CAS No.69712-56-7,Cefotetan disodium Suppliers

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Basic Information

Molecular Structure:
CAS No.:	69712-56-7
Name:	Cefotetan disodium
Article Data:	7

Formula:	C₁₇H₁₇N₇O₈S₄
Molecular Weight:	575.628
Synonyms:	5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid,7-[[[4-(2-amino-1-carboxy-2-oxoethylidene)-1,3-dithietan-2-yl]carbonyl]amino]-7-methoxy-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-,[6R-(6a,7a)]-;Apacef;
EINECS:	274-093-3
Density:	2.07 g/cm³
Melting Point:	173-178°C (dec.)
Appearance:	Off-white solid
PSA:	321.13000
LogP:	-0.36840

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Chemistry

Molecular Structure of Cefotetan disodium (CAS NO.69712-56-7):

IUPAC Name: (6R,7S)-7-[[4-(1-amino-3-hydroxy-1,3-dioxopropan-2-ylidene)-1,3-Dithietane-2-carbonyl]amino]-7-methoxy-3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
CAS: 69712-56-7
Empirical Formula: C₁₇H₁₇N₇O₈S₄
Molecular Weight: 575.62
EINECS: 277-834-9
H bond acceptors: 15
H bond donors: 5
Freely Rotating Bonds: 9
Polar Surface Area: 321.13Å²
Index of Refraction: 1.921
Molar Refractivity: 131.49 cm³
Molar Volume: 278 cm³
Surface Tension: 111 dyne/cm
Density: 2.07 g/cm³
Mol File: 69712-56-7.mol
Density: 2.07 g/cm³
Storage temp: Store at 0-5°C
Synonyms: (6R,7S)-4-((2-Carboxy-7-methoxy-3-(((1-methyl-1H-tetrazol-5-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-en-7-yl)carbamoyl)-1,3-dithietane-delta(sup 2,alpha)-malonamic acid ; (6R,7S)-7-(4-(Carbamoylcarboxymethylene)-1,3-dithiethane-2-carboxamido)-7-methoxy-3-(((1-methyl-1H-tetrazol-5-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid

Uses

Cefotetan disodium (CAS NO.69712-56-7) is an injectable antibiotic of the cephamycin type for prophylaxis and treatment of bacterial infections. It is often grouped together with second-generation cephalosporins and has a similar antibacterial spectrum, but with additional anti-anaerobe converage.

Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LD50	intravenous	> 6gm/kg (6000mg/kg)		Yakkyoku. Pharmacy. Vol. 35, Pg. 2033, 1984.
mouse	LD50	intraperitoneal	8120mg/kg (8120mg/kg)	SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LIVER: OTHER CHANGES	Chemotherapy Vol. 30(Suppl,
mouse	LD50	intravenous	4990mg/kg (4990mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BLOOD: CHANGES IN SPLEEN	Chemotherapy Vol. 30(Suppl,
mouse	LD50	oral	> 10gm/kg (10000mg/kg)	GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"	Chemotherapy Vol. 30(Suppl,
mouse	LD50	subcutaneous	> 10gm/kg (10000mg/kg)	BEHAVIORAL: TREMOR SKIN AND APPENDAGES (SKIN): HAIR: OTHER	Chemotherapy Vol. 30(Suppl,
rat	LD50	intraperitoneal	8250mg/kg (8250mg/kg)	SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BLOOD: CHANGES IN SPLEEN	Chemotherapy Vol. 30(Suppl,
rat	LD50	intravenous	5gm/kg (5000mg/kg)		"Current Chemotherapy and Infectious Diseases, Proceedings of the 11th International Congress of Chemotherapy and the 19th Interscience Conference on Antimicrobial Agents and Chemotherapy, Boston, MA, 1979," Washington, DC, American Soc. for Microbiology, 1980Vol. 1, Pg. 273, 1980.
rat	LD50	oral	> 10gm/kg (10000mg/kg)	GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"	Chemotherapy Vol. 30(Suppl,
rat	LD50	subcutaneous	> 10gm/kg (10000mg/kg)	BEHAVIORAL: TREMOR SKIN AND APPENDAGES (SKIN): HAIR: OTHER	Chemotherapy Vol. 30(Suppl,

Specification

Cefotetan disodium (CAS NO.69712-56-7) is a white to pale yellow powder which is very soluble in water. Reconstituted solutions of Cefotetan disodium (Cefotetan disodium disodium for injection) are intended for intravenous and intramuscular administration. The solution varies from colorless to yellow depending on the concentration. The pH of freshly reconstituted solutions is usually between 4.5 to 6.5.

Cefotetan disodium in the ADD-Vantage Vial† is intended for intravenous use only after dilution with the appropriate volume of ADD-Vantage diluent solution. Cefotetan disodium (CAS NO.69712-56-7) is a parenteral, semisynthetic cephalosporin antibiotic. Reproduction studies in rats and monkeys found no evidence of impaired fertility or fetal harm at doses up to 20 times the human dose. Cephalosporins are usually considered safe to use during pregnancy.

The chemical structure of Cefotetan disodium , like that of several other cephalosporins, contains an N-methylthiotetrazole (NMTT or 1-MTT) side chain. As the antibiotic is broken down in the body, it releases free NMTT, which can cause hypoprothrombinemia (likely due to inhibition of the enzyme vitamin K epoxide reductase) and a reaction with ethanol similar to that produced by disulfiram (Antabuse), due to inhibition of aldehyde dehydrogenase. Cefotetan disodium disodium is a semisynthetic, beta-lactamase resistant, cephalosporin (cephamycin) antibiotic.