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7446-18-6

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Basic Information
CAS No.: 7446-18-6
Name: Sulfuric acid,thallium(1+) salt (1:2)
Molecular Structure:
Molecular Structure of 7446-18-6 (Sulfuric acid,thallium(1+) salt (1:2))
Formula: H2O4 S . 2 Tl
Molecular Weight: 504.80
Synonyms: Sulfuricacid, dithallium(1+) salt (8CI,9CI);Thallium sulfate (Tl2(SO4)) (6CI);C.F.S.;CSF-Giftweizen;Dithallium sulfate;Dithallium(1+) sulfate;Dithallium(I)sulfate;M 7-Giftkoerner;Rattengiftkonserve;Thallium sulfate;Thallium(I)sulfate;Thallous sulfate;Zelio;
EINECS: 231-201-3
Density: 6.77g/mLat 25°C(lit.)
Melting Point: 632°C(lit.)
Boiling Point:
Flash Point:
Solubility:
Appearance: white fine crystalline powder or needles
Hazard Symbols: As for thallium.
Risk Codes: R28;R38;R48/25;R51/53;
Safety: Human poison by ingestion. Experimental poison by ingestion and subcutaneous routes. Human systemic effects by ingestion: ataxia, change in heart rate, excitement, eye changes, irritability, nausea or vomiting, nerve or sheath structural changes, somnolence, wakefulness. Experimental reproductive effects. When heated to decomposition it emits very toxic fumes of Tl and SOx. Used as a rat poison, ant bait, and a reagent in analytical chemistry. See also THALLIUM COMPOUNDS and SULFATES.
Transport Information:
PSA: 88.64000
LogP: -0.25720
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Chemistry

IUPAC Name: Thallium(1+) sulfate
Synonyms: C.F.S. ; CSF-Giftweizen ; Dithallium(1+) sulfate ; Eccothal;M 7-Giftkoerner ; M7-giftkoerner
Product Categories: Inorganics;RodenticidesAlphabetic;Alpha sort;Pesticides;Pesticides&Metabolites;Q-ZPesticides&Metabolites;TF - TO;Metal and Ceramic Science;Salts;Thallium Salts;Catalysis and Inorganic Chemistry;Chemical Synthesis;Thallium
CAS: 7446-18-6
Molecular Formula:O4STl2
Molecular Weight:504.83
Molecular Struture:
EINECS: 231-201-3
Mol File: 7446-18-6.mol
Enthalpy of Vaporization: 62.94 kJ/mol 
Boiling Point: 330 °C at 760 mmHg 
Vapour Pressure: 3.35E-05 mmHg at 25°C 
Melting point: 632 °C(lit.)
Density : 6.77 g/mL at 25 °C(lit.)
Storage temp:  Poison room
Merck : 14,9269
Appearance: Thallium(i) sulfate (2:1) is white fine crystalline powder or needles
 

Uses

Thallium(i) sulfate (2:1) is used as a rodenticide and chemical reagents.

Production

Thallium(i) sulfate (2:1) can be derived from heating of metal thallium and sulfuric acid .

Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
bird - wild LDLo oral 37mg/kg (37mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 48, Pg. 478, 1933.
cat LDLo oral 40mg/kg (40mg/kg)   Yakkyoku. Pharmacy. Vol. 28, Pg. 329, 1977.
dog LDLo oral 16mg/kg (16mg/kg)   Yakkyoku. Pharmacy. Vol. 28, Pg. 329, 1977.
duck LDLo oral 74mg/kg (74mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 48, Pg. 478, 1933.
human LDLo oral 2166ug/kg (2.166mg/kg)   Yakkyoku. Pharmacy. Vol. 28, Pg. 329, 1977.
man LDLo oral 3mg/kg (3mg/kg) SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE

BEHAVIORAL: ATAXIA

BEHAVIORAL: IRRITABILITY
"Metal Toxicity in Mammals, Vol. 2: Chemical Toxicity of Metals and Metalloids," Venugopal, B., and T.D. Luckey, New York, Plenum Press, 1978Vol. 2, Pg. 101, 1978.
man LDLo oral 14mg/kg (14mg/kg) PERIPHERAL NERVE AND SENSATION: STRUCTURAL CHANGE IN NERVE OR SHEATH

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

CARDIAC: CHANGE IN RATE
Journal of Toxicological Sciences. Vol. 3, Pg. 325, 1978.
man TDLo oral 7ug/kg (0.007mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"

SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Clinical Toxicology. Vol. 17, Pg. 133, 1980.
mouse LD50 oral 23500ug/kg (23.5mg/kg)   Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 29(2), Pg. 23, 1964.
mouse LD50 subcutaneous 26600ug/kg (26.6mg/kg)   Medycyna Pracy. Industrial Medicine. Vol. 30, Pg. 257, 1979.
pig LDLo oral 2mg/kg (2mg/kg)   Yakkyoku. Pharmacy. Vol. 28, Pg. 329, 1977.
quail LDLo oral 29640ug/kg (29.64mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 48, Pg. 478, 1933.
rabbit LD50 unreported 25mg/kg (25mg/kg)   "Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc of Chemistry, 1983-86Vol. A390, Pg. 1983,
rabbit LDLo intravenous 25mg/kg (25mg/kg)   Technical Bulletin - United States Department of Agriculture, Washington, D.C.).Vol. 238, Pg. 1, 1931.
rat LD50 oral 16mg/kg (16mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 22, Pg. 291, 1980.
rat LD50 skin 550mg/kg (550mg/kg) BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. Vol. 18, Pg. S209, 1993.
rat LD50 unreported 15mg/kg (15mg/kg)   Yakkyoku. Pharmacy. Vol. 30, Pg. 397, 1979.
rat LDLo subcutaneous 13mg/kg (13mg/kg)   Acta Pharmacologica et Toxicologica. Vol. 12, Pg. 260, 1956.
women TDLo oral 175mg/kg (175mg/kg) PERIPHERAL NERVE AND SENSATION: PARESTHESIS

KIDNEY, URETER, AND BLADDER: OTHER CHANGES IN URINE COMPOSITION

SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Journal of Toxicology, Clinical Toxicology. Vol. 35, Pg. 97, 1997.

Consensus Reports

EPA Extremely Hazardous Substances List. Thallium and its compounds are on the Community Right-To-Know List. Reported in EPA TSCA Inventory.

Safety Profile

Hazard Codes  T+,N Risk Statements  28-38-48/25-51/53
28:  Very Toxic if swallowed 
38:  Thallium(i) sulfate (2:1) is irritating to the skin 
48/25:  Toxic: danger of serious damage to health by prolonged exposure if swallowed 
48/25:  Toxic: danger of serious damage to health by prolonged exposure if swallowed  
Safety Statements  13-36/37-45-61
13:  Keep away from food, drink and animal feeding stuffs 
45:  In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) 
61:  Avoid release to the environment. Refer to special instructions safety data sheet 
36/37:  Wear suitable protective clothing and gloves  
RIDADR  UN 1707 6.1/PG 2
WGK Germany  2
RTECS  XG6800000
HazardClass  6.1
PackingGroup  II

Standards and Recommendations

OSHA PEL: TWA 0.1 mg(Tl)/m3 (skin)
ACGIH TLV: TWA 0.1 mg(Tl)/m3 (skin)

Specification

1.General Description: Odorless white rhomboid prisms or a dense white powder. Density 6.77 g / cm3. Melting point 1170°F (632°C). Extremely toxic by ingestion. Very toxic by skin absorption and ingestion. A slow acting cumulative poison. Used as a rat poison, and an ant bait. Also used for analysis (testing for iodine in the presence of chlorine) and ozonometry. Not registered as a pesticide in the U.S.
2.Air & Water: Reactions Soluble in water.
3.Reactivity Profile : Thallium(i) sulfate has weak oxidizing and weak reducing powers. Redox reactions can however still occur.
4.Health Hazard :Rated as extremely toxic. The probable oral lethal dose in humans is 5 to 50 mg/kg, or between 7 drops and 1 teaspoon for a 150-pound person. The mean lethal dose in an adult is probably about 1 gm of Thallium(i) sulfate. Chronic exposure causes hair loss starting 10 days after exposure and complete baldness in about a month.
5.Fire Hazard :When heated to decomposition, Thallium(i) sulfate (2:1) emits very toxic fumes of thallium and sulfur oxide.