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| CAS No.: | 76-44-8 |
|---|---|
| Name: | HEPTACHLOR |
| Molecular Structure: | |
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|
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| Formula: | C10H5 Cl7 |
| Molecular Weight: | 373.321 |
| Synonyms: | 4,7-Methanoindene,1,4,5,6,7,8,8-heptachloro-3a,4,7,7a-tetrahydro- (8CI); 1,4,5,6,7,10,10-Heptachloro-4,7,8,9-tetrahydro-4,7-methyleneindene;1,4,5,6,7,8,8-Heptachloro-3a,4,7,7a-tetrahydro-4,7-methanoindene;1,4,5,6,7,8,8-Heptachloro-3a,4,7,7a-tetrahydro-4,7-endo-methanoindene;3-Chlorochlordene; Aahepta; Agroceres; Arbinex 30TN; E 3314; ENT 15,152; GPKh;Hepta; Heptachlor; Heptachlorane; Heptox; NSC 8930; Rhodiachlor; Velsicol 104 |
| EINECS: |
200-962-3 Annex I Index No: 602-046-00-2 |
| Density: | 1.57 |
| Melting Point: | 95 - 96 C |
| Boiling Point: | decomposes |
| Flash Point: | 11oC |
| Solubility: |
Stability
Toxicology
|
| Appearance: | white crystalline solid |
| Hazard Symbols: | Toxic by ingestion, inhalation, and skin absorption; use has been restricted and discontinued except for termite control. TLV: 0.5 mg/m3; animal carcinogen. |
| Risk Codes: | 24/25-33-40-50/53-39/23/24/25-23/24/25-11-67-65-38-51/53 |
| Safety: |
Confirmed carcinogen with experimental carcinogenic data. A poison by ingestion, skin contact, intraperitoneal, and intravenous routes. Human mutation data reported. Acute exposure and chronic doses have caused liver damage. See also closely related chlordane. In humans, a dose of 1–3 g can cause serious symptoms, especially where liver impairment is the case. Acute symptoms include tremors, convulsions, kidney damage, respiratory collapse, and death. When heated to decomposition it emits toxic fumes of Cl−. NOTE: The EPA has canceled registration of pesticides containing heptachlor with the exception of its use for termite control by subsurface ground insertion external to the dwelling. |
| PSA: | 0.00000 |
| LogP: | 5.24150 |
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Chemistry
CAS: 76-44-8
EINECS: 200-962-3
Product Categories: 2000/60/ECMore...Close... ; Alpha sort ; Baby Food Directives 13/2003 EC&14/2003 ECPesticides ; CyclodienesPesticides&Metabolites ; European Community: ISO and DIN;H;HA -HTMethod Specific ; H-MAlphabetic;Insecticides ; Method Specific ; Oeko-Tex Standard 100 ; PesticidesMethod Specific ; ASTM 4947: Analysis of Chlordane and Heptachlor in AirPesticides ; ASTM Air Monitoring ; 2000/60/EC ; Pesticides .
Following is the Molecular Structure of Heptachlor (76-44-8):
SMILES: ClC1/C=C\C2C3(Cl)C(\Cl)=C(\Cl)C(Cl)(C12)C3(Cl)Cl
InChI: InChI=1/C10H5Cl7/c11-4-2-1-3-5(4)9(15)7(13)6(12)8(3,14)10(9,16)17/h1-5H
InChIKey: FRCCEHPWNOQAEU-UHFFFAOYAM
Std.InChI: InChI=1S/C10H5Cl7/c11-4-2-1-3-5(4)9(15)7(13)6(12)8(3,14)10(9,16)17/h1-5H
Std.InChIKey: FRCCEHPWNOQAEU-UHFFFAOYSA-N
Molecular Formula: C10H5Cl7
Molecular Weight: 373.32
Melting Point:
Boiling Point: 392.3℃ at 760mmHg
Flash Point: 192.9℃
Molar Volume: 207.7cm3
Density: 1.79g/cm3
Index of Refraction: 1.645
Molar Refractivity: 75.37cm3
Surface Tension: 54.7dyne/cm
Polarizability: 29.88 10-24cm3
Enthalpy of Vaporization: 61.7kJ/mol
Vapour Pressure: 5.23E-06mmHg at 25℃
Uses
Heptachlor (76-44-8) can be used as a insecticide.
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| cat | LCLo | inhalation | 150mg/m3/4H (150mg/m3) | "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 71, 1982. | |
| cat | LDLo | oral | 50mg/kg (50mg/kg) | BEHAVIORAL: EXCITEMENT BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) BEHAVIORAL: AGGRESSION | Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 2(5), Pg. 15, 1958. |
| guinea pig | LD50 | oral | 116mg/kg (116mg/kg) | Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. Vol. -, Pg. 576, 1966. | |
| guinea pig | LDLo | skin | 1gm/kg (1000mg/kg) | BEHAVIORAL: EXCITEMENT BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) BEHAVIORAL: AGGRESSION | Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 2(5), Pg. 15, 1958. |
| hamster | LD50 | oral | 100mg/kg (100mg/kg) | European Journal of Toxicology and Environmental Hygiene. Vol. 7, Pg. 159, 1974. | |
| mammal (species unspecified) | LCLo | inhalation | 200mg/m3/4H (200mg/m3) | BEHAVIORAL: EXCITEMENT BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) BEHAVIORAL: AGGRESSION | Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 2(5), Pg. 15, 1958. |
| mammal (species unspecified) | LD50 | unreported | 60mg/kg (60mg/kg) | "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971Vol. -, Pg. 59, 1971. | |
| mouse | LD50 | intracrebral | 12mg/kg (12mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Toxicology Letters. Vol. 60, Pg. 289, 1992. |
| mouse | LD50 | intraperitoneal | 130mg/kg (130mg/kg) | Soviet Genetics. English translation of GNKAA5. Vol. 2, Pg. 80, 1966. | |
| mouse | LD50 | oral | 68mg/kg (68mg/kg) | Special Publication of the Entomological Society of America. Vol. 78-1, Pg. 12, 1978. | |
| mouse | LDLo | intravenous | 20mg/kg (20mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 107, Pg. 266, 1953. | |
| rabbit | LD50 | skin | 500mg/kg (500mg/kg) | Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 2(5), Pg. 15, 1958. | |
| rat | LD50 | intraperitoneal | 27mg/kg (27mg/kg) | BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) | Food and Cosmetics Toxicology. Vol. 11, Pg. 63, 1973. |
| rat | LD50 | oral | 40mg/kg (40mg/kg) | Pharmaceutical Journal. Vol. 185, Pg. 361, 1960. | |
| rat | LD50 | skin | 119mg/kg (119mg/kg) | Special Publication of the Entomological Society of America. Vol. 78-1, Pg. 12, 1978. |
Consensus Reports
IARC Cancer Review: Group 3 IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man.7,1987,p.146.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man.20,1979,p.129.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210);Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man.5,1974,p.173.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A.,49 Sheridan Avenue, Albany, NY 12210) ; Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 20 , 1979,p. 129.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . NCI Carcinogenesis Bioassay (feed) Clear Evidence: mouse NCITR*National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD 20014) No. NCI-CG-TR-9 ,1977. ; Results negative: rat NCITR*National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD 20014) No. NCI-CG-TR-9 ,1977. . EPA Genetic Toxicology Program. Community Right-To-Know List.
Safety Profile
Hazard Codes: 
T Toxic, 
N Dangerous for the environment, 
F Flammable, 
Xn Harmful.
Risk Statements: 24/25-33-40-50/53-39/23/24/25-23/24/25-11-67-65-38
R24/25: Toxic in contact with skin and if swallowed.
R33: Danger of cumulative effects.
R40: Limited evidence of a carcinogenic effect.
R50/53: Very Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
R39/23/24/25: Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed.
R23/24/25: Toxic by inhalation, in contact with skin and if swallowed.
R11: Highly Flammable.
R67: Vapors may cause drowsiness and dizziness.
R65: Harmful: May cause lung damage if swallowed.
R38: Irritating to the skin.
Safety Statements: 36/37-45-60-61-62-16-7
S36/37: Wear suitable protective clothing and gloves.
S45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible).
S60: This material and/or its container must be disposed of as hazardous waste.
S61: Avoid release to the environment. Refer to special instructions safety data sheet.
S62: If swallowed, do not induce vomiting: seek medical advice immediately and show this container or label.
S16: Keep away from sources of ignition-No smoking.
S7: Keep container tightly closed.
RIDADR: 2761
RTECS: PC0700000
HazardClass: 6.1(a)
PackingGroup: II
Confirmed carcinogen with experimental carcinogenic data. A poison by ingestion, skin contact, intraperitoneal, and intravenous routes. Human mutation data reported. Acute exposure and chronic doses have caused liver damage. See also closely related chlordane. In humans, a dose of 1-3 g can cause serious symptoms, especially where liver impairment is the case. Acute symptoms include tremors, convulsions, kidney damage, respiratory collapse, and death.
Standards and Recommendations
OSHA PEL: TWA 0.5 mg/m3 (skin)
ACGIH TLV: 0.05 mg/m3 (skin); Animal Carcinogen
DFG MAK: 0.5 mg/m3, Confirmed Animal Carcinogen with Unknown Relevance to Humans.
Specification
Heptachlor (76-44-8) also called for Velsicol 104(r) ; E3314 ; E3314(r) ; Drinox(r) ; Cupincida ; Fennotox;(-)-heptachlor ; (+)-Heptachlor . Heptachlor (76-44-8) is a white to light tan waxy looking solid.It's noncombustible and insoluble in waterWhen heated to decomposition it emits toxic fumes of Cl−.It should be stored at 4℃.Be attention of this chemical is highly toxic.