements about Hydroxylapatite (CAS No.:68439-86-1):
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S36:Wear suitable protective clothing.
Attention:
1. Storage: Store in a cool, dry place. Store in a tightly closed container.
2. Handling: Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes. Avoid ingestion and inhalation.

Specification

Hydroxylapatite (CAS No.:68439-86-1) is a naturally occurring mineral form of calcium apatite with the formula Ca5(PO4)3(OH), but is usually written Ca10(PO4)6(OH)2 to denote that the crystal unit cell comprises two entities.It is the hydroxyl endmember of the complex apatite group. The OH- ion can be replaced by fluoride, chloride or carbonate, producing fluorapatite or chlorapatite. It crystallizes in the hexagonal crystal system. It has a specific gravity of 3.08 and is 5 on the Mohs hardness scale. Pure hydroxylapatite powder is white. Naturally occurring apatites can however also have brown, yellow or green colorations, comparable to the discolorations of dental fluorosis.Up to fifty percent of bone is made up of a modified form of the inorganic mineral hydroxylapatite.Carbonated-calcium deficient hydroxylapatite is the main mineral of which dental enamel and dentin are comprised. Hydroxyapatite crystals are also found in the small calcifications (within the pineal gland and other structures) known as corpora arenacea or 'brain sand'.It is marketed as a "bone-building" supplement with superior absorption than calcium.It is a second-generation calcium supplement derived from bovine bone.In the 1980s, bone meal calcium supplements were found to be contaminated with heavy metals,and although the manufacturers' claim their MH is free from contaminants, people are advised to avoid it because it has not been well-tested.However, the limited tests seem to show positive results. A 1995 randomized placebo-controlled study of 40 people in Europe found that it was more effective than calcium carbonate in slowing bone loss.A 2007 randomized double-blind controlled study of an MH supplement called the Bone Builder found significant positive effects in bone mineral density (BMD).