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74220-04-5

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Basic Information
CAS No.: 74220-04-5
Name: 1-[4-(2-methoxyethyl)phenoxy]-3-(propan-2-ylamino)propan-2-ol 2,3-dihydroxybutanedioate (2:1)
Article Data: 3
Molecular Structure:
Molecular Structure of 74220-04-5 (1-[4-(2-methoxyethyl)phenoxy]-3-(propan-2-ylamino)propan-2-ol 2,3-dihydroxybutanedioate (2:1))
Formula: N/A
Molecular Weight: 417.456
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Chemistry

IUPAC Name: (2R,3R)-2,3-Dihydroxybutanedioic acid;1-[4-(2-methoxyethyl)phenoxy]-3-(propan-2-ylamino)propan-2-ol
The MF of Seloken (CAS NO.74220-04-5) is C34H56N2O12.

                 
The MW of Seloken (CAS NO.74220-04-5) is 684.81464.
Synonyms of Seloken (CAS NO.74220-04-5): 1-Isopropylamino-3-(p-(2-methoxyethyl)phenoxy)-2-propanol (2:1) dextro-tartrate salt ; 2-Propanol, 1-(isopropylamino)-3-(p-(2-methoxyethyl)phenoxy)-, (+-)-, tartrate (2:1)
Enthalpy of Vaporization: 68.47 kJ/mol
Flash Point: 194.9 °C   
Boiling Point: 398.6 °C

Uses

  Seloken (CAS NO.74220-04-5) is a selective adrenergic beta-1-blocking agent with no stimulatory action. It's binding to plasma albumin is weaker than alprenolol and it may be useful in angina pectoris, hypertension, or cardiac arrhythmias.

Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 oral 1090mg/kg (1090mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 14, Pg. 297, 1983.
human TDLo oral 160mg/kg (160mg/kg) CARDIAC: PULSE RATE

VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION

LUNGS, THORAX, OR RESPIRATION: CYANOSIS		 British Medical Journal. Vol. 1, Pg. 222, 1976.
mouse LD50 intraperitoneal 202mg/kg (202mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 24, Pg. 2439, 1982.
mouse LD50 intravenous 84mg/kg (84mg/kg)   Drugs in Japan Vol. -, Pg. 614, 1995.
mouse LD50 oral 1500mg/kg (1500mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD		 Kiso to Rinsho. Clinical Report. Vol. 13, Pg. 2839, 1979.
mouse LD50 subcutaneous 510mg/kg (510mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD		 Kiso to Rinsho. Clinical Report. Vol. 13, Pg. 2839, 1979.
rabbit LD50 intravenous 28700ug/kg (28.7mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 14, Pg. 297, 1983.
rabbit LD50 oral 604mg/kg (604mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 14, Pg. 297, 1983.
rat LD50 intraperitoneal 219mg/kg (219mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 24, Pg. 2439, 1982.
rat LD50 intravenous 90mg/kg (90mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION		 Kiso to Rinsho. Clinical Report. Vol. 13, Pg. 2839, 1979.
rat LD50 oral 5500mg/kg (5500mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD		 Kiso to Rinsho. Clinical Report. Vol. 13, Pg. 2839, 1979.
rat LD50 subcutaneous 1150mg/kg (1150mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD		 Kiso to Rinsho. Clinical Report. Vol. 13, Pg. 2839, 1979.

Safety Profile

Poison by intravenous route. Moderately toxic by ingestion. Human systemic effects by ingestion: decreased blood pressure along with possible decrease in pulse rate, and cyanosis. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx.