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Basic Information
CAS No.: 7519-36-0
Name: N-NITROSO-L-PROLINE
Molecular Structure:
Molecular Structure of 7519-36-0 (N-NITROSO-L-PROLINE)
Formula: C5H8 N2 O3
Molecular Weight: 144.13
Synonyms: Proline,1-nitroso-, L- (8CI); 1-Nitroso-L-proline; N-Nitroso-L-proline;N-Nitrosoproline; NSC 109545
Density: 1.572g/cm3
Melting Point: 108-109°C
Boiling Point: 391.692oC at 760 mmHg
Flash Point: 190.688oC
Safety: Poison by intraperitoneal route. Questionable carcinogen with experimental tumorigenic data. Many nitroso compounds are carcinogens. When heated to decomposition it emits toxic fumes of NOx. See also NITROSO COMPOUNDS.
PSA: 69.97000
LogP: 0.15470
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Chemistry

IUPAC Name: 1-Nitrosopyrrolidine-2-carboxylic acid
The molecular formula of Nitrosoproline (CAS NO.7519-36-0) is C5H8N2O3.

                                     
The molecular weight of Nitrosoproline (CAS NO.7519-36-0) is 144.13.
Synonyms of Nitrosoproline (CAS NO.7519-36-0): 1-Nitrosoproline ; Proline, 1-nitroso- ; 1-Nitroso-pyrrolidine-2-carboxylic acid
Product Categories: Amino Acids 13C, 2H, 15N;Amino Acids & Derivatives
Apperance: Colourless Plates
Index of Refraction: 1.629  
Density: 1.57 g/ml 
Flash Point: 190.7 °C
Boiling Point: 391.7 °C
Melting Point: 108-109 °C

Uses

 Nitrosoproline (CAS NO.7519-36-0) is a nitrosoamino acid with oncogenicity.

Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 203mg/kg (203mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

GASTROINTESTINAL: OTHER CHANGES
Journal of Medicinal Chemistry. Vol. 16, Pg. 583, 1973.

Consensus Reports

IARC Cancer Review: Group 3 IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 ,1987,p. 56.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Inadequate Evidence IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 17 ,1978,p. 303.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) .

Safety Profile

Poison by intraperitoneal route. Questionable carcinogen with experimental tumorigenic data. Many nitroso compounds are carcinogens. When heated to decomposition it emits toxic fumes of NOx. See also NITROSO COMPOUNDS.